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2,031 results for “transformation”
VEGA2 TV SYSTEM IMAGES TRANSFORMED BY IKF V1.0
The TVS data from Institute Kosmosforschung (IKF) is in various stages. The submission is a single image which was smoothed or transformed by image processing techniques.
Improving Computational Efficiency of Prediction in Model-based Prognostics Using the Unscented Transform
Model-based prognostics captures system knowledge in the form of physics-based models of components, and how they fail, in order to obtain accurate predictions of end of life (EOL). EOL is predicted based on the esti- mated current state distribution of a component and ex- pected profiles of future usage. In general, this requires simulations of the component using the underlying mod- els. In this paper, we develop a simulation-based pre- diction methodology that achieves computational effi- ciency by performing only the minimal number of sim- ulations needed in order to accurately approximate the mean and variance of the complete EOL distribution. This is performed through the use of the unscented trans- form, which predicts the means and covariances of a distribution passed through a nonlinear transformation. In this case, the EOL simulation acts as that nonlinear transformation. In this paper, we review the unscented transform, and describe how this concept is applied to efficient EOL prediction. As a case study, we develop a physics-based model of a solenoid valve, and perform simulation experiments to demonstrate improved com- putational efficiency without sacrificing prediction accu- racy.
Transcription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic progression. Ionizing radiation (IR), both a carcinogen and a therapeutic agent, induces TGFbeta activation in vivo. We now show that IR sensitizes human mammary epithelial cells (HMEC) to undergo TGFbeta-mediated epithelial to mesenchymal transition (EMT). Non-malignant HMEC (MCF10A, HMT3522 S1 and 184v) were irradiated with 2 Gy shortly after attachment in monolayer culture, or treated with a low concentration of TGFbeta (0.4 ng/ml), or double-treated. All double-treated (IR+TGFbeta) HMEC underwent a morphological shift from cuboidal to spindle-shaped. This phenotype was accompanied by decreased expression of epithelial markers E-cadherin, beta-catenin and ZO-1, remodeling of the actin cytoskeleton, and increased expression of mesenchymal markers N-cadherin, fibronectin and vimentin. Furthermore, double-treatment increased cell motility, promoted invasion and disrupted acinar morphogenesis of cells subsequently plated in Matrigel. Neither radiation nor TGFbeta alone elicited EMT, even though IR increased chronic TGFbeta signaling and activity. Gene expression profiling revealed that double treated cells exhibit a specific 10-gene signature associated with Erk/MAPK signaling. We hypothesized that IR-induced MAPK activation primes non-malignant HMEC to undergo TGFbeta-mediated EMT. Consistent with this, Erk phosphorylation were transiently induced by irradiation, persisted in irradiated cells treated with TGFbeta, and treatment with U0126, a Mek inhibitor, blocked the EMT phenotype. Together, these data demonstrate that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression. Experiment Overall Design: Nonmalignant human mammary epithelial MCF10A cells (passages 106 and 108) were seeded at cloning density in 35mm dishes (10^5 cells/dish). Cell culture medium consisted of 3ml/dish of MGEM serum free medium (Cambrex Inc.), supplemented or not with 400pg/ml recombinant Transforming Growth Factor-beta. Cells were irradiated or not 5h post plating using 160 KV X-ray with a total dose of 2Gy. Sham, IR-treated, TGFbeta-treated and double-treated (IR+TGFbeta) MCF10A cells were harvested 8 days post-IR. Briefly, cells were washed with PBS, denatured in Trizol, scraped off the dish and subjected to chloroform extraction. After centrifugation, the upper phase was precipitated with an equal volume of isopropanol. RNA precipitates were resuspended in RNase free water and further purified on RNeasy columns (Qiagen, Germany). RNA quality was assessed on an Agilent Bio-Analyzer. The dataset analyzed by microarray included biological duplicates for each treatment in two independent experiments and three sham treated samples. Microarray data were generated at the Lawrence Berkeley National Laboratory Molecular Profiling Laboratory (http://hta.lbl.gov) using a high-throughput, automated GeneChip system (Affymetrix). Briefly, target preparation, HT_HG-U133A array plate hybridization setup, washing and staining were performed on an Affymetrix robotic system (GCAS) using version 2.1 protocols. Scanning (protocol version 2.2.09) was performed on a CCD-based high throughput scanner (Affymetrix). Samples were analyzed and clustered with the (UNO) One Color GenetrafficTM software version 3.2-12 (Iobion Informatics LLC, Stratagene, La Jolla, CA). Genes whose expression was specifically altered by treatment were defined as those in which dye ratio was more than 1.75-fold (mean log2ratio>0.8) from baseline in at least three out of the four treated samples compared to the three sham samples. Significance analysis tests (p<0.05) were performed using Excel between sham samples and either IR, TGFbeta or TGFbeta+IR samples.
Investigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells
GEO Series GSE24097. Homo sapiens. 8 samples. Type: Expression profiling by array.
Loss of BTG1 function promotes ETV6-RUNX1-mediated leukemic transformation by upregulation of BCL6
GEO Series GSE60589. Mus musculus. 4 samples. Type: Expression profiling by array.
5-aza-2'-cytidine and trichostatin A effect to gene expression of Epstein-Barr virus-transformed human lymphoblastoid cell lines (LCLs).
GEO Series GSE35359. Homo sapiens. 4 samples. Type: Expression profiling by array.
LncRNA-ENST00000501520 promotes the proliferation of malignant-transformed BEAS-2B cells induced with coal tar pitch mediated by target genes
GEO Series GSE134069. Homo sapiens. 9 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Gene expression profiling of clear cell renal cell carcinoma with sarcomatoid transformation
GEO Series GSE285848. Homo sapiens. 12 samples. Type: Other.
Blocking oncogenic Ras-induced β-catenin degradation and prosenescent inflammation redirects premature senescence to mesenchymal transformation (miRNA expression)
GEO Series GSE132096. Homo sapiens; Mus musculus. 2 samples. Type: Non-coding RNA profiling by array.
Digital transformation of herbal medicine: Conversion to biological entity data using tonifying herbal medicine-induced transcriptome sequencing_SW1783_batchF
GEO Series GSE245911. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing.
MiRNA array based, miRNA expression profiles of oral leukoplakia (OLK) and malignant transformed oral leukoplakia (mtOLK)
GEO Series GSE33299. Homo sapiens. 30 samples. Type: Non-coding RNA profiling by array.
Epigenetic enhancer changes during oncogenic transformation [ChIP-seq]
GEO Series GSE101170. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis [RNA-Seq]
GEO Series GSE311314. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide pairwise analysis of normal and spontaneously transformed adipose tissue derived human multipotent stromal cells (hMSC)
GEO Series GSE42809. Homo sapiens. 12 samples. Type: Expression profiling by array.
Overexpression of IGF-1 During Early Development Expands the Number of Mammary Stem Cells and Primes them for Transformation
GEO Series GSE173988. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The MLL3/GRHL2 complex regulates early malignant transformation and anti-tumor immunity in squamous cancer
GEO Series GSE238119. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide characterization of the transcriptional program of Myc-dependent transformation, expression study
GEO Series GSE14263. Homo sapiens. 16 samples. Type: Expression profiling by array.
Prevention of chromatin destabilization by FACT is crucial for malignant transformation
GEO Series GSE132576. Mus musculus. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CDDO drives transcriptomic and epigenetic reprogramming in response to TPA-induced JB6 cell neoplastic transformation [RNA-seq]
GEO Series GSE206167. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic enhancer changes during oncogenic transformation [RNA-seq]
GEO Series GSE101241. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.