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Dataset results
189 results for “Aplastic Anemia”
Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic Anemia
ClinicalTrials.gov study NCT06613880. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndr
ClinicalTrials.gov study NCT02462252. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Study of Non Severe Aplastic Anemia Treated With Cyclosporine, Androgen and Levamisole
ClinicalTrials.gov study NCT03218657. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Efficacy and Safety of Thrombopoietin In Patients With Severe and Very Severe Aplastic Anemia
ClinicalTrials.gov study NCT02857530. IPD Sharing: NO. Countries: 1. Publications: 0.
Drug Etiology of Aplastic Anemia and Related Dyscrasias
ClinicalTrials.gov study NCT00005302. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy
ClinicalTrials.gov study NCT04436367. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Purified CD34+ Hematopoietic Stem Cell Transplantation From Alternate Donors for Patients With Severe Aplastic Anemia
ClinicalTrials.gov study NCT00186797. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Transfusion-dependent Nonsevere Aplastic Anemia With Luspatercept: a Multicenter Prospective Clinical Study
ClinicalTrials.gov study NCT06964971. IPD Sharing: NO. Countries: 1. Publications: 0.
Transcriptome analysis of HSPCs and T cells from aplastic anemia (AA) and healthy donors
GEO Series GSE145669. Homo sapiens. 9148 samples. Type: Expression profiling by high throughput sequencing.
CD3+ T cells derived from bone marrow or peripheral blood of aplastic anemia patients
GEO Series GSE3807. Homo sapiens. 8 samples. Type: Expression profiling by array.
Significantly decreased hypoxanthine levels in bone marrow plasma of aplastic anemia patients revealed by 800 MHz NMR based metabolomics analysis
<p><strong>Background:</strong> Compared to plasma, the hypoxanthine (HX) concentration is three times higher in the human bone marrow <strong>[R1]</strong> and its availability is crucial to regulate the de novo purine synthesis in human bone marrow <em>in vivo</em> <strong>[R1]</strong>. Studies have shown that circulatory HX levels in the plasma increase in patients with solid tumors and leukemia <strong>[R2]</strong>. Aplastic anemia (AA) is rare disorder of bone marrow failure characterized by hypocellularity and peripheral cytopenias. As purine biosynthesis is essential for normal cell growth and proliferation, we hypothesized that bone marrow HX levels will be decreased in aplastic anemia (AA) patients and may reset back partially in AA patients showing clinical improvement. </p> <p><strong>Aim:</strong> To compare the HX levels in bone marrow plasma samples of AA patients and control subjects and further to check its metabolic reprogramming in AA patients showing clinical improvement. </p> <p><strong>Methods:</strong> The HX levels of bone marrow plasma metabolites were estimated for 56 AA patients and 20 control subjects using 800 MHz NMR spectroscopy. The NMR spectra were analyzed using NMR suite of commercial software (CHENOMX). The levels of altered metabolites in AA patients w.r.t control were estimated and the values are reported as Mean ± SD (SD is standard deviation). The diagnostic potential is evaluated employing standard receiver operating characteristic (ROC) curve analysis.</p> <p><strong>Results:</strong> The present study aims to compare the bone marrow plasma metabolic profiles of hypoxanthine between age and sex matched AA patients (N=40; mean age 32.31±16.03, male/female ratio of 22/18) and follow-up AA patients (N=16) with respect to age matched control subjects (N=20, mean age=39.5±18.48 years, male/female ratio of 11/9). The comparison revealed that the HX levels are significantly decreased in AA patients (HX=3.62 ± 3.17) compared to NC subjects (HX = 20.89 ± 12.73) and improved slightly in follow-up patients (HX=6.21 ±4.77, however no statistically significant change compared to AA patients). Further, the circulatory HX levels exhibit significant diagnostic potential with area under ROC (AUROC) curve values equal to 0.96 [95%CI = 0.92–1.00].</p> <p><strong>Concluding remarks:</strong> The depleted HX levels in the bone marrow plasma suggested altered/compromised purine biosynthesis/metabolism in AA patients and future studies are warranted to underscore its role in the disease pathobiology.</p> <p> </p> <p><strong>Reference:</strong></p> <p>[R1] King, M.E., Honeysett, J.M. and Howell, S.B., 1983. Regulation of de novo purine synthesis in human bone marrow mononuclear cells by hypoxanthine. <em>The Journal of clinical investigation</em>, <em>72</em>(3), pp.965-970.</p> <p>[R2] Wung WE, Howell SB. Hypoxanthine concentrations in normal subjects and patients with solid tumors and leukemia. Cancer research. 1984 Jul;44(7):3144-8.</p>
Safety and Efficacy of the JAK1 Inhibitor Combined With Intensive Immunosuppressive Therapy in Severe Aplastic Anemia
ClinicalTrials.gov study NCT07297550. IPD Sharing: NO. Countries: 0. Publications: 0.
Expanded Access Use of Itacitinib to Treat a Single Patient With Aplastic Anemia
ClinicalTrials.gov study NCT03906318. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Assesment of Treatment Outcomes of Aquired Aplastic Anemia in Children : A Retrospective and Prospective Cohort
ClinicalTrials.gov study NCT07131878. IPD Sharing: NO. Countries: 0. Publications: 0.
Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant
ClinicalTrials.gov study NCT00005852. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Reduced-dose Conditioning Regimen Containing TBI in HSCT Treating Elderly Patients With Aplastic Anemia
ClinicalTrials.gov study NCT06769568. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Up-front Matched Unrelated Donor Transplantation in Pediatric Patients With Idiopathic Aplastic Anemia
ClinicalTrials.gov study NCT05419843. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Reduced-Intensity Preparative Regimen for Allogeneic Stem Cell Transplantation in Patients With Severe Aplastic Anemia
ClinicalTrials.gov study NCT01129323. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia
ClinicalTrials.gov study NCT03208647. IPD Sharing: NO. Countries: 0. Publications: 0.
Clinico-Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate .
ClinicalTrials.gov study NCT07259863. IPD Sharing: NO. Countries: 0. Publications: 0.
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