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2,302
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Dataset results
2,302 results for “B-cells”
Antigen-Independent, Autonomous B-cell Receptor Signalling in Diffuse Large B-cell Lymphoma
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Healthy and B-cell precursor Acute Lymphoblastic Leukemia (ALL) cells analyzed via CyTOF
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Profiling of linear B-cell epitopes against human coronaviruses in pooled sera sampled early in the COVID-19 pandemic
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Data from: A public database of memory and naive B-cell receptor sequences
The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics.
Simulated B-cells Rep-Seq datasets (called SIMULATED) from "Reconstructing antibody repertoires from error-prone immunosequencing datasets" paper
<p>Simulated test datasets used for benchmarking of immunorepertoire construction tools</p>
Peripheral blood DNA methylation profiles predict future development of B-cell Non-Hodgkin Lymphoma
<p>Lack of accurate methods for early lymphoma detection limits the ability to cure patients. Patients with Non-Hodgkin lymphomas (NHL) who present with advanced disease have worse outcomes.</p> <p>We developed a DNA methylation-based prediction tool for NHL, based on blood samples collected prospectively from 278 apparently healthy patients who were followed for up to 16 years to monitor for NHL development. A predictive score was developed using machine learning methods in a robust training/validation framework.</p> <p>Our predictive score incorporates CpG DNA methylation at 135 genomic positions, with higher scores predicting higher risk. It was 85% and 78% accurate for identifying patients at risk of developing future NHL, in patients with high or low epigenetic mitotic clock respectively, in a validation cohort. It was also sensitive at detecting active NHL (96.3% accuracy) and healthy status (95.6% accuracy) in additional independent cohorts. Scores optimized for specific NHL subtypes showed significant but lower accuracy for predicting other subtypes. Our score incorporates hyper-methylation of Polycomb and <em>HOX</em> genes, which have roles in NHL development, as well as <em>PAX5</em> - a master transcriptional regulator of B-cell fate. Subjects with higher risk scores showed higher regulatory T-cells, memory B-cells, but lower naïve T helper lymphocytes fractions in the blood.</p> <p>A score based on DNA methylation in blood is accurate at predicting NHL development with lead time of up to 16 years. Future prospective studies will be required to confirm the utility of our signature for managing patients who are at high risk for developing future NHL.</p>
NanoString dataset for study: Dynamic changes in the NK-, Neutrophil-, and B-cell immunophenotypes relevant in high metastatic risk post neoadjuvant chemotherapy–resistant early breast cancers
<p>Pre-processed DSP and mRNA abundance datasets used in this study.</p>
Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
ClinicalTrials.gov study NCT02436707. IPD Sharing: YES. Countries: 1. Publications: 1.
Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refrac
ClinicalTrials.gov study NCT06986382. IPD Sharing: NO. Countries: 1. Publications: 13.
Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leu
ClinicalTrials.gov study NCT06287229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Tisagenlecleucel in Combination With Ibrutinib in r/r Diffuse Large B-cell Lymphoma Patients
ClinicalTrials.gov study NCT03876028. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT03991884. IPD Sharing: NO. Countries: 1. Publications: 1.
Low Dose Radiotherapy in Primary Indolent Cutaneous B-cell Lymphoma
ClinicalTrials.gov study NCT07310745. IPD Sharing: Not stated. Countries: 1. Publications: 6.
CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies
ClinicalTrials.gov study NCT04450069. IPD Sharing: NO. Countries: 1. Publications: 3.
A Safety Study of SGN-CD19B in Patients With B-cell Non-Hodgkin Lymphoma
ClinicalTrials.gov study NCT02702141. IPD Sharing: Not stated. Countries: 1. Publications: 1.
DA-EDOCH14-R in Poor-prognosis Diffuse Large B-cell Lymphoma
ClinicalTrials.gov study NCT01066429. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Omic Technologies Applied to the Study of B-cell Lymphoma for the Discovery of Diagnostic and Prognosis Biomarkers
ClinicalTrials.gov study NCT05834426. IPD Sharing: NO. Countries: 1. Publications: 7.
Immunotoxin Therapy and Cytarabine in Treating Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT01408160. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
ClinicalTrials.gov study NCT04830137. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Study in Young Adults to Examine the Kinetics of Changes in the B-cell Repertoire Following TIV Immunization
ClinicalTrials.gov study NCT02987374. IPD Sharing: YES. Countries: 0. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.