Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
606
datasets available to search
ShareScore release 0.7.1
Dataset results
606 results for “Bioactivation”
Bioactive Glass Granules in Filling of Bone Defects
ClinicalTrials.gov study NCT01304121. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Myrosinase Bioactivated Gglucoraphanin for the Treatment of Neurodegenerative Diseases (GRA-MYR-ND)
ClinicalTrials.gov study NCT07360977. IPD Sharing: NO. Countries: 1. Publications: 8.
Effects of Pulses Through the Gut Microbiome and Bioavailability of Bioactive Compounds
ClinicalTrials.gov study NCT05999136. IPD Sharing: YES. Countries: 1. Publications: 2.
Bioactive Composite Versus Resin-Modified Glass Ionomer Liners: 2-Year Clinical Trial
ClinicalTrials.gov study NCT05470959. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Long read reference genome-free reconstruction of a full-length transcriptome from Astragalus membranaceus reveals transcript variants involved in bioactive compound biosynthesis
Open the record for dataset details and reuse information.
Data from: Evolutionary origins of a bioactive peptide buried within preproalbumin
The de novo evolution of proteins is now considered a frequented route for biological innovation, but the genetic and biochemical processes that lead to each newly created protein are often poorly documented. The common sunflower (Helianthus annuus) contains the unusual gene PawS1 (Preproalbumin with SFTI-1) that encodes a precursor for seed storage albumin; however, in a region usually discarded during albumin maturation, its sequence is matured into SFTI-1, a protease-inhibiting cyclic peptide with a motif homologous to unrelated inhibitors from legumes, cereals, and frogs. To understand how PawS1 acquired this additional peptide with novel biochemical functionality, we cloned PawS1 genes and showed that this dual destiny is over 18 million years old. This new family of mostly backbone-cyclic peptides is structurally diverse, but the protease-inhibitory motif was restricted to peptides from sunflower and close relatives from its subtribe. We describe a widely distributed, potential evolutionary intermediate PawS-Like1 (PawL1), which is matured into storage albumin, but makes no stable peptide despite possessing residues essential for processing and cyclization from within PawS1. Using sequences we cloned, we retrodict the likely stepwise creation of PawS1's additional destiny within a simple albumin precursor. We propose that relaxed selection enabled SFTI-1 to evolve its inhibitor function by converging upon a successful sequence and structure.
Data from: Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction
A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting materials as 5-bromothiophene-2-carboxaldehyde and ammonium acetate were used at room temperature under solvent-free condition for the Hantzsch pyridine synthesis within a short period of time. All compounds were evaluated for their in vitro antibacterial and antifungal activity and, interestingly, we found that 5(b–f) show excellent activity compared with Ampicillin, whereas only the 5e compound shows excellent antifungal activity against Candida albicans compared with griseofulvin. The cytotoxicity of all compounds has been assessed against breast tumour cell lines (BT-549), but no activity was found. The X-ray structure of one such compound, 5a, viewed as a colourless block crystal, corresponded accurately to a primitive monoclinic cell.
Data from: Random sequences are an abundant source of bioactive RNAs or peptides
It is generally assumed that new genes arise through duplication and/or recombination of existing genes. The probability that a new functional gene could arise out of random non-coding DNA is so far considered to be negligible, as it seems unlikely that such an RNA or protein sequence could have an initial function that influences the fitness of an organism. Here, we have tested this question systematically, by expressing clones with random sequences in Escherichia coli and subjecting them to competitive growth. Contrary to expectations, we find that random sequences with bioactivity are not rare. In our experiments we find that up to 25% of the evaluated clones enhance the growth rate of their cells and up to 52% inhibit growth. Testing of individual clones in competition assays confirms their activity and provides an indication that their activity could be exerted by either the transcribed RNA or the translated peptide. This suggests that transcribed and translated random parts of the genome could indeed have a high potential to become functional. The results also suggest that random sequences may become an effective new source of molecules for studying cellular functions, as well as for pharmacological activity screening.
Data from: Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC–MS/MS: in vitro metabolic investigation
Abemaciclib (Verzenio®) is approved as tyrosine kinase inhibitor (TKI) for breast cancer treatment. In this study, in vitro phase I metabolic profiling of Abemaciclib (ABC) was done using rat liver microsomes (RLMs). We checked the formation of reactive intermediates in ABC metabolism using (RLMs) in the presence of potassium cyanide (KCN) that was used as capturing agent for iminium reactive intermediates forming a stable complex that can be characterized by LC-MS/MS. Nine in vitro phase I metabolites and three cyano adducts were identified. The metabolic reactions involved in formation of these metabolites and adducts are reduction, oxidation, hydroxylation and cyanide addition. The bioactivation pathway was also proposed. Knowing the electrodeficient bioactive centre in ABC structure helped in making targeted modifications to improve its safty and retain its efficacy. Blocking or isosteric replacement of α carbon to the tertiary nitrogen atoms of piperazine ring can aid in reducing toxic side effects of ABC. No previous articles were found about in vitro metabolic profiling for ABC or structural identification of the formed reactive metabolites for ABC.
Figure 1 from: Talib WH, Atawneh S, Shakhatreh AN, Shakhatreh GN, Rasheed aljarrah IS, Hamed RA, Adel banyyounes D, Al-Yasari IH (2024) Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds. Pharmacia 71: 1-23. https://doi.org/10.3897/pharmacia.71.e114556
Figure 1 Enhancement of DNA repair mechanisms by garlic compounds (created by BioRender.com). This diagram illustrates how garlic compounds enhance DNA repair mechanisms: DNA Damage: The process begins with DNA damage, represented as breaks and mutations in the DNA strands. Recognition: The damaged DNA is recognized by cellular repair machinery, signaling the need for repair. Garlic Compounds: Garlic compounds, highlighted in the diagram, play a crucial role at this stage. They are known for their Genoprotective properties. DNA Repair Mechanism: The diagram illustrates the sequential steps of DNA repair, including excision, polymerization, and ligation. Enhanced Repair: Garlic compounds facilitate and enhance the DNA repair process, as indicated by connecting lines and arrows.
Figure 2 from: Talib WH, Atawneh S, Shakhatreh AN, Shakhatreh GN, Rasheed aljarrah IS, Hamed RA, Adel banyyounes D, Al-Yasari IH (2024) Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds. Pharmacia 71: 1-23. https://doi.org/10.3897/pharmacia.71.e114556
Figure 2 Angiogenesis processes and garlic compound interference (created by: BioRender.com). Fig. 2 provides an overview of the intricate process of angiogenesis within the tumor microenvironment and demonstrates how garlic compounds interfere with this critical pathway. Tumor Microenvironment: On the left, the tumor microenvironment is depicted as the origin of angiogenesis.
A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds
<p>Please find newer versions of the dataset on the <a href="https://ftp.ebi.ac.uk/pub/databases/chembl/Drug_Target_dataset/" target="_blank" rel="noopener">ChEMBL FTP site.</a></p> <p> </p>
Fig. 3. Key ROESY correlations for compounds 1, 5 and 6 in Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities
Fig. 3. Key ROESY correlations for compounds 1, 5 and 6.
Fig. 2. 1H–1 H COSY and key HMBC correlations for compounds 1–7 in Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities
Fig. 2. 1H–1 H COSY and key HMBC correlations for compounds 1–7.
Fig. 1 in Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities
Fig. 1. The structures of compounds 1–36 from Valeriana officinalis.
Fig. 9 in Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
Fig. 9. Experimental ECD spectra of 5 and 6 in MeCN.
Fig. 7. Proposed biosynthetic relationships between compounds 7 and 1–3 in Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
Fig. 7. Proposed biosynthetic relationships between compounds 7 and 1–3.
Fig. 4 in Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
Fig. 4. ORTEP drawing of 1.
Fig. 5 in Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
Fig. 5. Experimental and calculated ECD spectra of 2 in MeCN.
Fig. 2. 1H–1H in Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
Fig. 2. 1H–1H COSY (for 2–4, and 6) and selected HMBC correlations (for 1–6).
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.