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Dataset results
168 results for “Complex systems”
Process interoperability between biodiversity modeling systems: Engineering of complex systems.
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Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis [ZNF787]
GEO Series GSE118315. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis [d7+d14]
GEO Series GSE118310. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Distinctive Biological Properties Between Mesenchymal Stem Cells Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems.
GEO Series GSE247989. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
A multiplicity of perspectives on complex urban water systems transformation - a systematic review (supplemental data)
<p>This supplemental data contains all records (publication and reference materials) used in the systematic review of the literature (publication pending):</p> <p>1) Full list of publication records on urban water literature using the social-ecological systems and socio-technical systems framework extracted from the Web of Science and Scopus database (raw list).</p> <p>2) Selected list of corpus and sub-corpus literature from the original list after applying the inclusion and exclusion criteria.</p> <p>3) Keywords mapping drawn from the reference list using the Vosviewer application.</p>
Assurance for Complex Systems
Presentation given by SRI NRA winners on Verification and Validation for Complex Systems.
Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis
<p><strong>Background: </strong>Consistently with their diagnostic and prognostic value, autoantibodies specific for systemic sclerosis (SSc) embedded in immune complexes (ICs) elicited a pro-inflammatory and pro-fibrotic cascade in healthy skin fibroblasts, engaging Toll-like Receptors (TLRs) via their nucleic acid components. The objective of this study was to investigate the pathogenicity of SSc-ICs in endothelial cells.</p> <p><strong>Methods: </strong>ICs were purified from sera of SSc patients bearing different autoantibody specificities (antibodies against DNA topoisomerase I, centromeric proteins, RNA polymerase and Th/To), patients with systemic lupus erythematosus (SLE), primary anti-phospholipid syndrome (PAPS) or healthy controls (NHS) using polyethylen glycol precipitation. Human umbilical vein endothelial cells (HUVECs) were incubated with ICs, positive and negative controls. mRNA levels of <em>endothelin-1 (et-1)</em>, <em>collagenIα1 (colI</em><em>a</em><em>1)</em>, <em>interferon (IFN)-α</em> and <em>IFN-β</em> were investigated by Real-Time PCR; <em>et-1</em> and <em>il-6</em> mRNA levels were assessed after pre-treatment with bafilomycin. ICAM-1 expression was evaluated by cell-ELISA; secretion of IL-6, IL-8 and transforming growth factor (TGF)-β1 in culture supernatants was measured by ELISA. The expression of Fcg receptors (CD64, CD32 and CD16) was assessed in endothelial cells at FACS analysis. Intracellular signalling pathways culminating with NFkB, p38MAPK, SAPK-JNK and Akt were assessed by Western Blotting. Healthy skin fibroblasts were stimulated with supernatants from HUVEC incubated with ICs, and TGF-b1 secretion, mRNA levels of <em>colIα1</em> and <em>matrix metalloproteinase (mmp)-1</em>, protein expression of a smooth muscle actin (a-SMA) and IL-6 were evaluated by Western Blotting<em>; et-1</em> mRNA levels were assessed in fibroblasts pre-treated with IL-6 and TGF-b inhibitors and stimulated with ATA-ICs.</p> <p><strong>Results: </strong>All SSc stimulated IL-6 secretion; ACA-ICs and anti-Th/To-ICs increased ICAM-1 expression; all SSc-ICs but anti-Th/To-ICs augmented IL-8 levels; all SSc-ICs but ACA and ARA-ICs up-regulated <em>et-1 </em>and all SSc-ICs but ARA-ICs affected TGF-b1 secretion. c<em>olI</em><em>a</em><em>1</em>, <em>IFN-</em><em>a</em> and <em>IFN-</em><em>b </em>mRNA levels were not affected by any SSc-IC. FcgRII (CD32) and FcgRIII (CD16) were not detectable on HUVECs, while FcgRI (CD64) was minimally expressed. A differential modulation of<em> tlr</em> expression was observed: <em>tlr2</em>, <em>tlr3</em> and <em>tlr4</em> were up-regulated by ATA-ICs and ACA-ICs, while anti-Th/To-ICs resulted in <em>tlr9</em> up-regulation. Pre-treatment with bafilomycin did not affect the up-regulation of <em>et-1</em> and <em>il-6</em> induced by ATA-ICs, ACA-ICs and anti-Th/To-ICs; a 23% reduction in both genes was reported for ARA-ICs. All SSc-ICs activated p38MAPK and AKT, all SSc-ICs but ARA-ICs yielded the activation of NFkB; ATA-ICs and ACA-ICs increased the activation rate of both subunits of SAPK-JNK. When healthy skin fibroblasts were stimulated with supernatants from HUVECs incubated with SSc-ICs, TGF-b1 secretion, <em>colI</em><em>a</em><em>1, </em>a-SMA and IL-6 expression levels were significantly modulated. Pre-treatment with IL-6 and TGF-b inhibitors prevented <em>et-1</em> up-regulation induced by ATA-ICs by 85% and 77% respectively.</p> <p><strong>Conclusions: </strong>These data provide the first demonstration of the pathogenicity of ICs from scleroderma patients with different autoantibodies on the endothelium. Endothelial activation induced by SSc-ICs ultimately led to a pro-fibrotic phenotype in healthy skin fibroblasts.</p>
Restricted Data of the Reproducibility Package for the paper "Higher-Order Patterns Reveal Causal Timescales of Complex Systems"
<p>Datasets which are not ours, so we do not want to publish them openly. We submitted them here as a backup.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.