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1,724 results for “ESCALATOR”
A Dose-escalating Clinical Trial With KH176
ClinicalTrials.gov study NCT02544217. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data for: Environmentally-driven escalation of host egg-rejection decimates success of an avian brood parasite
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Data from: Grazing effect on grasslands escalated by abnormal precipitations in Inner Mongolia
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Riding an escalator: upward range shift and patterns of genetic response to climate change in Acer caudatifolium
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Native plant species are more resistant than invasive aliens to escalating environmental change factors
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Cave lynx Osteometrical Datasets from L'Escale Palaeontological site (South-East France)
<p><strong>Background</strong><br> These datasets provide osteometrical measurements for dental and postcranial remains in cave lynx from the Middle Pleistocene site of L’Escale (South-East France). The cave lynx sample from L’Escale is probably one of the richest and most important population for the European (Middle) Pleistocene.</p> <p><br> L’Escale Cave, located about 30 km north to Aix-en-Provence, has been excavated during the 1960’s under the direction of Eugène and Marie-Françoise Bonifay. This site, dated to the first half of the Middle Pleistocene, yielded remarkable faunal associations, including abundant thar – <em>Hemitragus bonali</em> – remains as well as numerous and highly diverse carnivores such as the wolverine <em>Gulo schlosseri</em>, the « european » jaguar <em>Panthera gombaszoegensis</em>, the cave lynx <em>Lynx spelaeus</em> as well as the fossil striped hyena <em>Hyaena prisca</em> (Bonifay, 1971 ; Bonifay, 1974-75). L’Escale presents a unique palaeobiological record mixing phases of carnivore occupations (bears, striped hyenas?, jaguars?, wolves?, foxes) and natural trapping events (thar) (Coumont, 2006).</p> <p> </p> <p><strong>Method</strong><br> All the specimens have been described and measured (in millimeters with callipers to 0.1mm) by the authors. They are stored and curated in the MNP – Musée National de Préhistoire, Les Eyzies, Dordogne, France.</p> <p><br> <strong>Data description</strong><br> <em>File title:</em><br> Each file is named according to the following pattern:<br> • <strong>First part</strong>: abreviation of considered species (i.e., Lps = Lynx pardinus spelaeus); <br> • <strong>Second part</strong>: anatomical part codification: <br> <em> ◦ MAND: Mandible <br> ◦ U: Upper / L: Lower<br> ◦ C: Canine / P: Premolar / M: Molar <br> ◦ 1 to 5: tooth or metapodials (metacarpals/metatarsals/phalanges) rank <br> ◦ HUM: Humerus / RAD: Radius / ULN: Ulna<br> ◦ FEM: Femur / TIB: Tibia<br> ◦ SCAPHL: Scapholunar (Carpal)<br> ◦ CALCA: Calcaneus (Tarsal)<br> ◦ TAL: Talus (Tarsal)<br> ◦ MTC: Metacarpals / MTT: Metatarsals</em></p> <p><em>File content</em>:<br> • <strong>chrono</strong>: Chronology (i.e., Middle or Late Pleistocene); <br> • <strong>MIS</strong>: Marine Isotopic Stage (if applicable); <br> • <strong>species</strong>: specific (or sub-specific) identification (i.e., Lynx spelaea); <br> • <strong>country</strong>: Site location (i.e., France); <br> • <strong>site</strong>: Site name; <br> • <strong>label</strong>: Specimen label such as archaeological number or museum inventory number; <br> • <strong>side</strong>: Specimen laterality, it could be left (sin) or right (dext); <br> •<strong> L_cond_infra (in mm)</strong>: length from the condyle process to infradental (in mm), applicable only for the mandible;<br> • <strong>L_angul_infra</strong>: length from the angular process to infradental (in mm), applicable only for the mandible;<br> • <strong>L_coron_infra</strong>: length from coronion to infradental (in mm), applicable only for the mandible;<br> • <strong>L_diast</strong>: Diastema length (in mm), applicable only for the mandible;<br> • <strong>L_rawtth</strong>: Raw teeth length (in mm);<br> • <strong>H_p3</strong>: Horizontal ramus height before p3 (in mm), applicable only for the mandible;<br> • <strong>H_m1</strong>: Horizontal ramus height behind m1 (in mm), applicable only for the mandible;<br> • <strong>B_c</strong>: Horizontal ramus breadth at lower canine (in mm), applicable only for the mandible;<br> •<strong> B_p3</strong>: Horizontal ramus breadth before p3 (in mm), applicable only for the mandible;<br> • <strong>B_m1</strong>: Horizontal ramus breadth behind m1 (in mm), applicable only for the mandible;<br> • <strong>B</strong>: Breadth (in mm); <br> • <strong>L</strong>: Breadth (in mm); <br> • <strong>GL</strong>: Greatest length (in mm);<br> • <strong>Dp</strong>: Depth of the proximal end (in mm), applicable only for long bones and metapodials;<br> • <strong>Bp</strong>: Greatest breadth of the proximal end (in mm), applicable only for long bones and metapodials;<br> • <strong>Ds</strong>: Depth of the diaphysis (in mm), applicable only for long bones and metapodials;<br> • <strong>SD</strong>: Smallest breadth of the diaphysis (in mm), applicable only for long bones and metapodials;<br> • <strong>Dd</strong>: Depth of the distal end (in mm), applicable only for long bones and metapodials;<br> • <strong>Bd</strong>: Greatest breadth of the distal end (in mm), applicable only for long bones and metapodials;<br> • <strong>B_troch</strong>: Breadth of the trochlea (in mm), applicable only for the humerus;<br> • <strong>DPA</strong>: Depth across the processus anconaeus (in mm), applicable only for the ulna;<br> • <strong>SDO</strong>: Smallet depth of the olceranon (in mm), applicable only for the ulna;<br> • <strong>BPC</strong>: Greatest breadth across the coronoid process (in mm), applicable only for the ulna;<br> • <strong>GB</strong>: Greatest breadth (in mm), applicable only for carpals/tarsals; <br> • <strong>H</strong>: Greatest height (in mm), applicable only for carpals/tarsals; <br> • <strong>GD</strong>: Greatest depth (in mm), applicable only for carpals/tarsals; <br> • <strong>location</strong>: Curation place. <br> <br> <strong>References</strong><br> • Bonifay, M.-F., 1974-1975. "Hemitragus bonali" Harlé et Stehlin, "Caprinae" de la grotte de l’Escale (Saint-Estève-Janson, Bouhes-du-Rhône). Quaternaria XVIII, 215–301.<br> • Bonifay, M.-F., 1971. Carnivores quaternaires du Sud-Est de la France. Mémoires du Muséum national d’Histoire naturelle, Sér. C – Sciences de la Terre 21, 1–334.<br> • Coumont, M.-P., 2006. Taphonomie préhistorique : mammifères fossiles en contexte naturel, les avens-pièges, apport pour l’étude des archéofaunes. Thèse de Doctorat. Université Aix-Marseille 1, Aix-en-Provence.</p>
Data from: Testing for escalation in Lower Mississippian camerate crinoids
Crinoids were relatively unaffected by the end-Devonian Hangenberg mass extinction event. Major clades of Devonian durophagous fishes suffered significant extinctions, however, and the dominant surviving clades were biting or nipping predators. In part as a response to the Hangenberg event, early Mississippian crinoids underwent an adaptive radiation, while fish clades with a shell-crushing durophagous strategy diversified. Durophagous predators are inferred to have been more effective predators on camerate crinoids; and it is hypothesized, following the predictions of escalation, that through the early Mississippian, camerate crinoids evolved more effective anti-predatory strategies in response. We test this hypothesis of escalation by examining the changes in spinosity and plate convexity among camerate crinoids throughout this interval. A new method was formulated to test for an increase in convexity of the tegmen plates. Traits in Agaricocrinus, Aorocrinus, and Dorycrinus (Family Coelocrinidae) were tested for congruence to the escalation hypothesis, and results were mixed. Convexity of tegmen plates in Agaricocrinus, spine length/calyx diameter in Aorocrinus, calyx size in Aorocrinus, central spine length in Dorycrinus, and spine width in Dorycrinus did not have size increase trends supporting escalation. Rather than an increase in convexity, the variance of convexity in Agaricocrinus tegmen plates narrowed, which could reflect an optimum. Alternatively, morphological change consistent with the escalation hypothesis occurred in calyx size of Agaricocrinus and in lateral spine length and calyx size in Dorycrinus. Furthermore, central and lateral spine length, parameters of the spine width, and size trends support escalation when Aorocrinus and Dorycrinus are treated as a lineage. Thus, inferred escalation acted on traits differently within a single lineage and was relevant for both speciation and the diversification of a new genus.
Single-center, double-blind, randomized, placebo-controlled, single andmultiple dose escalation study to assess safety and tolerability and pharmacokinetics of HRX215 in healthy male volunteers under food and fasting conditions
<p><a name="_Hlk123284665"></a><a name="_Hlk135557103"></a><span><span>Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. </span></span><span><span>Therapies to restore hepatocyte regeneration are lacking, making liver transplantation the only curative option for end stage liver disease. We here report on the structure-based development and characterization (NMR-spectroscopy) of first-in-class small molecule inhibitors of the dual specific kinase MKK4 (MKK4i). MKK4i increased liver regeneration upon hepatectomy in murine and porcine models, allowed for survival of pigs in a lethal 85% hepatectomy model and showed antisteatotic and antifibrotic effects in liver disease mouse models. A first-in-human phase I trial (EudraCT 2021-000193-28) with the clinical candidate HRX215 was conducted and revealed excellent safety and pharmacokinetics. Clinical trials to probe HRX215 for prevention/treatment of liver failure after extensive oncological liver resections or after transplantation of small grafts are warranted.</span></span></p>
Data for: Escalating conflicts between brick kilns and nearby human-nature synergy in the Asian Brick Belt
<p>Data and code of "Escalating conflicts between brick kilns and nearby human-nature synergy in the Asian Brick Belt". We provide the developed data of brick kilns from 1991 to 2022 within the Asian Brick Kiln Belt, along with some of the validation datasets generated. Additionally, we also provide the core code of our research.</p>
Data from: Extreme escalation of heat failure rates in ectotherms with global warming
<p>Data from: Extreme escalation of heat failure rates in ectotherms with global warming</p>
Essential Features of Escalated Force and Negotiated Management Models
<p><strong><span>Skrzypek, Maciej, Essential Features of Escalated Force and Negotiated Management Models</span></strong></p> <p><strong><span>This dataset was elaborated for the research project <em>Civil Disorder in Pandemic-ridden European Union</em>. The latter was financially supported by the National Science Centre, Poland [grant number 2021/43/B/HS5/00290].</span></strong></p>
A Phase I Dose Escalation Study of CGM097 in Adult Patients With Selected Advanced Solid Tumors
ClinicalTrials.gov study NCT01760525. IPD Sharing: NO. Countries: 5. Publications: 1.
A First in Human, Dose Escalation Study to Evaluate the Safety and Tolerability of BBP-671 in Healthy Volunteers and Patients With Propionic Acidemia or Methylmalonic Acidemia
ClinicalTrials.gov study NCT04836494. IPD Sharing: NO. Countries: 1. Publications: 1.
Natalizumab De-escalation to Interferon-beta-1b in Patients With Relapsing-remitting Multiple Sclerosis
ClinicalTrials.gov study NCT01701856. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Ta
ClinicalTrials.gov study NCT02132299. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Phase I - Escalating Dose Study of siG12D LODER (Local Drug EluteR) in Patients With Locally Advanced Adenocarcinoma of the Pancreas, and a Single Dose Study of siG12D LODER (Local Drug EluteR) in Pat
ClinicalTrials.gov study NCT01188785. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer
ClinicalTrials.gov study NCT02635672. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Dose Escalation Study of I-131-CLR1404 in Patients With Relapsed or Refractory Multiple Myeloma
ClinicalTrials.gov study NCT02278315. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dose Escalation Trial of Dalotuzumab (MK-0646) in Advanced Solid Tumors and Multiple Myeloma (MK-0646-001)
ClinicalTrials.gov study NCT00701103. IPD Sharing: YES. Countries: 0. Publications: 1.
A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Advanced Solid Tumors and Metastatic Brain Cancer
ClinicalTrials.gov study NCT00539383. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.