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172
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ShareScore release 0.9.0
Dataset results
172 results for “Genome-wide association studies”
Integrative genomic analyses revealed colorectal cancer susceptibility genes in risk loci identified in genome-wide association studies
GEO Series GSE121553. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Integrating a genome-wide association study with a large-scale transcriptome analysis to predict genetic regions influencing the glycemic index and texture in rice
GEO Series GSE123616. Oryza sativa Indica Group. 21 samples. Type: Expression profiling by array.
Boxer dataset for genome-wide association study of modifiers of risk of canine degenerative myelopathy in dogs homozygous for SOD1 mutation
GEO Series GSE80315. Canis lupus familiaris. 25 samples. Type: SNP genotyping by SNP array.
Genome-wide association study and transcriptome analysis discover novel genes for bacterial leaf streak resistance in rice
GEO Series GSE229200. Oryza sativa. 12 samples. Type: Expression profiling by high throughput sequencing.
Neuroblastoma Genome-Wide Association Study
Neuroblastoma is a malignancy of the developing sympathetic nervous system that most commonly affects young children and is often lethal. The etiology of this embryonal cancer is not fully understood. We therefore initiated a genome-wide association study (GWAS) in 2007 focused on neuroblastoma patients identified through the Children's Oncology Group (COG; 238 member institutions). Control patients for this study are children cared for at the Children's Hospital of Philadelphia (CHOP) without a diagnosis or family history of cancer. The study was initially designed to genotype 5,000 neuroblastoma cases and 10,000 controls and is powered to detect common susceptibility variants in Caucasian and African American patients. Whole genome genotyping was performed on multiple versions of Illumina SNP arrays. This version of the study represents the complete set of cases genotyped.
Genome-Wide Association Study of Relapse of Childhood Acute Lymphoblastic Leukemia
Using risk-directed therapy for childhood acute lymphoblastic leukemia (ALL), outcome has improved dramatically in the last 40 years. However, a substantial portion of patients experience relapse, many of whom have no known risk factors. Taking a genome-wide approach, we sought to evaluate the relationships between germline SNP genotypes and the risk of relapse in 2,535 children with newly diagnosed ALL after adjusting for genetic ancestry and treatment regimen. We examine prognostic value of selected SNPs in the context of known relapse risk factors (molecular subtypes, minimal residual disease, age and leukocyte count at diagnosis). Associations of relapse-related SNPs with pharmacokinetic and pharmacodynamics of antileukemic drugs offer plausible mechanism by which they are linked to treatment outcome. Finally, we aim to identify SNPs that are related to both genetic ancestry and relapse which are likely to contribute to racial disparities in ALL survival.
A Genome-Wide Association Study (GWAS) of Risk for Osteosarcoma
This is a genome-wide association study (GWAS) of osteosarcoma, the most common primary bone malignancy. Osteosarcoma typically occurs in adolescents and young adults. It occurs at increased frequency in several inherited cancer predisposition syndromes but the genetic contribution to sporadic osteosarcoma is largely unexplored. The objective of this study was to identify genetic risk factors for osteosarcoma by conducting a genome-wide association study. We developed collaborations with multiple institutions in order to attain the necessary sample size required to discover novel loci in the genome associated with osteosarcoma using the GWAS approach. Genomic DNA (either blood or buccal in source) derived from osteosarcoma cases was obtained from each participating institution or research group. De-identified blood or buccal cell DNA samples from osteosarcoma cases were derived from existing biobanks at the collaborative institutions. Control subjects were derived from existing NCI cohorts and matched by gender and ethnicity.
Genome-wide study the fruit ripening associated lncRNAs in strawberry
GEO Series GSE129032. Fragaria vesca. 18 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide association study and transcriptome analysis provide new insights into the white/red earlobe color formation in chicken
GEO Series GSE110145. Gallus gallus. 200 samples. Type: Genome variation profiling by high throughput sequencing.
Genome-wide association study of RegX3 in M. tuberculosis (Mtb) grown under phosphate limited conditions
GEO Series GSE182669. Mycobacterium tuberculosis. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide association study on Tuberculosis in the Chinese Population
GEO Series GSE83397. Homo sapiens. 1008 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Ewing Sarcoma Genome-wide Association Study
Ewing sarcoma (EwS) is a pediatric bone and soft tissue tumor for which genetic risk factors remain poorly understood. DCEG investigators are studying inherited genetic variation to identify regions in the genome associated with increased risk of EwS. They accomplish this by comparing the frequency of genotyped genetic variants between EwS cases and ancestry-matched, cancer-free controls to identify genomic regions that are important for EwS susceptibility. This large (2,000+ cases), international consortium combines previously published data with new EwS cases to perform integrative analyses of newly discovered genetic susceptibility regions to identify local genomic structures and nearby target genes that may be important for EWS risk. The overall goal of the study is to expand understanding of EwS etiology and provide insight into improved treatment and potentially preventative measures to reduce the overall burden of EwS.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.