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2,708 results for “Microbiota”
Antimicrobial peptides modulate lung injury by altering the intestinal microbiota
<p>This repository contains the OTU tables for "Antimicrobial peptides modulate pulmonary inflammation by altering the intestinal microbiota" by Abdelgawad and Nicola et al., an analysis of the role of antimicrobial peptide in the gut-lung axis during hyperoxia-induced lung injury. This work was supported by the National Heart, Lung, and Blood Institute of the U.S. National Institutes of Health, K NIH: K08 HL151907 (KW), K08 HL141652 (CL), K08 DK120871 (AO); the Kaul Pediatric Research Institute at Children’s of Alabama (KW), and the Microbiome Center at UAB (KW). The funding agencies had no role in the design, conduct, and analysis of the study or in the decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. All data in this repository is the intellectual property of the authors and may be utilized for academic publication only with prior written permission.</p>
MMiKG: A Knowledge Graph-based Platform for Path Mining of Microbiota-Mental Diseases Interactions
<p><strong>The original datasets released in MMiKG, containing relevant information like PMID of labels and relations (triples).</strong></p> <p><strong>Background:</strong></p> <p>Gut microbiota has been demonstrated to be crucial in gut-brain axis. In this research, knowledge graphs was leveraged to aggregate and assimilate relevant information on the microbiome-gut-brain axis and its intricate relationships with mental diseases and formed a knowledge graph platform named MMiKG</p> <p> ► <strong>Advantages of MMiKG:</strong></p> <ul> <li> Assist users in semantic search and visualization operations</li> <li> Make the scattered knowledge machine-readable and interpretable</li> <li> Boost users’ confidence in the accuracy of the information</li> <li> Support better decision-making</li> </ul> <p> ► <strong>What users can do with MMiKG:</strong></p> <ul> <li>Integrate diverse resources</li> <li>Infer potential associations between gut microbiota and mental diseases</li> </ul> <p><strong>Tools:</strong></p> <p>MMiKG contains '770' entities and '1,257' triples among them. These items cover '20' common mental illnesses, '270' types of gut microbes, and '480' distinct intermediates.</p> <p> ► <strong>MMiKG's original data includes two folders:</strong></p> <p> ♦ The labels folder:</p> <ul> <li>Present information of each entity’s 'Id', 'Name', 'Degree', 'Type'</li> <li>'Disease.csv', 'Intermediate.csv', 'Microbiota.csv</li> </ul> <p> ♦ The relationships folder: </p> <ul> <li>Present information of 'SourceId', 'TargetId', 'Number', 'Reference PMID'</li> <li>'Disease.csv', 'Intermediate.csv', 'Microbiota.csv' </li> </ul>
Vertically inherited microbiota and environment-modifying behaviors indirectly shape the exaggeration of secondary sexual traits in the gazelle dung beetle
<p><span>Many organisms actively manipulate the environment</span><span> in ways that have the potential to feed back on their own development, a process referred to as developmental niche construction</span><span>. Yet, </span><span>the role that constructed biotic and abiotic environments play in shaping phenotypic variation and its evolution is insufficiently understood. Here, we assess whether environmental modifications made by developing dung beetles impact the environment-sensitive expression of secondary sexual traits</span><span>.</span> <span>Larval gazelle dung beetles both physically modify their ontogenetic environment and structure their biotic interactions through the vertical inheritance of microbial symbionts. By experimentally eliminating i) physical environmental modifications, and ii) the vertical inheritance of microbes, we assess the degree to which (sym)biotic and physical environmental modifications shape the exaggeration of several traits </span><span>varying in their degree and direction of sexual dimorphism. We expected the experimental reduction of a larva's ability to shape its environment to affect trait size and scaling, especially for traits that are sexually dimorphic and environmentally plastic</span><span>. </span><span>We find that compromised developmental niche construction indeed shapes sexual dimorphism in overall body size and the absolute sizes of male-limited exaggerated head horns, the strongly sexually dimorphic fore tibia length and width, as well as the weakly dimorphic elytron length and width. This suggests that ontogenetic environmental modifications affect sex-specific phenotypic variation in functional traits. However, most of these effects can be attributed to nutrition-dependent plasticity in size and non-isometric trait scaling, rather than body-size-independent effects on the developmental regulation of trait size. Our findings suggest that the reciprocal relationship between developing organisms, their symbionts, and their environment can have considerable impacts on sexual dimorphism and functional morphology. </span></p>
Understanding the Role of Gut Microbiota in Hyperphagia in Prader-Willi Syndrome
ClinicalTrials.gov study NCT05541003. IPD Sharing: NO. Countries: 1. Publications: 7.
Fecal Microbiota Transplantation for Pancreatitis
ClinicalTrials.gov study NCT02318134. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers
ClinicalTrials.gov study NCT05567653. IPD Sharing: NO. Countries: 1. Publications: 46.
Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infection
ClinicalTrials.gov study NCT03760484. IPD Sharing: NO. Countries: 1. Publications: 1.
Autologous Fecal Microbiota Transplantation to Prevent Antibiotic Resistant Bacteria Colonization
ClinicalTrials.gov study NCT03061097. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth
ClinicalTrials.gov study NCT05967871. IPD Sharing: YES. Countries: 1. Publications: 25.
A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing
ClinicalTrials.gov study NCT03219528. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota
ClinicalTrials.gov study NCT01473368. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fecal Microbiota Transplant for Improvement of Metabolism
ClinicalTrials.gov study NCT02530385. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metagenomic & Metabolomic Study: Bifidobacterium Probiotic Effects on Gut Microbiota & SCFA in Preterm NICU Infants
ClinicalTrials.gov study NCT07213414. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
ClinicalTrials.gov study NCT06502223. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
ClinicalTrials.gov study NCT05318183. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
ClinicalTrials.gov study NCT01198509. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Effects of Dietary Fructose on Gut Microbiota and Fecal Metabolites in Obese Men and Postmenopausal Women: A Pilot Study
ClinicalTrials.gov study NCT03339245. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection
ClinicalTrials.gov study NCT02299570. IPD Sharing: Not stated. Countries: 2. Publications: 7.
Defining the Intestinal Microbiota in Premature Neonates
ClinicalTrials.gov study NCT01102738. IPD Sharing: NO. Countries: 1. Publications: 2.
Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes
ClinicalTrials.gov study NCT07124585. IPD Sharing: YES. Countries: 1. Publications: 11.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.