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3,255 results for “Pancreatic cancer”
Hydroxychloroquine in Previously Treated Patients With Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT01273805. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Gastrointestinal, Pancreatic, or Colorectal Cancer
ClinicalTrials.gov study NCT03362177. IPD Sharing: YES. Countries: 20. Publications: 0.
A Randomized Phase 2/3 Multi-Center Study of SM-88 in Participants With Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT03512756. IPD Sharing: NO. Countries: 1. Publications: 1.
Generation of KRAS knockout pancreatic cancer cell line PANC1
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Data from: Downregulation of sST2, a decoy receptor for interleukin-33, enhances subcutaneous tumor growth in murine pancreatic cancer cells
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Data from: Engineering a spatiotemporal macrophage circuit via STING phase separation to override immune suppression in pancreatic cancer
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A mathematical model for pancreatic cancer during intraepithelial neoplasia
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Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalised therapy
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ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
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Dataset Sachindra et al: SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin αvβ6 cystine knot peptide in a pancreatic cancer xenograft model
<p>Numerical data for the manuscript 'SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin αvβ6 cystine knot peptide in a pancreatic cancer xenograft model'</p>
Data from: A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer
<p>Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5-year survival rate stands at only 12%. Triptolides have potent anti-tumor activity against different types of cancers, including pancreatic cancer, however poor solubility and toxicity limit their translation into clinical use. We synthesized a novel pro-drug of triptolide, (E)-19-[(1'-benzoyloxy-1'-phenyl)-methylidene]-Triptolide (CK21), which was formulated into an emulsion for in vitro and in vivo testing in rats and mice, and using human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids. A time-course transcriptomic profiling of tumor organoids treated with CK21 in vitro was conducted to define its mechanism of action, as well as transcriptomic profiling at a single time point post-CK21 administration in vivo. Intravenous administration of emulsified CK21 resulted in the stable release of triptolide, and potent anti-proliferative effects on human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids in vitro, and with minimal toxicity in vivo. Time course transcriptomic profiling of tumor organoids treated with CK21 in vitro revealed <10 differentially expressed genes (DEGs) at 3 h and ~8,000 DEGs at 12 h. Overall inhibition of general RNA transcription was observed, and Ingenuity pathway analysis together with functional cellular assays confirmed inhibition of the NF-κB pathway, increased oxidative phosphorylation and mitochondrial dysfunction, leading ultimately to increased reactive oxygen species (ROS) production, reduced B-cell-lymphoma protein 2 (BCL2) expression, and mitochondrial-mediated tumor cell apoptosis. CK21 is a novel pro-drug of triptolide that exerts potent anti-proliferative effects on human pancreatic tumors by inhibiting the NF-κB pathway, leading ultimately to mitochondrial-mediated tumor cell apoptosis.</p>
PP2A complex disruptor SET prompts widespread hyper-transcription of growth-essential genes in the pancreatic cancer cells
<p>Hyper-activation of the oncogenic transcription reflects the epigenetic plasticity of the cancer cells. SET was described as a nuclear factor that stimulated transcription from the chromatin template. However, the mechanisms of SET-dependent transcription are unknown. Here, we found that over-expression of SET and CDK9 induced very similar transcriptome signatures in multiple cancer cell lines. SET localized in the transcription start site (TSS)-proximal regions and supported the RNA transcription. SET specifically bound the PP2A-C subunit and induced PP2A-A subunit repulsion from the C subunit, which indicated the role of SET as a PP2A-A/C complex disruptor in the TSS-proximal regions. Through blocking PP2A activity, SET assisted CDK9 to maintain Pol II CTD phosphorylation and activated mRNA transcription. Our findings position SET as a key factor that modulates chromatin PP2A activity, promoting the oncogenic transcription in pancreatic cancer.</p>
Single Cell RNAseq Pancreatic Cancer Atlas
<p>Complete object for scRNAseq PDAC atlas.</p> <p> </p> <p>Please cite: Loveless IM, Kemp SB, Hartway KM, Mitchell JT, Wu Y, Zwernik SD, Salas-Escabillas DJ, Brender S, George M, Makinwa Y, Stockdale T, Gartrelle K, Reddy RG, Long DW, Wombwell A, Clark JM, Levin AM, Kwon D, Huang L, Francescone R, Vendramini-Costa DB, Stanger B, Alessio A, Waters AM, Cui Y, Fertig EJ, Kagohara LT, Theisen B, Crawford HC, Steele NG. Human pancreatic cancer single cell atlas reveals association of CXCL10+ fibroblasts and basal subtype tumor cells. Clin Cancer Res. 2024 Dec 5. doi: 10.1158/1078-0432.CCR-24-2183. Epub ahead of print. PMID: 39636224.. </p>
Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids
<p>Source data and source code for "Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids".</p>
Lipidomic and fatty acid metabolism changes in pancreatic cancer upon ELOVL6 inhibition
<p>LC-MS data for the analysis of lipidomic and fatty acid metabolism changes in pancreatic cancer upon ELOVL6 inhibition and MYC deletion or overexpression</p>
Magnetic resonance imaging in the assessment of pancreatic cancer with quantitative parameter extraction by means of dynamic contrast-enhanced magnetic resonance imaging, diffusion kurtosis imaging and intravoxel incoherent motion diffusion-weighted imaging
<p>We uploaded IVIM and DKI parameters values of included patients in the manuscript: Fusco, Roberta, Adele Piccirillo, Mario Sansone, Vincenza Granata, Paolo Vallone, Maria L. Barretta, Teresa Petrosino, Claudio Siani, Raimondo Di Giacomo, Maurizio Di Bonito, Gerardo Botti, and Antonella Petrillo. 2021. "Radiomic and Artificial Intelligence Analysis with Textural Metrics, Morphological and Dynamic Perfusion Features Extracted by Dynamic Contrast-Enhanced Magnetic Resonance Imaging in the Classification of Breast Lesions" Applied Sciences 11, no. 4: 1880. https://doi.org/10.3390/app11041880</p>
Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence
<p>I uploaded the original images of the manuscript Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence accepted on Cancers journal.</p>
Fig. 4 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 4. Interaction of compounds 1 (A), 2 (B) and 3 (C) with DNA sequence Seq-1. All three compounds are predicted to intercalate with the DNA base pairs.
Fig. 3 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 3. Morphological changes observed in HeLa (top row) and MIA PaCa-2 (bottom row) cells after incubation with gemcitabine (A and E), compound 1 (B and F), compound 2 (C and G) and compound 3 (D and H) at their respective IC50s for 8 h.
Fig. 2 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 2. Connectivities (bold lines) deduced by the COSY spectrum and significant HMBC correlations (solid arrows) observed for 1–9.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.