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180
datasets available to search
ShareScore release 0.9.0
Dataset results
180 results for “Polycystic Kidney Disease”
Expression data from highly efficient polycystic kidney disease cystogenesis in kidney organoids derived from CRISPR-mutant human pluripotent stem cells (hPSCs)
GEO Series GSE101308. Homo sapiens. 14 samples. Type: Expression profiling by array.
Developing a novel human adult kidney organoid model to recapitulate injury-associated regeneration and polycystic kidney disease [RNA-Seq]
GEO Series GSE228971. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Lixivaptan in a Single Subject With Intractable Pain Due to Polycystic Kidney Disease
ClinicalTrials.gov study NCT03717181. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Clinical Trial of Triptolide Woldifii for Autosomal Dominant Polycystic Kidney Disease
ClinicalTrials.gov study NCT00801268. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Endothelial Dysfunction in Adult Polycystic Kidney Disease
ClinicalTrials.gov study NCT04023214. IPD Sharing: NO. Countries: 0. Publications: 0.
A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
ClinicalTrials.gov study NCT04786574. IPD Sharing: NO. Countries: 0. Publications: 0.
The Safety and Efficacy of Catheter-based Renal Denervation Using the Vessix™ Renal Denervation System in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients With Severe Debilitating Pain
ClinicalTrials.gov study NCT02746419. IPD Sharing: NO. Countries: 0. Publications: 0.
Treat Autosomal Dominant Polycystic Kidney Disease With Oral Ketone Ester?
ClinicalTrials.gov study NCT06100133. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
IRF5 produced by kidney macrophages promotes polycystic kidney disease
GEO Series GSE127881. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The molecular landscape in autosomal dominant polycystic kidney disease is characterized by common alterations in purine metabolism
GEO Series GSE289843. Homo sapiens. 55 samples. Type: Expression profiling by high throughput sequencing.
cAMP-induced nuclear condensation of CRTC2 promotes transcription elongation and cystogenesis in autosomal dominant polycystic kidney disease (RNA-Seq)
GEO Series GSE173693. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Kidney Transcriptome and Polycystic Kidney Disease Genes in Zebrafish
GEO Series GSE224859. Danio rerio. 9 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling of the early postnatal stage of Polycystic Kidney Disease in the B6C3Fe a/a-bpck mice
GEO Series GSE34051. Mus musculus. 2 samples. Type: Expression profiling by array.
Next generation sequencing identifies WNT signalling as a significant pathway in Autosomal Recessive Polycystic Kidney Disease (ARPKD) manifestation and may be linked to disease severity
<p><em>Background: </em>Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a rare paediatric disease primarily caused by mutations in <em>PKHD1</em>. ARPKD presents with considerable clinical variability relating to the type of <em>PKHD1 </em>mutation, but not its position. Animal models of Polycystic Kidney Disease (PKD) suggest that there is a complex genetic landscape, with genetic modifiers as a potential cause of disease variability.</p> <p><em>Methods: </em>To assess this relationship, a Whole Exome Sequencing (WES) and RNA-Sequencing (RNA-Seq) approach was employed on human ARPKD kidneys and age-matched healthy controls, to investigate in an unbiased manner the molecular mechanisms of ARPKD and identify potential markers of disease severity.</p> <p><em>Results: </em>WES confirmed the clinical diagnosis of ARPKD in our patient cohort. Mutation type, nor position of <em>PKHD1 </em>mutations, were linked to disease severity. Mutations in genes associated with other ciliopathies were detected in the ARPKD cohort, but only <em>PKD1</em> could be linked to disease severity. Transcriptomic analysis identified a significant number of genes relating to WNT signalling, cellular metabolism and development. Amongst these genes, increased expression of WNT signalling-related genes was validated by RT-qPCR. In addition, two individuals in our cohort had the same <em>PKHD1</em> mutations but different rates of kidney disease progression. Amongst the transcriptomic differences of these two individuals were differences in the expression of WNT signalling genes.</p> <p><em>Conclusion: </em>ARPKD kidney transcriptomics highlights changes in WNT signalling as potentially significant in ARPKD manifestation and severity and could provide a future therapeutic target for slowing down the progression of ARPKD.</p>
cAMP-induced nuclear condensation of CRTC2 promotes transcription elongation and cystogenesis in autosomal dominant polycystic kidney disease
GEO Series GSE173695. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic silencing of PKD1 in autosomal dominant polycystic kidney disease
GEO Series GSE35831. Homo sapiens. 3 samples. Type: Expression profiling by array.
cAMP-induced nuclear condensation of CRTC2 promotes transcription elongation and cystogenesis in autosomal dominant polycystic kidney disease (ChIP-Seq)
GEO Series GSE173694. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease
<p>These databases are from the pilot clinical trial, Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease. This study determined the feasibility of delivering two behavioral weight loss interventions for 1 year in adults with autosomal dominant polycystic kidney disease (ADPKD) who were overweight or obese. The study also compared these two interventions in terms of safety, acceptability, and tolerability. Last, the trial will provided initial insight into a) biological changes and b) changes in kidney growth with each of the two weight loss interventions. The main data are provided as a SAS files (with data dictionaries), with adherence data as a SPSS file. The data are available to qualified individuals within the scientific community who apply for data use directly with the lead contact. </p>
Cerebrovascular Function in Autosomal Dominant Polycystic Kidney Disease
<p>Dataset for manuscript: Cerebrovascular Function in Autosomal Dominant Polycystic Kidney Disease</p>
Changes in Tubular Biomarkers with Dietary Intervention and Metformin in Patients with Autosomal Dominant Polycystic Kidney Disease
<p>Data associated with mansucript: Changes in Tubular Biomarkers with Dietary Intervention and Metformin in Patients with Autosomal Dominant Polycystic Kidney Disease</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.