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237
datasets available to search
ShareScore release 0.9.0
Dataset results
237 results for “animal models”
Pregnancy enables expansion of autoreactive regulatory T cells in an animal model of multiple sclerosis
GEO Series GSE122894. Mus musculus. 46 samples. Type: Other.
Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis
GEO Series GSE81139. Mus musculus. 71 samples. Type: Non-coding RNA profiling by array.
Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
GEO Series GSE123467. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Data from: Big data analysis of genes associated with neuropsychiatric disorders in an Alzheimer's disease animal model
Alzheimer's disease is a neurodegenerative disease characterized by the impairment of cognitive function and loss of memory, affecting millions of individuals worldwide. With the dramatic increase in the prevalence of Alzheimer's disease, it is expected to impose extensive public health and economic burden. However, this burden is particularly heavy on the caregivers of Alzheimer's disease patients eliciting neuropsychiatric symptoms that include mood swings, hallucinations, and depression. Interestingly, these neuropsychiatric symptoms are shared across symptoms of bipolar disorder, schizophrenia, and major depression disorder. Despite the similarities in symptomatology, comorbidities of Alzheimer's disease and these neuropsychiatric disorders have not been studied in the Alzheimer's disease model. Here, we explore the comprehensive changes in gene expression of genes that are associated with bipolar disorder, schizophrenia, and major depression disorder through the microarray of an Alzheimer's disease animal model, the forebrain specific PSEN double knockout mouse. To analyze the genes related with these three neuropsychiatric disorders within the scope of our microarray data, we used selected 1207 of a total of 45,037 genes that satisfied our selection criteria. These genes were selected on the basis of 14 Gene Ontology terms significantly relevant with the three disorders which were identified by previous research conducted by the Psychiatric Genomics Consortium. Our study revealed that the forebrain specific deletion of Alzheimer's disease genes can significantly alter neuropsychiatric disorder associated genes. Most importantly, most of these significantly altered genes were found to be involved with schizophrenia. Taken together, we suggest that the synaptic dysfunction by mutation of Alzheimer's disease genes can lead to the manifestation of not only memory loss and impairments in cognition, but also neuropsychiatric symptoms.
MRAMS mesoscale model dataset, tools and animations for Jezero crater nighttime turbulence analysis
<p>This material constitutes the software tools to generate MRAMS data used in the analysis submitted for publication in JGR:Planets</p> <p>"Nocturnal turbulence at Jezero crater as determined from MEDA measurements and modeling"<br> by Pla-Garcia et al.</p> <p>The manuscript was submitted to JGR: Planets on 2 October, 2022</p>
3D Animation and Models to Aid Management of Fetal CDH
ClinicalTrials.gov study NCT03750266. IPD Sharing: NO. Countries: 1. Publications: 0.
Animal model of acute-on-chronic alcoholic liver injury
GEO Series GSE119470. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence
GEO Series GSE241903. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
PNET animal model: new insights
GEO Series GSE82102. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
NAD+ - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal models
GEO Series GSE279334. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Data from: Predicting local and non-local effects of resources on animal space use using a mechanistic step-selection model
Open the record for dataset details and reuse information.
Data from: Big data analysis of genes associated with neuropsychiatric disorders in an Alzheimer's disease animal model
Open the record for dataset details and reuse information.
DNA methylation profile in animal models of neurodevelopmental disorders treated with TAK-418
GEO Series GSE165675. Mus musculus; Rattus norvegicus. 18 samples. Type: Methylation profiling by high throughput sequencing.
Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model
GEO Series GSE113693. Mus musculus. 2 samples. Type: Expression profiling by array.
Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients
GEO Series GSE26605. Homo sapiens. 26 samples. Type: Expression profiling by array.
Effect of estrogen receptor alpha (ERα) signaling in dendritic cells in modulating autoimmune disease phenotype in animal model of Multiple Sclerosis
GEO Series GSE215238. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
miR-34a negatively regulates alveolarization in a BPD animal model
GEO Series GSE89730. Mus musculus. 32 samples. Type: Expression profiling by array.
Tau exacerbates excitotoxic brain damage in an animal model of stroke
GEO Series GSE45703. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome [ssRNA-seq]
GEO Series GSE116358. Danio rerio. 5 samples. Type: Expression profiling by high throughput sequencing.
Dynamic alterations of dural and bone marrow B cells in an animal model of progressive MS
GEO Series GSE299404. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.