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1,554 results for “nucleus”
Data from: Mapping movement, mood, motivation, and mentation in the subthalamic nucleus
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Data from: An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics
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Data from: Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus
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Single-nucleus RNA-sequencing in pre-cellularization Drosophila melanogaster embryos
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Therapeutic Deep Brain Stimulation Disrupts Subthalamic Nucleus Activity Dynamics in Parkinsonian Mice
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Full summary statistics of mixQTL for GTEx v8 Brain_Nucleus_accumbens_basal_ganglia
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Data from: Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus
Directional cell migration in dense three-dimensional (3D) environments critically depends upon shape adaptation and is impeded depending on the size and rigidity of the nucleus. Accordingly, the nucleus is primarily understood as a physical obstacle, however, its pro-migratory functions by step-wise deformation and reshaping remain unclear. Using atomic force spectroscopy, time-lapse fluorescence microscopy and shape change analysis tools, we determined nuclear size, deformability, morphology and shape change of HT1080 fibrosarcoma cells expressing the Fucci cell cycle indicator or being pre-treated with chromatin-decondensating agent TSA. We show oscillating peak accelerations during migration through 3D collagen matrices and microdevices that occur during shape reversion of deformed nuclei (recoil), and increase with confinement. During G1 cell cycle phase, nucleus stiffness was increased and yielded further increased speed fluctuations together with sustained cell migration rates in confinement as compared to interphase populations, or to periods of intrinsic nuclear softening in the S/G2 cell cycle phase. Likewise, nuclear softening by pharmacological chromatin decondensation or after lamin A/C depletion reduced peak oscillations in confinement. In conclusion, deformation and recoil of the stiff nucleus contributes to saltatory locomotion in dense tissues.
Data from: Sex-specific gene expression in the mouse nucleus accumbens before and after cocaine exposure
Females are more sensitive than males to the addictive effects of cocaine and are more likely to relapse. The nucleus accumbens has a well-established major role in the response to cocaine, and sex-specific differential expression of key transcripts at baseline and after cocaine withdrawal could underlie some of these differences. To address this hypothesis, four groups of mice (cycling females, ovariectomized females treated with estradiol or placebo and males) were evaluated for open field activity following 7 daily injections of saline or cocaine. Sensitization to the locomotor effects of cocaine was most pronounced in ovariectomized mice receiving estradiol, was greater in cycling females than in males, and failed to occur in ovariectomized/placebo mice. After a 28-day period of withdrawal, RNA prepared from the nucleus accumbens of individual cocaine or saline injected mice was subjected to RNASeq analysis. Expression of a substantial fraction of the transcripts expressed in the nucleus accumbens (~3%) differed in cycling female mice when compared to male mice, was altered by ovariectomy or was responsive to estradiol treatment. The transcripts differentially expressed in the nucleus accumbens of cycling female mice withdrawn from cocaine for 28-days exhibited substantial overlap with those differentially expressed in the nucleus accumbens of male mice withdrawn for 7-days. A small set of transcripts were similarly affected by cocaine in placebo or estradiol treated ovariectomized mice. Transcripts differentially expressed after 28-days of withdrawal encoded neprilysin, which degrades enkephalin and other neuropeptides, G protein coupled receptors and secreted proteins such as Wnt2, Fst and Igfbp4.
Data from: Regional difference in sex steroid action on formation of morphological sex differences in the anteroventral periventricular nucleus and principal nucleus of the bed nucleus of the stria terminalis
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understood. We previously reported that masculinization of the principal nucleus of the bed nucleus of the stria terminalis (BNSTp), which is larger and has more neurons in males than in females, involves aromatized testosterone that acts via estrogen receptor-α (ERα), but not estrogen receptor-β (ERβ). Here, we examined sex steroid action on the formation of the anteroventral periventricular nucleus (AVPV) that is larger and has more neurons in females. Morphometrical analysis of transgenic mice lacking aromatase, ERα, or ERβ genes revealed that the volume and neuron number of the male AVPV were significantly increased by deletion of aromatase and ERα genes, but not the ERβ gene. We further examined the AVPV and BNSTp of androgen receptor knockout (ARKO) mice. The volume and neuron number of the male BNSTp were smaller in ARKO mice than those in wild-type mice, while no significant effect of ARKO was found on the AVPV and female BNSTp. We also examined aromatase, ERα, and AR mRNA levels in the AVPV and BNSTp of wild-type and ARKO mice on embryonic day (ED) 18 and postnatal day (PD) 4. AR mRNA in the BNSTp and AVPV of wild-type mice was not expressed on ED18 and emerged on PD4. In the AVPV, the aromatase mRNA level was higher on ED18, although the ERα mRNA level was higher on PD4 without any effect of AR gene deletion. Aromatase and ERα mRNA levels in the male BNSTp were significantly increased on PD4 by AR gene deletion. These results suggest that estradiol signaling via ERα during the perinatal period and testosterone signaling via AR during the postnatal period are required for masculinization of the BNSTp, whereas the former is sufficient to defeminize the AVPV.
nucleus
nucleus à éclats (paléolithique moyen ?) Source: Objaverse 1.0 / Sketchfab
Nucleus Pierre Taillée
Pierre Taillée nucléus Point et onde de choc Source: Objaverse 1.0 / Sketchfab
Freezing nucleus spectra for hailstone samples in China from droplet freezing experiments—Data
<p>INP concentrations in hailstone samples from droplet freezing experiments.</p>
An integrated single-cell RNA-seq atlas of the mouse hypothalamic paraventricular nucleus links transcriptional and function types
<p>The hypothalamic paraventricular nucleus (PVN) is a highly complex brain region that is crucial for homeostatic<br> regulation through neuroendocrine signalling, outflow of the autonomic nervous system (ANS), and projections<br> to other brain areas. The past years, single-cell datasets of the hypothalamus have contributed immensely<br> to the current understanding of the diverse hypothalamic cellular composition. While the PVN has been<br> adequately classified functionally, its molecular classification is currently still insufficient.</p> <p>To address this, we created a detailed atlas of PVN transcriptional cell types by integrating various PVN<br> single-cell datasets into a recently published hypothalamus single-cell transcriptome atlas. Furthermore, we<br> functionally profiled transcriptional cell types, based on relevant literature, existing retrograde tracing data<br> and existing single-cell data of a PVN-projection target region.</p>
Nucleus Independent Chemical Shift Example Data
<p>Dataset and scripts to run NICS calculations on example data.</p>
Single nucleus sequencing analysis of rat hippocampus reveals the landscape of latent phase temporal lobe epilepsy
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◂Fig. 5 Cells of phylogenetically related strains (light microscopy). a Thecate cell in dorsal view. b Thecate cell in ventral view, note the sulcus extending onto the epitheca (arrow). c Putatively necrotic, thecate cell. d Thecate cell with one bulge on the epitheca (arrow), note that this was the only such cell among thousands of inspected cells. e, f Coccoid cells, apparently without thecae. g Two thecate cells enclosed in the parental theca. h Two connected, immotile cells enclosed in the parental thecae. j Lid of epitheca in dorsal-apical view (mirrored), composed of plates 2′‒4′, all intercalary plates and plates 2′′‒6′′. l‒m Same opened theca in ventral view (l) and dorsal view (m), note the sulcus extending onto the epitheca (arrow), the dorsal opening and all apical and all intercalary plates and plates 3′′‒5′′ remaining with the hypotheca. n Chloroplasts (as inferred from autofluorescence), note the space occupied by the nucleus. Plate labelling follows the Kofoidean notation, n′: apical plate; n′′: precingular plate; n′′′: postcingular plate; na: anterior intercalary plate. Scale= 10 µm in Bumps on the back: An unusual morphology in phylogenetically distinct Peridinium aff. cinctum (= Peridinium tuberosum; Peridiniales, Dinophyceae)
◂Fig. 5 Cells of phylogenetically related strains (light microscopy). a Thecate cell in dorsal view. b Thecate cell in ventral view, note the sulcus extending onto the epitheca (arrow). c Putatively necrotic, thecate cell. d Thecate cell with one bulge on the epitheca (arrow), note that this was the only such cell among thousands of inspected cells. e, f Coccoid cells, apparently without thecae. g Two thecate cells enclosed in the parental theca. h Two connected, immotile cells enclosed in the parental thecae. j Lid of epitheca in dorsal-apical view (mirrored), composed of plates 2′‒4′, all intercalary plates and plates 2′′‒6′′. l‒m Same opened theca in ventral view (l) and dorsal view (m), note the sulcus extending onto the epitheca (arrow), the dorsal opening and all apical and all intercalary plates and plates 3′′‒5′′ remaining with the hypotheca. n Chloroplasts (as inferred from autofluorescence), note the space occupied by the nucleus. Plate labelling follows the Kofoidean notation, n′: apical plate; n′′: precingular plate; n′′′: postcingular plate; na: anterior intercalary plate. Scale= 10 µm
scCDC: a computational method for gene-specific contamination detection and correction in single-cell and single-nucleus RNA-seq data
<p><span>In droplet-based single-cell and single-nucleus RNA-seq assays, systematic contamination of ambient RNA molecules biases the quantification of gene expression levels. Existing methods correct the contamination for all genes globally. However, specific evaluation for different contamination levels is lacking. Here, we show that DecontX and CellBender under-correct highly-contaminating genes, while SoupX and scAR over-correct lowly-/non-contaminating genes. Here, we develop scCDC as the first method to detect the contamination-causing genes and only correct expression levels of these genes, some of which are cell-type markers. Compared with existing decontamination methods, scCDC excels in decontaminating highly-contaminating genes while avoiding over-correction of other genes.</span></p>
Data from: Local fields in human subthalamic nucleus track the lead-up to impulsive choices
The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding. Here, we address this challenge by recording from multiple independent channels within the STN in a self-paced decision task to test whether these signals carry information sufficient to predict stopping behavior on a trial-by-trial basis. As in previous studies, we found that local field potentials (LFPs) exhibited modulations preceding self-initiated movements, with power ramping across multiple frequencies during the deliberation period. In addition, signals showed phasic changes in power around the time of decision. However, a prospective model that attempted to use these signals to predict decision times showed effects of risk level did not improve with the addition of LFPs as regressors. These findings suggest information tracking the lead-up to impulsive choices is distributed across multiple frequency scales in STN, though current techniques may not possess sufficient signal-to-noise ratios to predict—and thus curb—impulsive behavior on a moment-to-moment basis.
EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease
ClinicalTrials.gov study NCT07168603. IPD Sharing: NO. Countries: 0. Publications: 0.
Safety and Efficacy of the Cochlear Nucleus CI422 Cochlear Implant in Adults
ClinicalTrials.gov study NCT01867008. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.