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opencc-by-4.0Nov 2023View details →

Vitamin D Deficiency and Pregnancy Outcome: A longitudinal Interventional Study

<p><strong><u><span>ABSTRACT</span></u></strong><span>:</span></p> <p><strong><span>Introduction:</span></strong><span> <span>Vitamin D is a fat-soluble vitamin responsible for increasing the absorption of calcium, magnesium, phosphate, and multiple other biological effects. Deficiency of vitamin D is a common global problem, especially in females. It is naturally produced by the body on exposure to sunlight. Deficiency of vitamin D in pregnancy predisposes to pre-eclampsia, GDM, preterm birth to the mother, hypocalcemic tetany, low birth weight, and congenital rickets in the fetus. In general, 10 (400) units of vitamin D are recommended for all pregnant women per day.</span></span><span> <strong><span>Materials and methods:</span></strong> The study was conducted in the OBGY department of MGM Medical College, Aurangabad, Maharashtra, between August 2022 to August 2023. A complete procedure was explained to all the second-trimester pregnant women willing to participate in this study, and informed written consent was obtained from them. Their detailed history was taken and subjected to an estimation of 25 hydroxyvitamin D and serum calcium. <strong><span>Results:</span></strong> A high prevalence of vitamin D deficiency is found (81%). In teenage pregnancy, the occurrence of vitamin D deficiency is higher. In our study, vitamin D deficiency was more prevalent in rural areas thanurban areas. It was more in the Muslim population. A sedentary life is prone to vitamin D deficiency. The incidence of GDM, pre-eclampsia, and low birth weight was significantly lower in tested and treated patients. Empirical vitamin D supplementation should be given to each pregnant patient.</span></p> <p><strong><em><span> </span></em></strong></p> <p><strong><em><span>Keywords: GDM, Preeclampsia, prevalence, teenage pregnancy, low birth weight.</span></em></strong></p> <p><span> </span></p>

opencc-by-4.0Dec 2023View details →

Psychometric properties of Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE®) in breast cancer patients: the prospective observational multicenter VIP study.

<p>Dataset for the proposed manuscript Psychometric properties of Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE®) in breast cancer patients: the prospective observational multicenter VIP study. </p>

opencc-zeroMay 2024View details →

Inter-Chemical Correlation results for the study: HHEARx2018-2273 (First Trimester Exposures: Influence on Birth Outcomes and Markers of Biological Response)

Title: First Trimester Exposures: Influence on Birth Outcomes and Markers of Biological Response <br>Species: Homo sapiens <br>Number of samples: 356 <br>Number of named analytes: 59 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=59 <br>

opencc-by-4.0Dec 2021View details →

Considerations on baseline generation for Imaging AI studies illustrated on the CT-based prediction of empyema and outcome assessment.

<p><strong>Considerations on baseline generation for Imaging AI studies illustrated on the CT-based prediction of empyema and outcome assessment.</strong></p> <p><strong>Introduction</strong>: For AI-based classification tasks in computed tomography, a reference standard for evaluating the clinical diagnostic accuracy of individual classes is essential. To enable the implementation of an AI tool in clinical practice, this should be drawn from clinical routine data, using State-of-the-art scanners, evaluated in a blinded manner, and verified with a reference test.</p> <p><strong>Methods: </strong>2659 consecutive CTs performed between 01/2016 and 01/2021 with reported pleural effusion were retrospectively included. Pathology reports from thoracocentesis or biopsy within 7 days of CT were used as reference standard (n = 335). Two radiologists (4 and 10 PGY) blindly assessed chest CTs (n=335, 81 empyemas) for pleural CT features and ICC was determined. In addition, both pleural CT features and radiological diagnosis were extracted from written radiological reports. If needed, consensus was achieved using an experienced radiologist's opinion (29 PGY). We assessed the correlation of these findings with the following patient outcomes: mortality and median hospital stay.</p> <p><strong>Results: </strong>Specificity and sensitivity for clinical detection of empyema (N=81) were 90.94 (95%-CI 86.55-94.05) and 72.84 (95%-CI: 61.63-81.85%) in all effusions, with moderate to almost perfect interrater agreement for all pleural findings associated with empyema (Cohen's kappa = 0.41-0.82). Features describing pleural enhancement or thickening achieved the highest accuracy with 87.02% and 81.49%, respectively. Empyema was associated with a longer hospital stay (median= 20 versus 14 days), and findings consistent with pleural carcinosis impacted mortality. </p>

opencc-by-4.0Feb 2022View details →

Contrast MR Based Radiomics and Machine Learning Analysis to assess clinical outcomes following liver resec-tion in Colorectal Liver Metastases: a preliminary study

<p>We uploaded the images of the manuscript "Contrast MR Based Radiomics and Machine Learning Analysis to assess clinical outcomes following liver resection in Colorectal Liver Metastases: a preliminary study" accepted on Cancers.</p> <p>Vincenza Granata1*, Roberta Fusco2, Federica De Muzio3, Carmen Cutolo4, Sergio Venanzio Setola1, Federica dell’ Aversana5, Alessandro Ottaiano6, Antonio Avallone6, Guglielmo Nasti6, Francesca Grassi5, Vincenzo Pilone4, Vittorio Miele7-8, Luca Brunese3, Francesco Izzo9, Antonella Petrillo1</p> <p>1Division of Radiology, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”, Naples, Italy</p> <p>2Medical Oncology Division, Igea SpA, Napoli, Italy</p> <p>3Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy</p> <p>4Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy</p> <p>5Division of Radiology, “Università degli Studi della Campania Luigi Vanvitelli”, Naples, Italy</p> <p>.6Division of Abdominal Oncology, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”, Naples, Italy</p> <p>7Division of Radiology, “Azienda Ospedaliera Universitaria Careggi”, Florence, Italy</p> <p>8Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, via della Signora 2, 20122 Milan, Italy</p> <p>9Division of Epatobiliary Surgical Oncology,“Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”, Naples, Italy</p> <p> </p>

opencc-zeroMar 2022View details →

Supplemental material for: Clinical and neuroimaging outcomes of direct endovascular thrombectomy vs. bridging therapy in large vessel occlusion patients: a secondary analysis of SELECT cohort study

<p><b>Objective:</b> To evaluate the comparative safety and efficacy of direct endovascular thrombectomy(dEVT) compared to bridging therapy(BT:IV-tPA+EVT) and assess if BT potential benefit relates to stroke severity, size and initial presentation to EVT vs. non-EVT center.</p> <p><b>Methods:</b> In a prospective multicenter cohort-study of imaging selection for endovascular thrombectomy[SELECT], anterior-circulation large vessel occlusion (LVO) patients presenting to EVT-capable centers within 4.5hours from last-known-well were stratified into BT vs. dEVT.<b><i> </i></b>The primary outcome was 90-day functional independence[modified Rankin Scale(mRS)=0-2]. Secondary outcomes included a shift across 90-day mRS grades, mortality, symptomatic intracranial hemorrhage. We also performed subgroup-analyses according to initial presentation to EVT-capable center (direct versus transfer), stroke severity and baseline infarct core volume.</p> <p><b>Results:</b> We identified 226 LVOs (54%:men, mean age:65.6±14.6years, median NIHSS-score: 17, 28% received dEVT). Median time from arrival to groin-puncture did not differ in BT-patients when presenting directly[dEVT:1.43 (IQR=1.13-1.90) hours vs. BT:1.58(IQR=1.27-2.02)hours,p=0.40] or transferred to EVT-capable centers[dEVT:1.17 (IQR: 0.90-1.48) hours vs. BT:1.27 (IQR: 0.97-1.87) hours,p=0.24]. BT was associated with higher odds of 90-day functional independence (57% vs. 44%,aOR=2.02,95%CI:1.01-4.03,p=0.046) and functional improvement (adjusted cOR=2.06,95%CI:1.18-3.60,p=0.011), and lower likelihood of 90-day mortality (11% vs. 23%,aOR: 0.20,95%CI:0.07-0.58,p=0.003). No differences in any other outcomes were detected. In subgroup-analyses, BT patients with baseline NIHSS-scores<15 had higher functional independence likelihood compared to dEVT (aOR=4.87,95%CI:1.56-15.18,p=0.006); this association was not evident for patients with NIHSS-scores≥15 (aOR=1.05,95%CI:0.40-2.74,p=0.92). Similarly, functional outcomes improvements with BT were detected in patients with core volume strata (Ischemic core <50cc: aOR: 2.10, 95% CI:1.02-4.33, p=0.044 vs ischemic core ≥50cc: aOR: 0.41,95% CI:0.01-16.02,p=0.64) and transfer status (transferred: aOR: 2.21,95% CI:0.93-9.65,p=0.29 vs direct to EVT center: aOR:1.84,95%CI:0.80-4.23,p=0.15). </p> <p><b>Conclusions:</b> Bridging therapy appears to be associated with better clinical outcomes, especially with milder NIHSS-scores, smaller presentation core volumes and those who were "dripped and shipped".</p> <p><b>Classification of Evidence: </b>This study provides Class III evidence that for patients with ischemic stroke from anterior-circulation LVO within 4.5 hours from last-known-well, bridging therapy compared to direct endovascular thrombectomy leads to better 90-day functional outcomes.</p>

opencc-zeroAug 2022View details →

Coronary atherosclerotic burden assessed by SYNTAX scores and outcomes in surgical, percutaneous, or medical strategies: A retrospective cohort study

<div><span><strong>Introduction</strong></span></div> <div> </div> <div> <span>Coronary atherosclerotic burden and SYNTAX score (SS) are predictors of cardiovascular events.</span> </div> <div> </div> <div><span><strong>Objectives</strong></span></div> <div> </div> <div> <span>To investigate the value of SYNTAX scores (SS, SSII and residual SS [rSS]) for predicting cardiovascular events in patients with coronary artery disease (CAD).</span> </div> <div> </div> <div><strong><span>Design</span></strong></div> <div> </div> <div> <span>Retrospective cohort study.</span> </div> <div> </div> <div><strong><span>Setting</span></strong></div> <div> </div> <div> <span>Single tertiary centre.</span> </div> <div><strong> </strong></div> <div><strong><span>Participants</span></strong></div> <div> </div> <div> <span>Medicine, Angioplasty or Surgery Study (MASS) database patients with stable multivessel CAD and preserved ejection fraction.</span> </div> <div> </div> <div> <span>Interventions</span><span> CAD patients undergoing coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI), or medical treatment (MT) alone from January 2002 to December 2015.</span> </div> <div> </div> <div> <span>Primary and secondary outcomes</span><span> Primary: 5-year all-cause mortality. Secondary: composite of all-cause death, myocardial infarction, stroke, and subsequent coronary revascularization at 5 years.</span> </div> <div> </div> <div><strong><span>Results</span></strong></div> <div> </div> <div> <span>A total of 1,719 patients underwent PCI (n = 573), CABG (n = 572), or MT (n = 574) alone. </span><span>The SS was not considered an independent predictor of 5-year mortality in the PCI </span><span>(low, intermediate and high SS 6.5%, 6.8% and 4.3%, respectively, p=0.745)</span><span>, CABG </span><span>(low, intermediate and high SS 5.7%, 8.0% and 12.1%, respectively, p=0.194)</span><span> and MT </span><span>(low, intermediate and high SS 6.8%, 6.9% and 6.5%, respectively, p=0.993)</span><span> cohorts. The SSII (low, intermediate and high SSII, 3.6% vs. 7.9% vs. 10.5%, respectively, p <0.001) was associated with a higher mortality risk in the overall population. Within each treatment strategy, SSII was associated with a significant 5-year mortality rate, especially in CABG patients with higher SSII (</span><span>low, intermediate and high SSII, </span><span>1.8%, 9.7% and 10.0%, respectively, </span><span>p = 0.004) and in MT patients with high SSII (</span><span>low, intermediate and high SSII, 5.0%, 4.7% and 10.8%, respectively,</span><span> p = 0.031). </span><span>SSII demonstrated a better predictive accuracy for mortality compared with SS and rSS </span><span>(c-index = 0.62)</span><span>. </span> </div> <div> </div> <div><span><strong>Conclusions</strong></span></div> <div> </div> <div><span>Coronary atherosclerotic burden alone was not associated with significantly increased risk of all-cause mortality. The SSII better discriminates the risk of death. </span></div>

opencc-zeroJul 2024View details →

Data from: Clinical outcomes and safety of polymyxin B versus tigecycline combination therapy for pneumonia of carbapenem-resistant Klebsiella pneumoniae: A retrospective cohort study

<p><strong>Purpose:</strong> Infection by carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) has high mortality. There is no clear optimal therapeutic choice for pneumonia caused by CRKP. The aim of this study was to compare the clinical outcomes and safety of the standard doses of polymyxin B-based regimens vs tigecycline-based regimens and to identify risk factors for mortality.</p> <p><strong>Methods:</strong><strong> </strong>This retrospective cohort study included patients with pneumonia caused by CRKP for three years. The primary outcomes were 7-day bacterial eradication rate and 14- and 28-day all-cause mortality. The secondary outcome was incidence of acute kidney injury.</p> <p><strong>Results:</strong><strong> </strong>Seventy-three patients were included in this study, 29 in the<strong> </strong>polymyxin B-based combination therapy group and 44 in tigecycline-based combination therapy group. There were no significant differences between the two groups in terms of the 7-day bacterial eradication rate (31.0% vs 20.5%, <em>P</em>=0.409), the 14-day all-cause mortality (37.9% vs 22.7%, <em>P</em>=0.160), and the incidence of acute kidney injury (14.3% vs 6.8%, <em>P</em>=0.526). The 28-day all-cause mortality in the polymyxin B-based therapy group was higher than in the tigecycline-based group (75.9% vs 45.5%, <em>P</em>=0.010). Binary logistic regression analysis revealed that male and previous use of carbapenems were independent factors associated with 28-day all-cause mortality for patients treated with polymyxin B (<em>P</em><0.05).</p> <p><strong>Conclusions:</strong><strong> </strong>Polymyxin B-based combination therapy at the standard dose should be used with caution for patients with CRKP-induced pneumonia, especially for men who used carbapenems prior to CRKP detection.</p>

opencc-by-4.0Aug 2024View details →

Forest plots of pairwise comparisons from original studies for the primary outcomes

<p>Supplemental File #9 for the Cochrane review entitled: "<span>Non-invasive respiratory support in preterm infants as primary mode: a network meta-analysis"</span></p>

opencc-by-4.0Sep 2024View details →

Studying Therapy Effects and Disease Outcomes in Silico using Artificial Counterfactual Tissue Samples

<p>Counterfactual samples created by our generative method the CF-HistoGAN introduced in https://doi.org/10.48550/arXiv.2302.03120. This model was trained on and transformed data from 2 different datasets: the colorectal cancer (CRC) dataset by Schürch et al. https://doi.org/10.1016/j.cell. 2020.07.005 and the cutaneous T cell lymphoma (CTCL) by (Phillips et al https://doi.org/10.1038/s41467-021-26974-6.</p>

opencc-zeroDec 2015View details →

Data from: Characteristics and outcomes of women utilizing emergency medical services for third-trimester pregnancy-related complaints in India: a prospective observational study

Objectives: Characterize the demographics, management, and outcomes of obstetric patients transported by emergency medical services (EMS). Design: Prospective observational study. Setting: Five Indian states utilizing a centralized EMS agency that transported 3.1 million pregnant women in 2014. Participants: This study enrolled a convenience sample of 1684 women in third trimester of pregnancy calling with a "pregnancy-related" complaint for free-of-charge ambulance transport. Calls were deemed "pregnancy-related" if categorized by EMS dispatchers as "pregnancy", "childbirth", "miscarriage", or "labor pains". Interfacility transfers, patients absent upon ambulance arrival, and patients refusing care were excluded. Main outcome measures: Emergency medical technician (EMT) interventions, method of delivery, and death. Results: The median age enrolled was 23 years (IQR 21-25). Women were primarily from rural/tribal areas (1550/1684 (92.0%)) and lower economic strata (1177/1684 (69.9%)). Time from initial call to hospital arrival was longer for rural/tribal compared to urban patients (66 min (IQR 51-84) vs 56 min (IQR 42-73), respectively, p<0.0001). EMTs assisted delivery in 44 women, delivering the placenta in 33/44 (75%), performing transabdominal uterine massage in 29/33 (87.9%), and administering oxytocin in none (0%). There were 1411 recorded deliveries. Most women delivered at a hospital (1212/1411 (85.9%)), however 126/1411 (8.9%) delivered at home following hospital discharge. Follow-up rates at 48 hours, 7 days, and 42 days were 95.0%, 94.4%, and 94.1%, respectively. Four women died, all within 48 hours. The cesarean section rate was 8.2% (116/1411). On multivariate regression analysis, women transported to private hospitals versus government primary health centers were less likely to deliver by cesarean section (odds ratio 0.14 (0.05 to 0.43)). Conclusions: Pregnant women from vulnerable Indian populations use free-of-charge EMS for impending delivery, making it integral to the health care system. Future research and health system planning should focus on strengthening and expanding EMS as a component of EmONC.

opencc-zeroDec 2015View details →

Data from: Studying long-term, large-scale grassland restoration outcomes to improve seeding methods and reveal knowledge gaps

Studies are increasingly investigating effects of large-scale management activities on grassland restoration outcomes. These studies are providing useful comparisons among currently used management strategies, but not the novel strategies needed to rapidly improve restoration efforts. Here we illustrate how managing restoration projects adaptively can allow promising management innovations to be identified and tested. We studied 327 Great Plains fields seeded after coal mining. We modelled plant responses to management strategies to identify the most effective previously used strategies for constraining weeds and establishing desired plants. Then, we used the model to predict responses to new strategies our analysis identified as potentially more effective. Where established, the weed crested wheatgrass (Agropyron cristatum L.) increased through time, indicating a need to manage establishment of this grass. Seeding particular grasses reduced annual weed cover, and because these grasses appeared to become similarly abundant whether sown at low or high rates, low rates could likely be safely used to reduce seeding costs. More importantly, lower than average grass seed rates increased cover of shrubs, the plants most difficult to restore to many grassland ecosystems. After identifying grass seed rates as a driver, we formulated model predictions for rates below the range managers typically use. These predictions require testing but indicated atypically low grass seed rates would further increase shrubs without hindering long-term grass stand development. Synthesis and applications. Designing management around empirically based predictions is a logical next step towards improving ecological restoration efforts. Our predictions are that reducing grass seed rates to atypically low levels will boost shrubs without compromising grasses. Because these predictions derive from the fitted model, they represent quantitative hypotheses based on current understanding of the system. Generating data needed to test and update these hypotheses will require monitoring responses to shifts in management, specifically shifts to lower grass seed rates. A paucity of data for confronting hypotheses has been a major sticking point hindering adaptive management of most natural resources, but this need not be the case with degraded grasslands, because ongoing restoration efforts around the globe are providing continuous opportunities to monitor and manage processes regulating grassland restoration outcomes.

opencc-by-4.0Jan 2023View details →

Dataset: Stunting and Its Association with Education and Cognitive Outcomes in Adulthood: A Longitudinal Study in Indonesia

<p>Abstract</p> <p>Stunting is associated with adverse outcomes in adulthood. This article specifically aims to analyse the relationship between childhood stunting and education as well as cognitive outcomes for adults in Indonesia. Pooled data from two waves of the Indonesia Family Life Survey in 1993 and 1997, identified 4851 children aged 0-5 by their stunting status as well as their relative height to be compared for their differences in educational outcomes and cognitive abilities in 2014. Height-for-age z-score was used to proxy relative height and determine stunting status based on 2006 WHO child’s growth standards. The outcomes for education and cognitive abilities include educational levels, years of schooling, age of school entry, failing a grade, and scores for cognitive tests. The study employs estimation models of pooled regressions and instrumental variables. Stunting and relatively small stature had a significant association with cognitive development, and they worked as an intermediary to cognitive developmental barriers manifested in reduced educational outcomes. A lack of one SD in height-for-age was associated with a 0.125-point reduction in education level, 0.4 years shortened length of the school, 6% higher chances of failing grades and dropouts from secondary school, and 0.19-0.24 SD lowered cognitive and numerical scores. Similarly, stunting tends to decrease cognitive test scores by 0.56-0.8 SD compared to non-stunting and reduce educational achievement by 0.38 points, 1.4 years shorter schooling, 17.7% and 23% more likely to fail grades. In addition, HAZ and stunting are also associated with the school entry age of 0.35 and 0.11 years, respectively.</p>

opencc-by-4.0Feb 2023View details →

Underlying data for The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study

<p>Underlying data for The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study</p>

opencc-by-4.0Feb 2023View details →

STROBE checklist for: The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study

<p>STROBE checklist for: The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study</p>

opencc-by-4.0Jul 2023View details →

CONCORDANCE OF BRONCHOSCOPIC AND RADIOLOGICAL FINDINGS IN SUSPECTED LUNG CANCER AND ITS OUTCOME- A CROSS SECTIONAL STUDY IN A TERTIARY CARE HOSPITAL

<p>Background</p> <p>Bronchoscopy and CT thorax are the most common investigations utilized to screen and diagnose lung cancer. Their individual utility in diagnosing lung cancer has been described affirmatively in existing literature. Studies correlating the airway characteristics of the two modalities in lung cancer are few.</p> <p>Objectives</p> <p>To analyze and characterize lung lesions bronchoscopically and correlate the same radiologically by CT of the thorax and thus assess its positive predictive value.</p> <p>Methods</p> <p>56 consecutive adults who presented to Respiratory Medicine Department at a tertiary care hospital in South India from November 2018 to June 2020, having Clinico-radiological suspicion of malignancy and fulfilling study criteria were recruited. They were subjected to CECT of thorax and bronchoscopy. All bronchoscopic procedures were performed using a protocolized number of passes for biopsy. The baseline demographic and clinical data, findings of bronchoscopy and CT and biopsy reports were recorded. Cohens kappa coefficient was used to estimate the agreement of findings on the two modalities. Statistical analysis was performed using SPSS software.</p> <p>Results</p> <p>Bronchoscopy was normal in 22.14 % of cases, the corresponding CTs also revealed normal airway. Bronchoscopy revealed airway lesions in 78.6 % cases; the corresponding CT revealed airway abnormalities in only 46.41 % of cases, among these 52.1 % of cases revealed an exophytic growth. There was fair strength of agreement for the two modalities in the detection of airway lesions of lung cancer. [k= 0.38, p = <0.001]. CECT thorax has a negative predictive value of 44 %, a sensitivity of 59.1 % and specificity of 100 % at 95 % CI in the detection of airway lesions.</p> <p>Conclusion</p> <p>CT is not definitive in the evaluation of lung cancer, especially in those with central disease. Combination of the two modalities improves the diagnostic outcome in patients with lung cancer.</p> <p>Keywords- Thoracic Oncology, Bronchogenic Carcinoma, Adenocarcinoma of lung, Bronchoscopy, Diagnostic Imaging, Multidetector Computed Tomography.</p>

closedIPD-NOFeb 2026View details →

Hydrops: Diagnosing & Redefining Outcomes With Precision Study

ClinicalTrials.gov study NCT03412760. IPD Sharing: NO. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

Pectus ESC Outcomes and Comparative Effectiveness Study

ClinicalTrials.gov study NCT05063695. IPD Sharing: NO. Countries: 1. Publications: 5.

restrictedIPD-UNDECIDEDFeb 2026View details →

SAFE or SORRY? Patient Safety Study of the Prevention of Adverse Patient Outcomes

ClinicalTrials.gov study NCT00365430. IPD Sharing: Not stated. Countries: 1. Publications: 3.