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170
datasets available to search
ShareScore release 0.9.0
Dataset results
170 results for “phenotypic change”
Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells (RNA-Seq)
GEO Series GSE174358. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Saracatinib inhibits TGF-β–induced phenotypic changes in human lung fibroblasts
GEO Series GSE178518. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic changes in cortical astrocytes translatome across the estrous cycle
GEO Series GSE312761. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes
GEO Series GSE288965. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Single -Cell RNA Sequencing of the Normal Human Ascending Aortic Tissues from Donors of Different Ages Reveals Significant Age-dependent Changes in the Cellular Composition, Cellular Phenotypes, and C
GEO Series GSE216860. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications"
<p>This record contains raw data related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications"</p> <p>AIMS:</p> <p>Nodule-in-nodule (N/N) hepatocellular carcinoma (HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer, more differentiated, tumour, which can be rapidly taken over by the former so that N/N HCC is rarely detected.</p> <p>METHODS AND RESULTS:</p> <p>Ten resected N/N HCCs arising in cirrhotic background and characterized: (i) as outer lesions by early (n = 3) and G1 (n = 7) HCC; (ii) as inner lesions by G1 (n = 3) and G2 (n = 7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 mm and 16/4 mm. We investigated vascular (CD34 and endocan), hepatocellular VEGF, GS, GPC3, HSP70 and CHC) and molecular (TERT promoter and β-catenin) changes taking place from the outer neoplastic compartment to the inner neoplastic compartment (INC). A diffuse pattern of CD34+ capillarized vessels and focal endocan immunoreactivity were major distinctive features acquired in the INC; VEGF immunoreactivity was inversely related to CD34 staining. A gain in the number of cells immunoreactive for GPC3, HSP70, and CHC, but not of GS-immunoreactive cells, also occurred in the INC. TERT promoter mutations were seen in half of the cases in both compartments, whereas β-catenin mutations were more rarely detectable.</p> <p>CONCLUSIONS:</p> <p>Major phenotypic changes take place in the INC of N/N HCC. TERT promoter mutations take place frequently and very early, and, in contrast to β-catenin mutations, do not appear to be acquired during N/N growth. These findings suggest that inner nodules represent a step further along the pathway of tumour progression, in contrast to earlier, simply initiated, lesions, and that complete neovascularisation predicts a change in HCC biology.</p>
Oncogenic mutation BRAF V600E changes phenotypic behavior of THLE-2 liver cells through alteration of gene expression
GEO Series GSE194425. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The short-acting GABA (A) receptor agonist remimazolam is an inhibitor of T cell activation and can induce phenotype change of regulatory T cells
GEO Series GSE236350. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages
GEO Series GSE52292. Homo sapiens. 16 samples. Type: Expression profiling by array.
Regularity of Chondrocyte Phenotypic Changes Identified by Single-cell Sequencing in vitro
GEO Series GSE270642. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.