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178
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ShareScore release 0.9.0
Dataset results
178 results for “platelet function”
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
ClinicalTrials.gov study NCT05742763. IPD Sharing: NO. Countries: 1. Publications: 0.
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
ClinicalTrials.gov study NCT05985447. IPD Sharing: NO. Countries: 1. Publications: 0.
Location and function of TDP-43 in platelets: Alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols
GEO Series GSE245303. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial gene expression is required for platelet function and blood clotting
GEO Series GSE206543. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
Exploring modulation in Staphylococcus aureus biofilm formation and virulence during platelet storage and its impact on platelet functionality
GEO Series GSE241582. Staphylococcus aureus. 12 samples. Type: Expression profiling by high throughput sequencing.
Aspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events (outpatient cardiology)
GEO Series GSE38511. Homo sapiens. 26 samples. Type: Expression profiling by array.
Platelet Function in Patients Undergoing PCI
ClinicalTrials.gov study NCT01267708. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
ClinicalTrials.gov study NCT05654766. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of Steady State Tipranavir/Ritonavir or Darunavir/Ritonavir or Ritonavir on Platelet Function, Coagulation and Fibrinolysis Biomarkers in Healthy Subjects
ClinicalTrials.gov study NCT02251795. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Platelet Function With Various Storage Techniques
ClinicalTrials.gov study NCT03338660. IPD Sharing: NO. Countries: 0. Publications: 0.
Aliskiren's Effect on Arterial Stiffness and Platelet Function in Patients With Diabetes Mellitus (DM)
ClinicalTrials.gov study NCT00732407. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Shared roles for Scl and Lyl1 in murine platelet production and function
GEO Series GSE125025. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Proteasome Function is Required for Platelet Production
GEO Series GSE58202. Homo sapiens; Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Efficient Chemical Reprogramming of Human T Cells into Functional Megakaryocytes and Platelets
GEO Series GSE310060. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
ATAXIN2 is crucial for megakaryocyte protein homeostasis and proper platelet functionality
GEO Series GSE63297. Homo sapiens. 10 samples. Type: Expression profiling by array.
Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both?
<p>Dataset from the article Ranucci M, Di Dedda U, Baryshnikova E. Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both? Platelets. 2020;31(1):88-93. doi: 10.1080/09537104.2019.1581920. Epub 2019 Mar 4. PMID: 30831043.</p> <p>Abstract</p> <p>In thromboelastometry (ROTEM<sup>TM</sup>) the difference in amplitude between the EXTEM and the FIBTEM is considered an index of platelet contribution to clot strength (PCS<sub>amp</sub>). The difference in elasticity (PCS<sub>el</sub>) is rarely used. We investigated the ability of PCS<sub>amp</sub> and PCS<sub>el</sub> in reflecting platelet count and function in 103 patients undergoing cardiac surgery, simultaneously measuring ROTEM and platelet function tests (multiple electrode aggregometry ADPtest and TRAPtest, Multiplate<sup>TM</sup>). PCS<sub>amp</sub> and PCS<sub>el</sub> were tested for association with platelet count and function. The PCS<sub>amp</sub> showed a low (R coefficient 0.32-0.39) association with platelet count and function (ADPtest), whereas the PCS<sub>el</sub> showed higher values of association (R coefficient 0.55-0.71) with the same variables. No association was found between PCS and TRAPtest. In a multivariable model, both the platelet count (R coefficient 0.60, P = 0.001) and the ADPtest (R coefficient 0.36, P = 0.001) were independently associated with the PCS<sub>el</sub>. The discrimination properties of the PCS<sub>el</sub> for the prediction of a low platelet count/function were very good (c-statistics 0.837). In clinical practice, the difference in elasticity between EXTEM and FIBTEM should replace the difference in amplitude.</p>
Dataset related to the article: "N-acetylcysteine inhibits platelet function through the regeneration of the non-oxidative form of albumin"
<p>This record contains raw data related to the article: "N-acetylcysteine inhibits platelet function through the regeneration of the non-oxidative form of albumin"</p> <p><strong>Abstract: </strong>N-acetylcysteine (NAC), is able to break down protein disulfides generating free thiols. This mechanism occurs on mixed disulfides of albumin (HSA) to form mercaptoalbumin (HMA), the main antioxidant species in the plasma. Circulating HSA exists in two main forms: the reduced form (HMA), and the oxidized forms, whose predominant modification is cystenylation (HSA-Cys). Increased levels of oxidized HSA were detected in several diseases associated with oxidative stress. This study showed that NAC inhibits platelet aggregation by restoring HMA. In addition, the regeneration of HMA by NAC inhibits platelet functions, such as intracellular calcium mobilization, reactive oxygen species generation, arachidonic acid metabolites synthesis, and adhesion to the collagen matrix. In our conditions, the exposure of platelet to NAC did not increased GSH levels. However, the inhibition of platelet aggregation was also detected following treatment of platelet-rich plasma with GSH, which, similarly to NAC, reduced HSA-Cys levels. Furthermore, this study shows that cysteine, another compound able to restore HMA by reducing the HSA-Cys content, inhibited platelet aggregation to a similar extent as NAC. The results obtained in this study suggest a new mechanism by which NAC can modulate platelet activation and suggest its possible use as an antiplatelet drug in conditions associated with oxidative stress.</p>
Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.
<p>Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.</p> <p>This is the article:</p> <p><strong>Background: </strong> Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT).</p> <p><strong>Methods: </strong> The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors.</p> <p><strong>Results: </strong> Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29).</p> <p><strong>Conclusions: </strong> Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.