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293
datasets available to search
ShareScore release 0.9.0
Dataset results
293 results for “protein kinase”
Profiling hepatic microRNAs in zebrafish: Fluoxetine exposure mimics a fasting response that targets AMP-activated protein kinase (AMPK)
GEO Series GSE55229. Danio rerio. 16 samples. Type: Non-coding RNA profiling by array.
Blockade of oncogenic IkappaB kinase activity in ABC DLBCL by small molecule BET protein inhibitors
GEO Series GSE58791. Homo sapiens. 12 samples. Type: Expression profiling by array.
Targeting DNA topoisomerases or checkpoint kinases forces a shift in global protein homeostasis, triggering widespread protein aggregation
GEO Series GSE173940. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Kinases in motion: impact of protein and small molecule interactions on kinase conformations
<p><span>Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease associated kinases using the high sensitivity of the Kinase Conformation (KinCon)reporter system. We first tracked BRAF kinase activity conformation changes upon melanoma drug binding. Second, we also use the KinCon reporter technology to examine the impact of regulatory protein interactions on LKB1kinase tumor suppressor functions. Third, we explore the conformational dynamics of RIP kinases in response to TNF pathway activation and small molecule interactions. Finally, we show that CDK4/6 interactions with regulatory proteins alter conformations which remain unaffected in the presence of clinically applied inhibitors. Apart from its predictive value, the KinCon technology helps identify cellular factors that impact drug efficacies. The understanding of the dynamics of full-length protein kinases when interacting with small molecule inhibitors or regulatory proteins is crucial for designing more effective therapeutic strategies.</span></p>
Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway
ClinicalTrials.gov study NCT06287463. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Protein Tyrosine Kinases (PTK) in Multiple Myeloma
ClinicalTrials.gov study NCT00165347. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hepatotoxicity Related to Protein Kinase Inhibitors
ClinicalTrials.gov study NCT05430126. IPD Sharing: NO. Countries: 1. Publications: 0.
Expression of AMP-activated Protein Kinase (AMPK) Protein in Lung Adenocarcinoma
ClinicalTrials.gov study NCT01249066. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Protein Tyrosine Kinase 7 (PTK7) in Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT04018183. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing,
ClinicalTrials.gov study NCT05557045. IPD Sharing: NO. Countries: 1. Publications: 0.
Isoprostane/FMD Study The Effect of Protein Kinase C (PKC) β Specific Inhibitor LY333531 on Oxidant Stress in Patients With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT00552227. IPD Sharing: Not stated. Countries: 1. Publications: 0.
P38 Mitogen-activated Protein (Map) Kinase Inhibitor (SB-681323)Study In Patients With Neuropathic Pain
ClinicalTrials.gov study NCT00390845. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT01402440. IPD Sharing: Not stated. Countries: 10. Publications: 0.
Protein Kinase N1 Level in Patients Undergoing Cardiac Surgery
ClinicalTrials.gov study NCT05386940. IPD Sharing: NO. Countries: 1. Publications: 0.
Measuring G Protein-coupled Receptor Kinase-2 (GRK2) in the Blood to Diagnose and Treat Patients With Heart Failure
ClinicalTrials.gov study NCT00419965. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prediction of Response to Kinase Inhibitors Based on Protein Phosphorylation Profiles in Tumor Tissue From Advanced Renal Cell Cancer Patients
ClinicalTrials.gov study NCT02071719. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Topical Mitogenic-Activated Protein Kinase (MAPK) Inhibition in Rosacea
ClinicalTrials.gov study NCT05616923. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of a Promising New Combination of Protein Kinase Inhibitors on Organotypic Cultures of Human Renal Tumors
ClinicalTrials.gov study NCT03571438. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Protein Kinase 2 (HIPK2) Polymorphisms on rs2058265, rs6464214, and rs7456421
ClinicalTrials.gov study NCT04804436. IPD Sharing: NO. Countries: 1. Publications: 0.
The Safety and Efficacy Evaluation of XSLJZ in Advanced Hepatocellular Carcinoma Patients With Multiple Protein Kinase Inhibitor Therapy: A Randomized, Double-Blind, Controlled Trial
ClinicalTrials.gov study NCT04562428. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.