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ShareScore release 0.9.0
Dataset results
408 results for “ubiquitin”
Identification of Factors Required for m6A mRNA Methylation in Arabidopsis Reveals a Role for the Conserved E3 Ubiquitin Ligase HAKAI
GEO Series GSE97174. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
The Ubiquitin Ligase Siah2 Regulates Obesity-induced Adipose Tissue Inflammation
GEO Series GSE61839. Mus musculus. 12 samples. Type: Expression profiling by array.
Genes related to emphysema are enriched for ubiquitination pathways
GEO Series GSE63073. Homo sapiens. 42 samples. Type: Expression profiling by array.
Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development
GEO Series GSE92751. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes
GEO Series GSE144298. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation [dataset 2]
GEO Series GSE163387. Homo sapiens; Mus musculus. 28 samples. Type: Non-coding RNA profiling by high throughput sequencing.
SUMO-targeted ubiquitin ligases (STUbLs) reduce the toxicity and abnormal transcriptional activity associated with a mutant, aggregation-prone fragment of huntingtin
GEO Series GSE115990. Saccharomyces cerevisiae. 11 samples. Type: Expression profiling by high throughput sequencing.
TRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
GEO Series GSE48196. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by genome tiling array.
TRIM33 is an oncogenic transcriptional coactivator stabilizing AR from Skp2-mediated ubiquitin-proteasomal degradation in prostate cancer [ChIP-seq]
GEO Series GSE174109. Homo sapiens. 11 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
GEO Series GSE148263. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase best known for suppression of antigen presentation by dendritic and B cells. MARCH1 was recently found to negatively regulate the cell surface levels of the insulin receptor via ubiquitination. This, in turn, impaired insulin sensitivity in mouse models. Here, we report that MARCH1-deficient (knockout; KO) female mice exhibit excessive weight gain and excessive visceral adiposity when reared on standard chow diet, without increased inflammatory cell infiltration of adipose tissue. By contrast, male MARCH1 KO mice had similar weight gain and visceral adiposity to wildtype (WT) male mice. MARCH1 KO mice of both sexes were more glucose tolerant than WT mice. The levels of insulin receptor were generally higher in insulin-responsive tissues (especially the liver) from female MARCH1 KO mice compared to males, with the potential to account in part for the differences between male and female MARCH1 KO mice. We also explored a potential role for MARCH1 in human type 2 diabetes risk through genetic association testing in publicly-available datasets, and found evidence suggestive of association. Collectively, our data indicate an additional link between immune function and diabetes, specifically implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance, whose function is modified by sex-specific factors.
Data from: Functional diversity and structural disorder in the human ubiquitination pathway
The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several hundred E3 (ubiquitin ligase) enzymes. By collecting and analyzing E3 sequences from the KEGG BRITE database and literature, we assembled a coherent dataset of 563 human E3s and analyzed their various physical features. We found an increase in structural disorder of the system with multiple disorder predictors (IUPred – E1: 5.97%, E2: 17.74%, E3: 20.03%). E3s that can bind E2 and substrate simultaneously (single subunit E3, ssE3) have significantly higher disorder (22.98%) than E3s in which E2 binding (multi RING-finger, mRF, 0.62%), scaffolding (6.01%) and substrate binding (adaptor/substrate recognition subunits, 17.33%) functions are separated. In ssE3s, the disorder was localized in the substrate/adaptor binding domains, whereas the E2-binding RING/HECT-domains were structured. To demonstrate the involvement of disorder in E3 function, we applied normal modes and molecular dynamics analyses to show how a disordered and highly flexible linker in human CBL (an E3 that acts as a regulator of several tyrosine kinase-mediated signalling pathways) facilitates long-range conformational changes bringing substrate and E2-binding domains towards each other and thus assisting in ubiquitin transfer. E3s with multiple interaction partners (as evidenced by data in STRING) also possess elevated levels of disorder (hubs, 22.90% vs. non-hubs, 18.36%). Furthermore, a search in PDB uncovered 21 distinct human E3 interactions, in 7 of which the disordered region of E3s undergoes induced folding (or mutual induced folding) in the presence of the partner. In conclusion, our data highlights the primary role of structural disorder in the functions of E3 ligases that manifests itself in the substrate/adaptor binding functions as well as the mechanism of ubiquitin transfer by long-range conformational transitions.
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin
ClinicalTrials.gov study NCT02256241. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis
ClinicalTrials.gov study NCT00819442. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
ClinicalTrials.gov study NCT05885529. IPD Sharing: NO. Countries: 2. Publications: 0.
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
GEO Series GSE247623. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Ubiquitin-activating enzyme mediates immune escape via suppressing interferon signaling
GEO Series GSE253880. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Rhamnogalacturonan Lyase 1 (RGL1), as a suppressor of E3 ubiquitin ligase Arabidopsis thaliana Ring Zinc Finger 1 (AtRZF1), is involved in dehydration response to mediate proline synthesis and pectin
GEO Series GSE266158. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing.
Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication – transcription conflicts
GEO Series GSE201158. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
GEO Series GSE43725. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.