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3,361 results for “Randomized Controlled Trial”
Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial
GEO Series GSE87186. Homo sapiens. 119 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Profile of Breast Tissue of Premenopausal Women Following Treatment with Progesterone Receptor Modulator: Secondary Outcomes of a Randomized Controlled Trial
GEO Series GSE252145. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Which are the most sensitive search filters to identify randomized controlled trials in MEDLINE?
<p>The raw data is attached for the paper: </p> <p>Which are the most sensitive search filters to identify randomized controlled trials in MEDLINE?</p>
High flow nasal oxygen during procedural sedation: A randomized controlled trial
<p>Data and code for publication</p>
Acute sleep hygiene strategy improves objective sleep latency following a late-evening soccer-specific training session: A randomized controlled trial
<p>The aim of this study was to evaluate the effects of sleep hygiene (SH) education on sleep quality in soccer players after a late-evening small-sided-game (SSG) training session. Twenty-nine non-professional players were recruited and allocated to either an experimental group (EG, n=17) that received SH education, or a control group (CG, n=12). SSG consisted of 3´4 minutes in a 4vs4, with 3 minutes of recovery and was performed at 8.00 p.m. Sleep quality was monitored via actigraphy and sleep diary entries before (PRE) and two nights after (POST1, POST2) the SSG. Sleep latency (SL) differed between the two groups at POST1 (4.9±5.4 vs. 15.5±16.1 for EG and CG, respectively; p=0.017, effect size [ES]=2.0); SL values were lower at POST1 compared to PRE for the EG (-47%; p=0.021, ES=0.6). Subjective sleep quality was better in the EG than the CG at POST1 (8.6±1.0 vs. 7.1±2.0 for EG and CG, respectively; p=0.016, ES=0.9) with a significant improvement over PRE values (+11.0%, p=0.004, ES=0.8). Despite SL and subjective sleep quality were similar in PRE and POST2, no significant deterioration in such sleep indices over time was observed for EG. No other objective sleep indices were influenced by late-evening training or SH practices implemented by the EG. Soccer players may benefit from acute SH strategies to reduce the time to sleep onset after late-evening training sessions.</p>
The effect of piezocision vs no piezocision on maxillary extraction space closure: a split-mouth, randomized controlled clinical trial.
<p>This is a “2-arm-parallel”, split-mouth trial with the aim to investigate the effects of piezocision compared to no piezocision on maxillary canine distalization and to evaluate patients’ perceptions on the surgical procedure.</p>
Data from: Video education versus face-to-face education on inhaler technique for patients with well-controlled or partly-controlled asthma: a phase IV, open-label, non-inferiority, multicenter, randomized, controlled trial
Background: Education on inhaler technique is critical for effective asthma treatment. However, traditionally used face-to-face education is a time-consuming, costly, and often laborious. The current study evaluated the efficacy of a newly developed video-based inhaler technique education method. Methods: A total of 184 subjects with well-controlled or partly-controlled asthma were enrolled from 12 hospitals in South Korea from 30 November 2015 to 01 June 2016. Subjects were randomly divided into two groups in a 1:1 ratio; a control group that received face-to-face education, and an study group that received video education. All subjects received fluticasone propionate plus salmeterol xinafoate (Fluterol® 250/50 inhalation capsules) for 12 weeks. The primary outcome measure was forced expiratory volume in the 1st second (FEV1) at 12 weeks. The secondary outcome measures were change in FEV1 at 4 weeks, change in asthma control test (ACT) score, and changes in various inhaler technique parameters. These measures were assessed with a non-inferiority margin of 10% between the control group and the study group. Results: FEV1 was significantly improved at 12 weeks in the control group and the study group. After adjustment, FEV1 improvement was not significantly inferior in the study group compared to the control group. The secondary outcome measures, including change in FEV1 at 4 weeks, ACT score, and various parameters pertaining to inhaler technique and satisfaction at 4 and 12 weeks did differ not significantly in the two groups. In subgroup analysis of elderly subjects and subjects with well-controlled asthma, FEV1 was significantly improved at 12 weeks in the study group but not the control group. Conclusion: The newly developed video education technique investigated functioned as a suitable substitute for face-to-face education on inhaler technique (dry powder inhalation capsule) in patients with stable asthma, particularly in elderly patients and patients with well-controlled asthma.
Clinical usability study of a transcranial direct current stimulation for primary dysmenorrhea: a randomized controlled trial
Open the record for dataset details and reuse information.
Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases
<p>Supplementary Dataset 1. Select ClinicalTrials.Gov data fields for the RCT studies identified as the main dataset.<br> Supplementary Dataset 2. Select ClinicalTrials.Gov data fields for the RCT studies identified as the literature dataset.<br> Supplementary Dataset 3. Comparison of frequency of RCT general features between the Main dataset and background of all RCTs available in ClinicalTrials.Gov.<br> Supplementary Dataset 4. Case series of MR and RCT studies with matching exposures (interventions) and outcomes (conditions).</p>
[DATABASE] Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial
<p><strong>Background: </strong>People who smoke and who face challenges trying to quit or wish to continue to smoke may benefit by switching from traditional cigarettes to noncombustible nicotine delivery alternatives, such as heated tobacco products (HTPs) and electronic cigarettes (ECs). HTPs and ECs are being increasingly used to quit smoking, but there are limited data about their effectiveness.</p> <p><strong>Objective: </strong>We conducted the first randomized controlled trial comparing quit rates between HTPs and ECs among people who smoke and do not intend to quit.</p> <p><strong>Methods: </strong>We conducted a 12-week randomized noninferiority switching trial to compare effectiveness, tolerability, and product satisfaction between HTPs (IQOS 2.4 Plus) and refillable ECs (JustFog Q16) among people who do not intend to quit. The cessation intervention included motivational counseling. The primary endpoint of the study was the carbon monoxide-confirmed continuous abstinence rate from week 4 to week 12 (CAR weeks 4-12). The secondary endpoints included the continuous self-reported ≥50% reduction in cigarette consumption rate (continuous reduction rate) from week 4 to week 12 (CRR weeks 4-12) and 7-day point prevalence of smoking abstinence.</p> <p><strong>Results: </strong>A total of 211 participants completed the study. High quit rates (CAR weeks 4-12) of 39.1% (43/110) and 30.8% (33/107) were observed for IQOS-HTP and JustFog-EC, respectively. The between-group difference for the CAR weeks 4-12 was not significant (P=.20). The CRR weeks 4-12 values for IQOS-HTP and JustFog-EC were 46.4% (51/110) and 39.3% (42/107), respectively, and the between-group difference was not significant (P=.24). At week 12, the 7-day point prevalence of smoking abstinence values for IQOS-HTP and JustFog-EC were 54.5% (60/110) and 41.1% (44/107), respectively. The most frequent adverse events were cough and reduced physical fitness. Both study products elicited a moderately pleasant user experience, and the between-group difference was not significant. A clinically relevant improvement in exercise tolerance was observed after switching to the combustion-free products under investigation. Risk perception for conventional cigarettes was consistently higher than that for the combustion-free study products under investigation.</p> <p><strong>Conclusions: </strong>Switching to HTPs elicited a marked reduction in cigarette consumption among people who smoke and do not intend to quit, which was comparable to refillable ECs. User experience and risk perception were similar between the HTPs and ECs under investigation. HTPs may be a useful addition to the arsenal of reduced-risk alternatives for tobacco cigarettes and may contribute to smoking cessation. However, longer follow-up studies are required to confirm significant and prolonged abstinence from smoking and to determine whether our results can be generalized outside smoking cessation services offering high levels of support.</p>
Endothelial Cell Loss in Pseudophakic Patients Receiving a Paul Glaucoma Drainage Device With Its Tube Inserted in the Anterior Versus Posterior Chamber: a Randomized Controlled Trial
ClinicalTrials.gov study NCT05500469. IPD Sharing: NO. Countries: 1. Publications: 0.
HUMAN CHORIONIC GONADOTROPIN (HcG) VS MAGNESIUM SULPHATE (MgSo4) AS A TOCOLYTIC AGENT- A RANDOMIZED CONTROLLED TRIAL
ClinicalTrials.gov study NCT05828966. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Pilot Randomized Controlled Trial of Chatbot Use in Older Adults for Lifestyle Change
ClinicalTrials.gov study NCT06901037. IPD Sharing: NO. Countries: 1. Publications: 0.
A Randomized, Double-blind, Multi-center, Active-controlled, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy of THP-00101, THP-00102, and THP-00103 in Subjects With T
ClinicalTrials.gov study NCT06647745. IPD Sharing: UNDECIDED. Countries: 2. Publications: 0.
Comparing Approaches to Treat Older Adult Women's Urge Incontinence: Pilot Feasibility and Randomized Controlled Trial
ClinicalTrials.gov study NCT03176901. IPD Sharing: NO. Countries: 1. Publications: 0.
Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)
ClinicalTrials.gov study NCT06854614. IPD Sharing: NO. Countries: 1. Publications: 0.
A Randomized, Double-blinded, Active Controlled Crossover Clinical Trial to Investigate PK, PD and Safety of GBPD002
ClinicalTrials.gov study NCT05585658. IPD Sharing: NO. Countries: 1. Publications: 0.
Ultrasound Guided Needling Versus Ultrasound Guided Corticosteroid Injection Alone, a Randomized Controlled Trial.
ClinicalTrials.gov study NCT01538758. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Control Trial of an Animal-Assisted Intervention With Adjudicated Youth
ClinicalTrials.gov study NCT01594606. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Oral Isosorbide Mononitrate Therapy on Umbilical Artery Doppler Resistance Index in Pregnancies With Intrauterine Growth Restriction: Prospective Randomized Control Trial
ClinicalTrials.gov study NCT05800938. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.