Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,985
datasets available to search
ShareScore release 0.9.0
Dataset results
1,985 results for “Antigen”
MD Simulation Carcinoma Antigen [Replicates-Data]
<p><strong>MD-simulation data files </strong><br><strong>ACC1:</strong> Saquamous cell carcinoma antigen [replicate 1]<br><strong>ACC2:</strong> Saquamous cell carcinoma antigen [replicate 2]<br><strong>HMGB1:</strong> Hemoglobin [replicate 1]<br><strong>HMGB2:</strong> Hemoglobin [replicate 2]<br><strong>PSA1:</strong> Prostate specific antigen [replicate 1]<br><strong>PSA2:</strong> Prostate specific antigen [replicate 2]</p> <p><strong>RMSD:</strong> Root mean square deviation<br><strong>RMSF:</strong> Root mean square fluctuation</p>
Dataset related to article "Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease "
<p>This record contains raw data related to article "Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease "</p> <p><strong>Introduction: </strong> Antimitochondrial antibodies (AMAs) are the hallmark of primary biliary cholangitis (PBC) but can be identified also in patients with connective tissue disease, namely, systemic sclerosis (SSc). Protein immunoprecipitation (IP) and IP-Western blot (WB) can be used to confirm AMA positivity directed at the pyruvate dehydrogenase complex (PDC) subunits E1α, E1β, E2/E3, and E3BP in patients showing a cytoplasmic reticular pattern at indirect immunofluorescence when performed in a screening setting before the onset of overt cholestasis in rheumatic patients.</p> <p><strong>Patients and methods: </strong> We studied sera from 285 patients affected by connective tissue disease [SSc, n = 144; dermato/polymyositis (DM/PM), n = 56; and undifferentiated connective tissue disease (UCTD), n = 85] by indirect immunofluorescence (IIF), protein-IP, and IP-WB to identify specific PDC subunits recognized by AMA.</p> <p><strong>Results: </strong> Twenty percent (57/285) of sera from patients with connective tissue disease had a cytoplasmic reticular pattern at IIF, and in 77% (44/57, including 20 SSc, 12 PM/DM, and 12 UCTD) of these, we detected different titers of autoantibodies against the PDC subunits, specifically against PDC-E2. Among these sera, 4 (9%) tested positive for anti-E1α, 15 (34%) for anti-E1β, and 16 (36%) for anti-E3BP. Four of the 20 AMA-positive SSc cases (20%) had been already diagnosed with PBC, and all were positive for autoantibodies against the subunits PDC-E2, E3, and E3BP.</p> <p><strong>Conclusions: </strong> Using IIF and IP, we confirm that autoantibodies against the PDC components are detected in rheumatic patients with PBC or without liver dysfunction. In view of the strong predictive value of AMA for PBC, a strict follow-up of these latter patients is warranted for an early diagnosis of the disease</p>
Individual Patient Investigational New Drug (IND) Expanded Access Program of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy for Participant With Multiple Myeloma
ClinicalTrials.gov study NCT04452994. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Preclinical model of anti-PDL1 Immune-checkpoint blockade (ICB) resistance in breast cancer associated to low antigen presentation machinery (APM)
GEO Series GSE176580. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Dual-antigen Doggybone DNA vaccine induces potent anti-tumour immunity against immunosuppressive oral cancer
GEO Series GSE310571. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
CD19 Chimeric Antigen Receptor Engineered NK92 Natural Killer Cells: Novel “Off the Shelf” Immunotherapy in Non-Hodgkin Lymphoma II
GEO Series GSE120316. Homo sapiens. 24 samples. Type: Expression profiling by array.
Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation [TCR-seq]
GEO Series GSE154604. Mus musculus. 12 samples. Type: Other.
Mal2 drives immune evasion by reducing antigen presentation on tumor cells
GEO Series GSE144099. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Antigen-reactive CD4 T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation [separate samples]
GEO Series GSE310441. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens
GEO Series GSE181046. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Anti-Interleukin-10 unleashes transcriptional response to leishmanial antigen in whole blood of visceral leishmaniasis patients
GEO Series GSE146908. Homo sapiens. 44 samples. Type: Expression profiling by array.
Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins
GEO Series GSE67666. Measles morbillivirus. 3 samples. Type: Other.
Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation
GEO Series GSE171158. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Induction of anergy in human T lymphocytes by exposure to single amino acid mutated antigens is stochastic
GEO Series GSE295405. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
IRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development [expression array]
GEO Series GSE64269. Homo sapiens. 2 samples. Type: Expression profiling by array.
Local antigen is required for CD8+ tissue resident memory T cell (Trm) generation in large intestine
GEO Series GSE230515. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Gene expression signatures after immunisation with an HIV-1 recombinant Vesicular Stomatitis Virus (VSV) vaccine following three priming doses of IL-12 pDNA enhanced HIV-1 multi-antigen pDNA vaccine
GEO Series GSE125019. Homo sapiens. 108 samples. Type: Expression profiling by array.
Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression
GEO Series GSE118822. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors
GEO Series GSE252247. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of T cell fraction enriched for donor antigen-reactive T cells in skin allografted recipient mice (I)
GEO Series GSE32952. Mus musculus. 8 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.