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4,004 results for “In vivo”
Raw MRI imaging for "In Vivo Neuroprotection in Ischemic Stroke by Activated Protein C Requires β-Arrestin 2"
<p><span>The protease, activated protein C (APC) and its variants provide pharmacological benefits in many murine preclinical injury models, including neuroprotection for ischemic stroke and mortality reduction for sepsis.<span> </span>The <em>in vivo</em> mechanism of action for APC in ischemic stroke and sepsis injury models, similar to extensive in vitro studies using cultured cells, involves protease activated receptor (PAR) 1-mediated biased signaling. Cell culture studies showed that APC/PAR1 signaling requires β-Arrestin 2, an intracellular scaffold protein, and that β-Arrestin 2-dependent, APC-initiated signaling can distinctly alter a wide variety of intracellular signaling pathways.<span> </span>It is unclear whether <em>in vitro</em> studies can be extrapolated to <em>in vivo</em> mechanisms of action.<span> </span>This study employed a proximal transient Middle Cerebral Artery Occlusion model to study the neuroprotective actions of the signaling-selective APC variant, 3K3A-APC, in β-arrestin 2 deficient (<em>Arrb2</em><sup>-/-</sup>) mice. Based on the size and shape of brain injury areas, 3K3A-APC significantly limited brain injury in control mice to a relatively small, localized area whereas these protective effects were lost in <em>Arrb2<sup>-/-</sup></em> mice. Thus, these data indicate that the major <em>in vitro</em> mechanism of action that requires β-arrestin 2 for APC/PAR1 biased signaling is central to the <em>in vivo</em> mechanism of action for APC’s neuroprotection. </span></p>
The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo
<p>Molecular Discovery for Optic Nerve Regeneration (Goldberg, Benowitz and Cline labs):</p> <p>The aim of this project is to identify genes and proteins that promote or inhibit the ability of retinal ganalion cells to regenerate axons and form functional synaptic connections. This work has been published in the following manuscript.</p> <p>This study characterizes axonally transported proteins in the healthy adult visual system by analyzing proteomes from multiple compartments of retinal ganglion cell projections in the intact brain.</p> <p>See the following visualizations to explore the findings:</p> <ul> <li><a href="https://viz.stjude.cloud/stjude/visualization/transcriptional-profiling-of-retinal-ganglion-cells-during-optic-nerve-regeneration-in-adult-and-embryonic-and-post-natal-development~54">Transcriptional profiling of RGCs during optic nerve regeneration</a></li> </ul>
Self-propagating wave drives noncanonical antidurotaxis of skull bones in vivo
<p>Cell motility is a key feature of tissue morphogenesis, and it is thought to be driven primarily by the active migration of individual cells or collectives. However, this model is unlikely to apply to cells lacking overt cytoskeletal, stable cell-cell or cell-cell adhesions, and molecular polarity, such as mesenchymal cells. Here, by combining a novel imaging pipeline with biophysical modeling, we discover that during skull morphogenesis, a self-generated collagen gradient expands a population of osteoblasts towards a softer matrix. Biomechanical measurements revealed a gradient of stiffness and collagen along which cells move and divide. The moving cells generate an osteogenic front that travels faster than individual tracked cells, indicating that expansion is also driven by cell differentiation. Through biophysical modeling and perturbation experiments, we found that mechanical feedback between stiffness and cell fate drives bone expansion and controls bone size. Our work provides a mechanism for coordinated motion that does not rely upon the cytoskeletal dynamics of cell migration. We term this self-propagating motion down a stiffness gradient, noncanonical antidurotaxis. Identification of alternative mechanisms of cellular motion will help in understanding how directed cellular motility arises in complex environments with inhomogeneous material properties.</p>
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
ClinicalTrials.gov study NCT05518565. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Phase I In-Vivo Peptide Applied in the Right Colon
ClinicalTrials.gov study NCT01722058. IPD Sharing: Not stated. Countries: 1. Publications: 0.
In-vivo Extraction of Lead, Cadmium and Tobacco Specific Nitrosamines From Swedish 'Snus' in Regular Snus Users
ClinicalTrials.gov study NCT01838473. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autologous Peripheral Blood Stem Cell Transplantation With In Vivo Purging as an Alternate Stem Cell Transplantation Program for Pts w/AML in 1st & 2nd Complete Remission w/no HLA Matched Related Dono
ClinicalTrials.gov study NCT00531583. IPD Sharing: Not stated. Countries: 1. Publications: 0.
FAPi-PET Imaging of in Vivo Fibrosis in Inflammatory Bowel Disease Patients
ClinicalTrials.gov study NCT06604260. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung
ClinicalTrials.gov study NCT05611034. IPD Sharing: NO. Countries: 1. Publications: 0.
Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
ClinicalTrials.gov study NCT06418256. IPD Sharing: NO. Countries: 1. Publications: 0.
In Vivo Effects of the Gluten Friendly Bread in Coeliac Disease
ClinicalTrials.gov study NCT03168490. IPD Sharing: NO. Countries: 1. Publications: 0.
Cannabidiol - an in Vivo Innovative Drug Delivery Study
ClinicalTrials.gov study NCT03471559. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Using Image Standardization Device for Dental Photography Standerdizatuon in Comparison to Individualized Photography In Vivo Study
ClinicalTrials.gov study NCT04991363. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
In Vivo Damage Induced bu UV in the Epidermis of the Scalp
ClinicalTrials.gov study NCT04142489. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of the Blood and Skin Immunological Profile of Patients With Recessive Dystrophic Epidermolysis Bullosa: in Vivo Analysis and the Impact of Placental Stem Cells in Vitro
ClinicalTrials.gov study NCT06177353. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers
ClinicalTrials.gov study NCT07388901. IPD Sharing: Not stated. Countries: 1. Publications: 0.
In Vivo Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant
ClinicalTrials.gov study NCT01882751. IPD Sharing: NO. Countries: 1. Publications: 0.
In Vivo Molecular Imaging Predicts Therapeutic Response in Ulcerative Colitis
ClinicalTrials.gov study NCT02852850. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Dabigatran on Coagulation parameters-an ex Vivo Study
ClinicalTrials.gov study NCT01112202. IPD Sharing: Not stated. Countries: 1. Publications: 0.
In Vivo Cross-Modal Imaging of Skin
ClinicalTrials.gov study NCT07188948. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.