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1,981 results for “coronary artery”
Genetic variants associated with coronary artery disease in Indians
GEO Series GSE109068. Homo sapiens. 300 samples. Type: Genome variation profiling by SNP array.
Long-term secondary cardiovascular prevention programme in patients subjected to coronary artery bypass surgery
<p>This record contains raw data related to the article: Long-term secondary cardiovascular prevention programme in patients subjected to coronary artery bypass surgery</p> <p>Abstract</p> <p><strong>Aims: </strong>Patients with coronary heart disease (CHD) are at very high risk of recurrent events. A strategy to reduce excess risk might be to deliver structured secondary prevention programmes, but their efficacy has been mostly evaluated in the short term and in experimental settings. This is a retrospective case-control study aimed at assessing, in the real world, the efficacy of a secondary prevention programme in reducing long-term coronary event recurrences after coronary artery bypass surgery (CABG).</p> <p><strong>Methods and results: </strong>Programme participants (henceforth 'cases') were men and women aged <75 years subjected to CABG between 2002 and 2014, living within 100 km of the hospital. Key programme actions included optimization of treatments according to the most updated European preventive guidelines, surveillance of therapy adherence, and customized lifestyle counselling. Controls were analogous patients not involved in the programme because living farther than 100 km away, matched 1:1 with cases for gender, age at CABG, and year of CABG. Both groups (n = 1248) underwent usual periodic cardiology follow-up at our centre. Data on symptomatic or silent CHD recurrences were obtained from the hospital electronic health records. Cox analysis (adjusted for baseline differences between groups) shows that programme participation was associated with a significantly lower incidence throughout 5 years post-CABG of symptomatic [hazard ratio (95% confidence interval): 0.59 (0.38-0.94)] and silent [0.53 (0.31-0.89)] coronary recurrences.</p> <p><strong>Conclusion: </strong>In a real-world setting, taking part in a structured longstanding secondary prevention programme, in addition to usual cardiology care, meaningfully lowers the risk of coronary recurrences.</p>
PBMC classification during the evolution of Coronary Artery Disease by Single-cell RNA sequencing
<p><strong>Coronary artery disease (CAD), the leading cause of morbidity and mortality, is a pathological process driven mainly by cholesterol and inflammation, which synergically act in damaging of the coronary artery tree. While cholesterol-lowering is a cornerstone of CAD therapeutics, inflammation reduction has yet to enter into clinical practice. Understanding the variety of the immune subpopulations contributing to CAD could help identify patients who could benefit the most from anti-inflammatory therapies. The aim of the current study was therefore to determine whether specific circulating inflammatory cells are associated with different degrees of coronary artery stenosis and to possibly identify a genetic inflammatory signature associated with disease progression</strong></p>
Aminoterminal Propeptide of Type III Procollagen and Severity of Coronary Artery Disease in Patients Without Myocardial Infarction
ClinicalTrials.gov study NCT00172432. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Characterization of m6A modified RNAs in ox-LDL treated coronary artery smooth muscle cells
GEO Series GSE214719. Homo sapiens. 12 samples. Type: Other.
Exposure to 60 minutes of hyperoxia upregulates myocardial humanins in patients with coronary artery disease
GEO Series GSE66249. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions [RNA-seq]
GEO Series GSE165924. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Colocalization of GWAS and molecular QTL signals in human vascular smooth muscle cells predict candidate causal genes for coronary artery disease and vascular disorders
GEO Series GSE198544. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ABCA1-eRNA as a novel Epigenetic Regulator, promotes cholesterol efflux, Attenuates Macrophage Inflammation and Severity of Coronary Artery Disease [ATAC-seq]
GEO Series GSE192936. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Chromatin accessibility profiling of human coronary arteries identifes disease regulatory variants
GEO Series GSE188422. Homo sapiens. 35 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions
GEO Series GSE165925. Homo sapiens. 168 samples. Type: Other; Expression profiling by high throughput sequencing.
Characterization of culprit-coronary artery miRNA expression in acute myocardial infarction male patients
GEO Series GSE230165. Homo sapiens. 33 samples. Type: Non-coding RNA profiling by high throughput sequencing.
PTEN Deficiency Promotes Pathological Vascular Remodeling of Human Coronary Arteries
GEO Series GSE110622. Rattus norvegicus. 4 samples. Type: Expression profiling by array.
To evaluate the effect of Terminalia arjuna as an adjuvant therapy in subjects with stable coronary artery disease on standard dosage regimens versus placebo
GEO Series GSE56886. Homo sapiens. 8 samples. Type: Expression profiling by array.
Right ventricular failure due to coronary artery ligation
GEO Series GSE31619. Sus scrofa. 18 samples. Type: Expression profiling by array.
ABCA1-eRNA as a novel Epigenetic Regulator, promotes cholesterol efflux, Attenuates Macrophage Inflammation and Severity of Coronary Artery Disease
GEO Series GSE192940. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ABCA1-eRNA as a novel Epigenetic Regulator, promotes cholesterol efflux, Attenuates Macrophage Inflammation and Severity of Coronary Artery Disease [CUT&TAG]
GEO Series GSE192937. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
mRNA Expression data from murine hearts subjected to ligation of the left anterior descending coronary artery (myocardial infarction, MI model) or sham surgery (SH)
GEO Series GSE71906. Mus musculus. 12 samples. Type: Expression profiling by array.
DATASET RELATED TO THE ARTICLE "Interpretability of coronary CT angiography performed with a novel whole-heart coverage high-definition CT scanner in 300 consecutive patients with coronary artery bypass grafts"
<p>This record contains raw data related to the article: Interpretability of coronary CT angiography performed with a novel wholeheart</p> <p>coverage high-definition CT scanner in 300 consecutive patients with</p> <p>coronary artery bypass grafts'</p> <p>Aims: Coronary CT angiography (CCTA) is an accurate non-invasive tool for the evaluation of coronary artery</p> <p>bypass graft (CABG). However, inability to sustain a long breath-hold, high heart rate (HR) and atrial fibrillation</p> <p>may affect image quality. Moreover, radiation exposure is still a matter of some concern. A scanner combining</p> <p>0.23-mm spatial resolution, new iterative reconstruction and fast gantry rotation time has been recently introduced</p> <p>in the clinical field. The aims of our study were to evaluate interpretability, radiation exposure and</p> <p>diagnostic accuracy of CCTA performed with the latest generation of cardiac-CT scanners compared to invasive</p> <p>coronary angiography (ICA) in the assessment of bypass grafts, and non-grafted and post-anastomotic native</p> <p>coronary arteries.</p> <p>Methods and results: We prospectively enrolled 300 patients undergoing clinically indicated CCTA with a 16-cm</p> <p>z-axis coverage, 256-detector rows, and 0.28-sec gantry rotation time scanner. Coronary artery and graft interpretability,</p> <p>image quality and effective dose (ED) were assessed in all patients and diagnostic accuracy was</p> <p>evaluated in a subgroup of 100 patients who underwent ICA.</p> <p>Mean HR during the scan was 69.6 ± 10.8. Sinus rhythm was present in 118 patients with HR < 75 bpm</p> <p>and in 112 patients with HR≥75 bpm, while 70 patients had atrial fibrillation. CABG interpretability was</p> <p>100%. Compared to ICA, CCTA was able to correctly detecting occlusions or significant stenoses of all CABG</p> <p>segments. Overall interpretability of native coronary segments was 95.6%. Sensitivity, specificity, positive</p> <p>predictive value, negative predictive value and accuracy of coronary arteries were 98.3%, 97.4%, 93.1%, 99.3%</p> <p>and 96.5%, respectively. The diagnostic accuracy in a patient based analysis was 95.2%. Mean ED was</p> <p>3.14 ± 1.7 mSv.</p> <p>Conclusions: The novel whole-heart coverage CT scanner allows to evaluating CABG and native coronary arteries</p> <p>with excellent interpretability and low radiation exposure even in the presence of unfavorable heart rhythm.</p>
Data set from the article Bari V, Vaini E, Pistuddi V, Fantinato A, Cairo B, De Maria B, Dalla Vecchia LA, Ranucci M, Porta A. Comparison of Causal and Non-causal Strategies for the Assessment of Baroreflex Sensitivity in Predicting Acute Kidney Dysfunction After Coronary Artery Bypass Grafting. Front Physiol. 2019 Oct 18;10:1319. doi: 10.3389/fphys.2019.01319. PMID: 31681021; PMCID: PMC6813722.
<p>Data set from the article Bari V, Vaini E, Pistuddi V, Fantinato A, Cairo B, De Maria B, Dalla Vecchia LA, Ranucci M, Porta A. Comparison of Causal and Non-causal Strategies for the Assessment of Baroreflex Sensitivity in Predicting Acute Kidney Dysfunction After Coronary Artery Bypass Grafting. Front Physiol. 2019 Oct 18;10:1319. doi: 10.3389/fphys.2019.01319. PMID: 31681021; PMCID: PMC6813722.</p> <p>This is the abstract:</p> <p>Coronary artery bypass graft (CABG) surgery may lead to postoperative complications such as the acute kidney dysfunction (AKD), identified as any post-intervention increase of serum creatinine level. Cardiovascular control reflexes like the baroreflex can play a role in the AKD development. The aim of this study is to test whether baroreflex sensitivity (BRS) estimates derived from non-causal and causal approaches applied to spontaneous systolic arterial pressure (SAP) and heart period (HP) fluctuations can help in identifying subjects at risk of developing AKD after CABG and which BRS estimates provide the best performance. Electrocardiogram and invasive arterial pressure were acquired from 129 subjects (67 ± 10 years, 112 males) before (PRE) and after (POST) general anesthesia induction with propofol and remifentanil. Subjects were divided into AKDs (<em>n</em> = 29) or no AKDs (noAKDs, <em>n</em> = 100) according to the AKD development after CABG. The non-causal approach assesses the transfer function from the HP-SAP cross-spectrum in the low frequency (LF, 0.04-0.15 Hz) band. BRS was estimated according to three strategies: (i) sampling of the transfer function gain at the maximum of the HP-SAP squared coherence in the LF band; (ii) averaging of the transfer function gain in the LF band; (iii) sampling of the transfer function gain at the weighted central frequency of the spectral components of the SAP series dropping in the LF band. The causal approach separated the two arms of cardiovascular control (i.e., from SAP to HP and <em>vice versa</em>) and accounted for the confounding influences of respiration via system identification and modeling techniques. The causal approach provided a direct estimate of the gain from SAP to HP by observing the HP response to a simulated SAP rise from the identified model structure. Results show that BRS was significantly lower in AKDs than noAKDs during POST regardless of the strategy adopted for its computation. Moreover, all the BRS estimates during POST remained associated with AKD even after correction for demographic and clinical factors. Non-causal and causal BRS estimates exhibited similar performances. Baroreflex impairment is associated with post-CABG AKD and both non-causal and causal methods can be exploited to improve risk stratification of AKD after CABG.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.