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1,985 results for “Antigen”
Disease-specific exhaustion features and PD-1 immunotherapy responsiveness of antigen-specific CD8+ T cells at single-cell resolution [scRNA-seq]
GEO Series GSE152618. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Antigen presentation by B cells enables epitope spreading across an MHC barrier
GEO Series GSE202358. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing; Other.
Disease-specific exhaustion features and PD-1 immunotherapy responsiveness of antigen-specific CD8+ T cells at single-cell resolution
GEO Series GSE152628. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches [Xenium PM]
GEO Series GSE274623. Homo sapiens. 8 samples. Type: Other.
Gene expression data from multiple myeloma cell lines treated with Novel Anti-B-cell Maturation Antigen α-Amanitin Antibody-drug Conjugate, HDP-101.
GEO Series GSE148242. Homo sapiens. 32 samples. Type: Expression profiling by array.
Thimerosal blockades the occlusion of the antigen-binding sites of the mAb 7D3 to bind the ORF3 peptide (residues 35–65) of PCV2
<p><strong>Supplementary Materials:</strong><strong> </strong>Figure S1: Assessment of preservative affecting specific mAb-peptide N1 binding by IIDM, Figure S2: Effect of thimerosal on the binding of specific antibodies to peptide N1, Figure S3: Amino acid sequence alignments of the Pirh2 from three species of animals, data of assays or figure.</p>
Dataset related to article "p2PSA for predicting biochemical recurrence of prostate cancer earlier than total prostate-specific antigen after radical prostatectomy: an observational prospective cohort study."
<p>BACKGROUND:</p> <p>There is an unmet clinical need for more biochemical specific tests that may detect clinically significant recurrent PCa at an early stage after radical prostatectomy (RP). Our purpose is to test the hypothesis that p2PSA (Index test) detects prostate cancer relapse (BCR) earlier than the current Reference Standard Test (total prostate-specific antigen [tPSA]) in patients who underwent RP for localized PCa.</p> <p>METHODS:</p> <p>This is an observational, prospective, cohort, follow-up study in patients subjected to RALP (robotic assisted laparoscopic radical prostatectomy) for clinically localized PCa from January 2013 to July 2013 at a high-volume Institution (450 average RP/year). A blood sample, for tPSA and p2PSA, was prospectively drawn after 3, 6, and 12 months and then every 6 months during the following two years. The primary outcome is to determine whether or not kinetics in rising of p2PSA significantly anticipates the tPSA kinetics. Exploratory data analysis was used to identify relationship between different variables.</p> <p>RESULTS:</p> <p>Over 134 patients 20 BCRs were detected according to tPSA cut-off. Five patients showed a contemporary increase of tPSA and p2PSA, 11 presented a p2PSA increase earlier than tPSA increase (13.9 months ±9.7). In four patients, the increase of PSA was not associated with a p2PSA>0.8 pg/mL. The correlation between tPSA and p2PSA according to Sperman's rho coefficient was statistically significant at 3, 6, 18 and 30 months: 0.416 (P<0.01), 0.255 (P<0.01), 0.359 (P<0.01) and 0.413 (P<0.01) respectively. When subjects were stratified according to stage/grade and margins (positive vs. negative), patients with higher stage and positive surgical margins could be considered the target categories. The low rate of observed BCR and high rate of p2PSA false positive are the main limitations.</p> <p>CONCLUSIONS:</p> <p>The current findings showed that p2PSA might be more sensitive than tPSA in detecting earlier BCR within 3-year follow-up. Further studies with a longer follow-up and larger population remain mandatory before considering p2PSA for clinical decision-making.</p>
Sensitivity of serology assay in Covid-19 diagnosis: does the antigen matter?
<p>Dataset from Sitzia C, Pistelli L, Cardani R, Renna LV, Ranucci M, Carrara M, Borlini S, Clerici P, Rampoldi B, Cornetta M, Corsi-Romanelli M. Sensitivity of serology assay in Covid-19 diagnosis: does the antigen matter? J Biol Regul Homeost Agents. 2021 May-Jun;35(3):881-887. doi: 10.23812/21-163-A. PMID: 34231353.</p> <p>Abstract</p> <p>Since the spreading of Sar-CoV-2 in March 2020, many serologic tests have been developed to identify antibody responses. Indeed, different commercial kits are directed against different antigens and could utilise different methods thereby triggering confusion and criticism. Here, we compared two Food and Drug Administration (FDA)-approved automatized assays that detect IgG responses against spike or nucleocapsid protein of Sars-Cov-2 virus in 127 subjects among healthcare workers of IRCCS Policlinico San Donato (MI), Italy. We observed different kinetics of IgG responses, demonstrating the importance of timing of sampling to correctly interpret the results both for infection diagnosis and for epidemiologic studies. We observed that Anti-N response starts earlier than Anti-S1/S2 response but also decreases earlier, affecting the sensitivity of the tests at different time points. Combining two different assays, designed against different antigens, could reduce false negative results. Finally, we observed a patient who produced anti-nucleocapsid IgG, but not anti-spike IgG. In conclusion, we investigated antibody responses in Covid-19 disease, aiming to direct clinicians and laboratory scientists to correctly interpret serologic results by always paying attention to clinical history correlation, timing of sampling, methods and antigens used, to avoid false negative results and obtain relevant epidemiologic data.</p>
Evolution and modulation of antigen-specific T cell responses in melanoma patients
<p>* Unpublished TCRseq repertoire data (Helsinki cohort)<br> * Unpublished epitope-specific (MART1 AAGIGILTV) TCRseq data <br> * Unpublished TCRGP models for predicting anti-MAA T cells with TCRGP (please see https://github.com/emmijokinen/TCRGP)<br> * Published TCRseq reperotire data</p>
Reduced antigen-triggered BCR signaling in Fcmr-deficient B cells
GEO Series GSE298232. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Mycobacterial cord factor reprograms the macrophage response to IFN-gamma towards enhanced inflammation yet impaired antigen presentation and expression of Gbp1
GEO Series GSE137150. Mus musculus. 42 samples. Type: Expression profiling by array.
Tamoxifen-induced Ghr deletion in SV40 C3(1) T-antigen mouse prostates
GEO Series GSE197683. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity [RNA-seq]
GEO Series GSE228886. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Bone marrow stromal cell antigen 2 is a novel therapeutic target of glioblastoma stem cells
GEO Series GSE85024. Homo sapiens. 2 samples. Type: Expression profiling by array.
Keratinocyte-secreted SAA1 induces a population of long-lived antigen-presenting neutrophils that drives Sweet Syndrome
GEO Series GSE291004. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Role of myelin-derived antigens in pain: a female connection
GEO Series GSE107159. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
B cells targeting parasites capture spatially linked antigens to secure T cell help
GEO Series GSE274341. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA-seq identifies a distinct response in macrophages stimulated from phagosome with early secreted antigenic target 6-KDa from Mycobacterium tuberculosis
GEO Series GSE108393. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcription map of the Swine Leukocyte Antigen complex and comparative biology of MHCs among vertebrates
GEO Series GSE35828. Sus scrofa. 8 samples. Type: Expression profiling by genome tiling array.
Transgenic expression of polyoma virus middle T antigen in the mouse prostate gives rise to carcinoma
GEO Series GSE26234. Mus musculus. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.