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1,989 results for “Blood pressure”
Characterization of mouse ocular responses (intraocular pressure) to a 35-day (RR-9) spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To investigate possible mechanisms, changes in protein expression profiles were examined in mouse ocular tissue after spaceflight. Ten week old male C57BL/6 mice were launched to the International Space Station (ISS) on Space-X 12 at the Kennedy Space Center (KSC) on August, 2017. After a 35-day mission, mice were returned to Earth alive. Within 38 +/− 4 hours of splashdown, mice were euthanized and ocular tissues were collected for analysis. Ground control (GC) and vivarium control mice were maintained on Earth in flight hardware or normal vivarium cages respectively. Repeated intraocular pressure (IOP) measurements were performed before the flight launch and remeasured before the mice were euthanized after splashdown. IOP was significantly lower in post-flight measurements compared to that of pre-flight (14.4–19.3 mmHg vs 16.3–20.3 mmHg) (p less than 0.05) for the left eye. Flight group had significant apoptosis in the retina and retinal vascular endothelial cells compared to control groups (p less than 0.05). Immunohistochemical analysis of the retina revealed that an increased expression of aquaporin-4 (AQP-4) in the flight mice compared to controls gave strong indication of disturbance of BRB integrity. There were also a significant increase in the expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) and a decrease in the expression of the BRB related tight junction protein, Zonula occludens-1 (ZO-1). Proteomic analysis showed that many key proteins and pathways responsible for cell death, cell cycle, immune response, mitochondrial function and metabolic stress were significantly altered in the flight mice compared to ground control animals. These data indicate a complex cellular response that may alter retina structure and BRB integrity following long-term spaceflight. This dataset derives results from the intraocular pressure (tonometry) assay.
GPR146 facilitates blood pressure elevation and vascular remodeling via PIEZO1
GEO Series GSE296321. Homo sapiens. 6 samples. Type: Other.
Quercetin treatment lower Angiotensin-II-induced blood pressure
GEO Series GSE207102. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Sex dependent compensatory mechanisms to preserve blood pressure homeostasis in PGI2 receptor deficient mice
GEO Series GSE115916. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing.
A Single-Short Partial Reprogramming of the Endothelial Cells in vivo decreases Blood Pressure and Vascular Contractility Through the Attenuation of Endothelial-to-Mesenchymal Transition in Male Hyper
GEO Series GSE300477. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Neferine treatment lower blood pressure in SHR
GEO Series GSE214655. Rattus norvegicus. 15 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic Alteration of Smooth Muscle Cells Regulates Endothelin-Dependent Blood Pressure and Hypertensive Arterial Remodeling [km_mouse]
GEO Series GSE292027. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic Alteration of Smooth Muscle Cells Regulates Endothelin-Dependent Blood Pressure and Hypertensive Arterial Remodeling [km_human_mouse]
GEO Series GSE292037. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Egg white-derived peptides decreased blood pressure via the competing endogenous RNA regulatory networks in female spontaneously hypertensive rats
GEO Series GSE242386. Rattus norvegicus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
An integrated network pharmacology and RNA-seq approach for exploring the vascular protection of neferine on attenuating Ang II-induced blood pressure elevation
GEO Series GSE229199. Mus. 17 samples. Type: Expression profiling by high throughput sequencing.
Ambulatory Blood Pressure Measurement in Children With Congenital Urine Flow Obstruction
ClinicalTrials.gov study NCT00764543. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Clinical Test for Armed-used Blood Pressure Monitor With Preformed Cuff(Monitor When Being Inflated)
ClinicalTrials.gov study NCT01206959. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Larsen & Toubro (L&T) Noninvasive Blood Pressure Module Performance Validation
ClinicalTrials.gov study NCT01097603. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Comparison of Measurement of Arterial Blood Pressure by L&T NIBP Module With Invasive Arterial Blood Pressure in Neonates
ClinicalTrials.gov study NCT01196806. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Calcium Intake, Metabolism, and Gestational Blood Pressure
ClinicalTrials.gov study NCT00005206. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS
ClinicalTrials.gov study NCT00005213. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Suppressed Anger, Blood Pressure and Mortality Follow-up
ClinicalTrials.gov study NCT00005458. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Blood Pressure and Diurnal Variation in Sodium, Potassium, and Water Excretion
ClinicalTrials.gov study NCT00005204. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Identification of primate renal salt-responsive gene networks that differ by blood pressure phenotype
GEO Series GSE18484. Homo sapiens; Papio hamadryas. 4 samples. Type: Expression profiling by array.
A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice
GEO Series GSE298954. Mus musculus. 40 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.