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1,981 results for “coronary artery”
Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1
<p>This record contains raw data related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1".</p> <p><strong>Rationale</strong>: Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of the present work was to address the role of mechanical forces in the activation of maladaptive vein bypass remodeling, a process determining progressive occlusion and recurrence of ischemic heart disease. <strong>Methods</strong>: We employed a custom bioreactor to mimic the coronary shear and wall mechanics in human SV vascular conduits and reproduce experimentally the biomechanical conditions of coronary grafting and analyzed vein remodeling process by histology, histochemistry and immunofluorescence. We also subjected vein-derived cells to cyclic uniaxial mechanical stimulation in culture, followed by phenotypic and molecular characterization using RNA and proteomic methods. We finally validated our results <em>in vitro</em> and using a model of SV carotid interposition in pigs. <strong>Results</strong>: Exposure to pulsatile flow determined a remodeling process of the vascular wall involving reduction in media thickness. Smooth muscle cells (SMCs) underwent conversion from contractile to synthetic phenotype. A time-dependent increase in proliferating cells expressing mesenchymal (CD44) and early SMC (SM22α) markers, apparently recruited from the SV adventitia, was observed especially in CABG-stimulated vessels. Mechanically stimulated SMCs underwent transition from contractile to synthetic phenotype. MALDI-TOF-based secretome analysis revealed a consistent release of Thrombospondin-1 (TSP-1), a matricellular protein involved in TGF-β-dependent signaling. TSP-1 had a direct chemotactic effect on SV adventitia resident progenitors (SVPs); this effects was inhibited by blocking TSP-1 receptor CD47. The involvement of TSP-1 in adventitial progenitor cells differentiation and graft intima hyperplasia was finally contextualized in the TGF-β-dependent pathway, and validated in a saphenous vein into carotid interposition pig model. <strong>Conclusions</strong>: Our results provide the evidence of a matricellular mechanism involved in the human vein arterialization process controlled by alterations in tissue mechanics, and open the way to novel potential strategies to block VGD progression based on targeting cell mechanosensing-related effectors.</p>
Spontaneous Coronary Artery Dissections: A Systematic Review
<p>This file contains raw data and tables regarding spontaneous coronary dissections diagnosed and treated at Monzino's hospital between 2007 and November 2021</p>
Computer-based prediction of coronary artery compression in the planning of transcatheter pulmonary valve implantation.
<p>Datset from Pluchinotta FR, Caimi A, Pilati M, Carminati M, Sturla F. Computer-based prediction of coronary artery compression in the planning of transcatheter pulmonary valve implantation. EuroIntervention. 2021 Sep 20;17(7):584-585. doi: 10.4244/EIJ-D-20-01114. PMID: 33433388.</p> <p> </p>
Dataset related to the article "Diagnostic accuracy of subendocardial vs. transmural myocardial perfusion defect for the detection of in-stent restenosis or progression of coronary artery disease after percutaneous coronary intervention
<p>This record contains raw datarelated to the article"Diagnostic accuracy of subendocardial vs. transmural myocardial perfusion defect for the detection of in-stent restenosis or progression of coronary artery disease after percutaneous coronary intervention</p> <p> </p> <p>Background. The ADVANTAGE study demonstrated in a cohort of stented patients a diagnostic accuracy of stress myocardial CT perfusion (CTP) significantly higher than that of coronary CT angiography (CCTA) for the detection of in-stent restenosis (ISR) or CAD progression vs. quantitative coronary angiography (QCA). This is a pre-defined subanalysis of the ADVANTAGE aimed at assessing the difference in terms of diagnostic accuracy vs. QCA of a subendocardial vs. a transmural perfusion defect using static stress CTP.<br> Methods. We enrolled consecutive patients who previously underwent coronary stenting and were referred for QCA. All patients underwent stress CTP and rest CTP+CCTA. The diagnostic accuracy of CCTA and CTP were evaluated in territory-based and patient-based analyses. We compared the diagnostic accuracy of “subendocardial” perfusion defect, defined as hypo-enhancement encompassing >25% but <50% of the transmural myocardial thickness within a specific coronary territory vs. “transmural” perfusion defect, defined as hypo-enhancement encompassing >50% of the transmural thickness.<br> Results. In 150 patients (132 men, mean age 65.1±9.1 years), the diagnostic accuracy of subendocardial vs. transmural perfusion defect in a vessel-based analysis was 93.5% vs. 87.7%, respectively (p<0.0001). The sensitivity and specificity of subendocardial vs. transmural defect were 87.9% vs. 46.9% (p<0.001) and 94.9% vs. 97.9% (p=0.004), respectively. In a patient-based analysis, the diagnostic accuracy of the subendocardial vs. transmural approach was 86.6% vs. 68% (p<0.0001).<br> Conclusions. This study shows that detection of a subendocardial perfusion defect as compared to a transmural defect is significantly more accurate to identify coronary territories with ISR or CAD progression.</p> <p> </p>
Comprehensive analysis of RNA expression profiling in patients with multi- vs single-vessel coronary artery disease
GEO Series GSE190627. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Utilizing combined spatial transcriptomics to elucidate localized immune responses within human coronary arteries throughout the progression of atherosclerosis
GEO Series GSE277170. blank sample; Homo sapiens. 56 samples. Type: Other.
To study the genomic changes in senescent porcine coronary arterial endothelial cells by multiple passaging in vitro
GEO Series GSE8974. Sus scrofa. 9 samples. Type: Expression profiling by array.
Transcriptional profiling of calcifying human primary coronary artery smooth muscle cells
GEO Series GSE284683. Homo sapiens. 9 samples. Type: Expression profiling by array.
Microarray analysis to identify differential molecular signatures in subjects with stable coronary artery disease on standard dosage regimens versus healthy controls
GEO Series GSE56885. Homo sapiens. 6 samples. Type: Expression profiling by array.
Endothelial transcriptional profiles of porcine coronary and iliac arteries passages 1 through 4
GEO Series GSE19593. Sus scrofa. 29 samples. Type: Expression profiling by array.
Global gene expression studies for coronary artery disease and its severity in North Indian population
GEO Series GSE98583. Homo sapiens. 18 samples. Type: Expression profiling by array.
Dataset related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1"
<p>This record contains graph data related to the article “<strong>Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1</strong>”</p> <p> </p> <p>Abstract</p> <p><strong>Rationale</strong> - Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of the present work was to address the role of mechanical forces in the activation of maladaptive vein bypass remodeling, a process determining progressive occlusion and recurrence of ischemic heart disease.</p> <p><strong>Methods </strong>- We employed a custom bioreactor to mimic the coronary shear and wall mechanics in human SV vascular conduits and reproduce experimentally the biomechanical conditions of coronary grafting and analyzed vein remodeling process by histology, histochemistry and immunofluorescence. We also subjected vein-derived cells to cyclic uniaxial mechanical stimulation in culture, followed by phenotypic and molecular characterization using RNA and proteomic methods. We finally validated our results <em>in vitro</em> and using a model of SV carotid interposition in pigs.</p> <p><strong>Results - </strong>Exposure to pulsatile flow determined a remodeling process of the vascular wall involving reduction in media thickness. Smooth muscle cells (SMCs) underwent conversion from contractile to synthetic phenotype. A time-dependent increase in proliferating cells expressing mesenchymal (CD44) and early SMC (SM22α) markers, apparently recruited from the SV adventitia, was observed especially in CABG-stimulated vessels. Mechanically stimulated SMCs underwent transition from contractile to synthetic phenotype. MALDI-TOF-based secretome analysis revealed a consistent release of Thrombospondin-1 (TSP-1), a matricellular protein involved in TGF-β-dependent signaling. TSP-1 had a direct chemotactic effect on SV adventitia resident progenitors (SVPs); this effects was inhibited by blocking TSP-1 receptor CD47. The involvement of TSP-1 in adventitial progenitor cells differentiation and graft intima hyperplasia was finally contextualized in the TGF-β-dependent pathway, and validated in a saphenous vein into carotid interposition pig model.</p> <p><strong>Conclusions -</strong> Our results provide the evidence of a matricellular mechanism involved in the human vein arterialization process controlled by alterations in tissue mechanics, and open the way to novel potential strategies to block VGD progression based on targeting cell mechanosensing-related effectors.</p>
Data set from the article Bari V, Vaini E, Pistuddi V, Fantinato A, Cairo B, De Maria B, Ranucci M, Porta A. Short-term multiscale complexity analysis of cardiovascular variability improves low cardiac output syndrome risk stratification after coronary artery bypass grafting. Physiol Meas. 2019 Apr 26;40(4):044001. doi: 10.1088/1361-6579/ab12f0. PMID: 30909175.
<p>Data set from the article Bari V, Vaini E, Pistuddi V, et al. Short-term multiscale complexity analysis of cardiovascular variability improves low cardiac output syndrome risk stratification after coronary artery bypass grafting. <em>Physiol Meas</em>. 2019;40(4):044001. Published 2019 Apr 26. doi:10.1088/1361-6579/ab12f0</p> <p>This is the abstract:</p> <p><strong>Background: </strong>Low cardiac output syndrome (LCOS) is a myocardial dysfunction leading to systemic hypoperfusion, favored by particular conditions of the autonomic nervous system. LCOS is one of the adverse events that might occur after cardiac surgery.</p> <p><strong>Objective: </strong>The aim is to test the hypothesis that short-term multiscale complexity (MSC) analysis of heart period (HP) and systolic arterial pressure (SAP) variability series in the frequency bands typical of cardiovascular control could be fruitfully exploited in identifying subjects at risk of developing LCOS after coronary artery bypass graft (CABG).</p> <p><strong>Approach: </strong>HP and SAP beat-to-beat series were derived from electrocardiogram (ECG) and invasive arterial pressure (AP) signal acquired in 128 patients scheduled for CABG before (PRE) and after (POST) the induction of general anesthesia with propofol and remifentanil. Subjects were labeled as LCOS (n = 14) and noLCOS (n = 114) according to the LCOS development. MSC markers were calculated as the complement to 1 of the modulus of the average position of the poles dropping in the low-frequency (LF, 0.04-0.15 Hz) and high-frequency (HF, 0.15-0.5 Hz) bands as derived from the autoregressive model of HP and SAP series. Traditional time and frequency domain indexes were also calculated.</p> <p><strong>Main results: </strong>Traditional parameters were able to assess the depression of the cardiovascular regulation induced by general anesthesia, but showed weak performances in differentiating LCOS and noLCOS groups. Conversely, HP complexity in LF band and SAP complexity in HF band assessed during POST remained associated with LCOS even after entering a multivariate logistic regression model adjusted for clinical and demographic factors.</p> <p><strong>Significance: </strong>The MSC approach can be fruitfully applied to improve risk stratification for LCOS after CABG likely because MSC markers describe the dysfunction of the sympathetic control and the impairment of the mechanical properties of the heart in the LCOS group.</p>
Data set from the article Vaini E, Bari V, Fantinato A, Pistuddi V, Cairo B, De Maria B, Ranucci M, Porta A. Causality analysis reveals the link between cerebrovascular control and acute kidney dysfunction after coronary artery bypass grafting. Physiol Meas. 2019 Jul 1;40(6):064006. doi: 10.1088/1361-6579/ab21b1. PMID: 31091519.
<p>Data set from the article Vaini E, Bari V, Fantinato A, et al. Causality analysis reveals the link between cerebrovascular control and acute kidney dysfunction after coronary artery bypass grafting. <em>Physiol Meas</em>. 2019;40(6):064006. Published 2019 Jul 1. doi:10.1088/1361-6579/ab21b1</p> <p>This is the abstract:</p> <p><strong>Background: </strong>Patients undergoing coronary artery bypass graft (CABG) surgery might experience postoperative complications and some of them, such as acute kidney dysfunction (AKD), are the likely consequence of hypoperfusion. We hypothesized that an impaired cerebrovascular control is a hallmark of a vascular damage that might favor AKD after CABG.</p> <p><strong>Objective: </strong>Our aim is to characterize cerebrovascular control in CABG patients through the assessment of the relationship between mean arterial pressure (MAP) and mean cerebral blood flow velocity (MCBFV) and to check whether markers describing MCBFV-MAP dynamical interactions could identify subjects at risk to develop postoperative AKD.</p> <p><strong>Approach: </strong>MAP and MCBFV beat-to-beat series were extracted from invasive arterial pressure and transcranial Doppler recordings acquired simultaneously in 23 patients just before CABG after the induction of propofol general anesthesia. Subjects were divided into AKD group (n = 9, age: 68 ± 9, 8 males) and noAKD group (n = 14, age: 65 ± 8, 12 males) according to whether they developed postoperative AKD or not after CABG. We computed MAP and MCBFV time-domain and spectral markers as well as MCBFV-MAP cross-spectral indexes in very-low-frequency (VLF, 0.02-0.07 Hz), low-frequency (LF, 0.07-0.15 Hz) and high-frequency (HF, 0.15-0.30 Hz) bands. We also calculated model-based transfer entropy (TE) to quantify the degree of MCBFV dependence on MAP and vice versa. The null hypothesis of MCBFV-MAP uncoupling was tested via a surrogate approach associating MAP and MCBFV in different patients.</p> <p><strong>Main results: </strong>Time, spectral and cross-spectral markers had a limited power in separating AKD from noAKD individuals. Conversely, TE from MAP to MCBFV was significantly above the level set by surrogates only in AKD groups and significantly larger than that computed in noAKD.</p> <p><strong>Significance: </strong>The reduced cerebrovascular autoregulation in AKD patients suggest a vascular impairment likely making them more at risk of hypoperfusion during CABG and AKD after CABG.</p>
Data set from the article Petrini M, Alì M, Cannaò PM, Zambelli D, Cozzi A, Codari M, Malavazos AE, Secchi F, Sardanelli F. Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging. Clin Radiol. 2019 Jan;74(1):81.e1-81.e7. doi: 10.1016/j.crad.2018.09.006. Epub 2018 Oct 15. PMID: 30336943.
<p>Data set from the article Petrini M, Alì M, Cannaò PM, Zambelli D, Cozzi A, Codari M, Malavazos AE, Secchi F, Sardanelli F. Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging. Clin Radiol. 2019 Jan;74(1):81.e1-81.e7. doi: 10.1016/j.crad.2018.09.006. Epub 2018 Oct 15. PMID: 30336943.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Aim: </strong> To compare the amount of epicardial adipose tissue (EAT) in patients with coronary artery disease (CAD) or non-ischaemic dilated cardiomyopathy (NIDCM) with that in patients with negative cardiac magnetic resonance imaging (CMR).</p> <p><strong>Materials and methods: </strong> One hundred and fifty patients (median age 57 years, interquartile range [IQR] 46-66 years) who underwent CMR were evaluated retrospectively: 50 with CAD, 50 with NIDCM, and 50 with negative CMR. For each patient, the EAT mass index (EATMI) to body surface area, end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume (SV), ejection fraction (EF) for both ventricles, and left ventricle (LV) mass index were estimated. Intra and inter-reader reproducibility was tested in a random subset of 30 patients, 10 for each group. Mann-Whitney U test, Kruskal-Wallis test, Spearman's correlation, and Bland-Altman statistics were used.</p> <p><strong>Results: </strong> The EATMI in CAD patients (median 15.7 g/m<sup>2</sup>, IQR 8.3-25.7) or in NIDCM patients (15.9 g/m<sup>2</sup>, 11.5-18.1) was significantly higher than that in negative CMR patients (9.1 g/m<sup>2</sup>, 6-12; p<0.001 both). No significant difference was found between CAD and NIDCM patients (p=1.000). A correlation between EATMI and LV mass index was found in NIDCM patients (r=0.455, p=0.002). Intra- and inter-reader reproducibility were up to 80% and 72%, respectively.</p> <p><strong>Conclusion: </strong> Patients with NIDCM or CAD exhibited an increased EATMI in comparison to negative CMR patients. CMR can be used to estimate EAT with good reproducibility.</p>
Dataset related to article "SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry"
<p>This record contains raw data related to article "SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry"</p><p><strong>Abstract</strong></p><p><strong>Background: </strong>In the setting of coronary artery dissection, both spontaneous and iatrogenic, fixing the intimal tear, usually with stent implantation, can be extremely challenging if the distal wire position has been lost. Common complications are mainly related to the inadvertent subintimal tracking of the guidewire while attempting to gain the distal true lumen.</p><p><strong>Aims: </strong>To report the registry results of using the SUOH 0.3 guidewire for managing coronary artery dissection in a real-world multicenter setting.</p><p><strong>Methods: </strong>The study population in this retrospective, multicenter, international registry included 75 consecutive patients who underwent PCI and required an antegrade wiring of a dissected coronary artery.</p><p><strong>Results: </strong>Successful use of SUOH 0.3 was achieved in 69 (92%) patients. The use of a microcatheter was associated with a significantly higher rate of TIMI 3 flow at the end of the procedure (no microcatheter: <i>n</i> = 17, 81%; microcatheter: <i>n</i> = 52, 96.3%; <i>p</i> = 0.017). The first recanalization attempt was made with the SUOH 03 guidewire in 48 (64%) cases, and it was successful in 42 (87%). The overall PCI success rate was reported in 72 (96%) patients, with no significant differences among patients with different origins, mechanisms, and locations of dissection.</p><p><strong>Conclusions: </strong>In this setting, the SUOH 0.3 guidewire provides high procedural success without additional complex techniques.</p>
Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients
<p>This record contains raw data related to the article “Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients”<strong>Background:</strong> Current knowledge regarding the relationship between aortic valve sclerosis (AVSc), cardiovascular risk factors, and mortality in patients with known coronary artery disease (CAD) is still unclear. The present study aimed at investigating the prevalence of AVSc as well as its association with long-term all-cause mortality in high-risk CAD patients that has never been explored in large cohorts thus far. <strong>Methods and Results:</strong> In this retrospective and observational cohort study we enrolled high-risk CAD patients, hospitalized at Centro Cardiologico Monzino (CCM), Milan, Italy, between January 2006 and December 2016. The morphology and function of the aortic valve were assessed from the recorded echocardiographic images to evaluate the presence of AVSc, defined as a non-uniform thickening of the aortic leaflets with no consequences on hemodynamics. Data on 5-year all-cause mortality was retrieved from a Regional database. Of the 5,489 patients initially screened, 4,938 (mean age 67 ± 11 years, 3,954 [80%] men) were enrolled in the study. In the overall population, AVSc was detected in 2,138 (43%) patients. Multivariable LASSO regression revealed that age, female gender, diabetes mellitus, previous MI, and left ventricular ejection fraction were independently associated with AVSc. All-cause mortality (adjusted hazard ratio: 1.29, 95%CI: 1.05-1.58) was significantly higher in AVSc than in non-AVSc patients. <strong>Conclusions:</strong> AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. Our findings corroborate the hypothesis that AVSc is an underestimated marker of systemic cardiovascular risk. Thus, AVSc detection may be used to improve long-term risk stratification of high-risk CAD patients.</p>
Does chest shape influence exercise stress echocardiographic results in patients with suspected coronary artery disease?
<p>Raw data related to the article</p> <p>Abstract<br> Despite the good specificity of exercise stress echocardiography (ESE) for the detection of coronary artery disease (CAD),<br> false positive (FP) results may occur. We have previously reported that chest abnormalities may affect parameters of cardiac<br> contractility. The influence of chest shape on ESE results has never been previously investigated. We retrospectively analyzed<br> 160 consecutive patients (64.4 ± 13.0-year old, 91 women) who had undergone coronary angiography at our Institution<br> because of positive ESE, between June 2014 and May 2020. Modified Haller index (MHI; chest transverse diameter over<br> the distance between sternum and spine) was assessed in all patients. Obstructive CAD was diagnosed by ≥ 70% stenosis<br> in any epicardial coronary artery. Outcome was false-positivity at ESE. 80.6% of patients were diagnosed with obstructive<br> CAD, while 19.4% had no CAD (FP). We separately analyzed patients with normal chest shape (MHI ≤ 2.5) and those with<br> concave-shaped chest wall (MHI > 2.5). These latter were mostly women with small cardiac chambers, mitral valve prolapse<br> (MVP) and exercise-induced ST-segment changes. Likelihood of false-positivity was significantly higher in subjects with<br> MHI > 2.5 than those with MHI ≤ 2.5 (30.7% vs 9.4%, p = 0.001). By multivariate logistic regression analysis, MHI > 2.5<br> (OR 4.04, 95%CI 1.45–11.2, p = 0.007), MVP (OR 3.47, 95%CI 1.32–9–12, p = 0.01) and dyssynergy in the left circumflex<br> territory (OR = 3.35, 95%CI 1.26–8.93, p = 0.01) were independently associated with false-positivity. Concave-shaped chest<br> wall (MHI > 2.5) may be associated with false-positive stress echocardiographic result. Mechanisms underpinning this finding<br> need to be further explored.</p>
Appropriate use criteria implementation with modified Haller index for predicting stress echocardiographic results and outcome in a population of patients with suspected coronary artery disease
<p>Raw data related to the article</p> <p>Abstract<br> The hypothesis that modified Haller index (MHI) integration with the existing appropriate use criteria (AUC) categories may<br> predict exercise stress echocardiography (ESE) results and outcome of patients with suspected coronary artery disease (CAD)<br> has never been previously investigated. We retrospectively analyzed 1230 consecutive patients (64.8 ± 13.1 years, 58.9%<br> men) who underwent ESE for suspected CAD between February 2011 and September 2019 at our institution. MHI (chest<br> transverse diameter over the distance between sternum and spine) was assessed in all patients. A true positive (TP) ESE was<br> a positive ESE with obstructive CAD according to subsequent coronary angiography. During follow-up time, we evaluated<br> the occurrence of any of the following: (1) cardiovascular (CV) hospitalizations; (2) Cardiac death or sudden death. Overall,<br> 734 (59.7%), 357 (29.0%) and 139 (11.3%) indications for ESE were classified as appropriate (Group 1), rarely appropriate<br> (Group 2) and which may be appropriate (Group 3), respectively. A funnel chest (defined by an MHI > 2.5) was detected<br> in 30.3%, 82.1% and 49.6% of Groups 1, 2 and 3 subjects, respectively (p < 0.0001). On multivariate logistic regression<br> analysis, male sex (OR 1.41, 95%CI 1.02–2.03, p = 0.01) and type-2 diabetes (OR 3.63, 95%CI 2.49–5.55, p = 0.001) were<br> directly correlated to a TP ESE, while “rarely appropriate” indication for ESE with MHI > 2.5 (OR 0.16, 95%CI 0.11–0.22,<br> p < 0.0001) showed a significant inverse correlation with the outcome. During a mean follow-up of 2.5 ± 1.9 years, 299 CV<br> events occurred: 76.4%, 3.5% and 20.1% in Groups 1, 2 and 3, respectively. On multivariate Cox regression analysis, smoking<br> (HR 1.33, 95%CI 1.19–1.48), type 2 diabetes (HR 2.28, 95%CI 1.74–2.97), dyslipidemia (HR 3.51, 95%CI 2.33–5.15), betablockers<br> (HR 0.55, 95%CI 0.41–0.75), statins (HR 0.60, 95%CI 0.45–0.80), peak exercise average E/e′ ratio (HR 1.08, 95%CI<br> 1.06–1.09), positive ESE (HR 3.12, 95%CI 2.43–4.01) and finally “rarely appropriate” indication for ESE with MHI > 2.5<br> (HR 0.15, 95%CI 0.08–0.23) were independently associated with CV events. The implementation of AUC categories with<br> MHI assessment may select a group of patients with extremely low probability of both TP ESE and adverse CV events over<br> a medium-term follow-up. A simple noninvasive chest shape assessment could reduce unnecessary exams.</p>
Long-term secondary cardiovascular prevention programme in patients subjected to coronary artery bypass surgery
<p><strong>Aims: </strong>Patients with coronary heart disease (CHD) are at very high risk of recurrent events. A strategy to reduce excess risk might be to deliver structured secondary prevention programmes, but their efficacy has been mostly evaluated in the short term and in experimental settings. This is a retrospective case–control study aimed at assessing, in the real world, the efficacy of a secondary prevention programme in reducing long-term coronary event recurrences after coronary artery bypass surgery (CABG). </p> <p><strong>Methods and results:</strong> Programme participants (henceforth ‘cases’) were men and women aged <75 years subjected to CABG between 2002 and 2014, living within 100 km of the hospital. Key programme actions included optimization of treatments according to the most updated European preventive guidelines, surveillance of therapy adherence, and customized lifestyle counselling. Controls were analogous patients not involved in the programme because living farther than 100 km away, matched 1:1 with cases for gender, age at CABG, and year of CABG. Both groups (n = 1248) underwent usual periodic cardiology follow-up at our centre. Data on symptomatic or silent CHD recurrences were obtained from the hospital electronic health records. Cox analysis (adjusted for baseline differences between groups) shows that programme participation was associated with a significantly lower incidence throughout 5 years post-CABG of symptomatic [hazard ratio (95% confidence interval): 0.59 (0.38–0.94)] and silent [0.53 (0.31–0.89)] coronary recurrences. </p> <p><strong>Conclusion:</strong> In a real-world setting, taking part in a structured longstanding secondary prevention programme, in addition to usual cardiology care, meaningfully lowers the risk of coronary recurrences.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.