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ShareScore release 0.9.0
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13 results for “AXON DEGENERATION”
Histological validation of per-bundle water diffusion metrics within a region of fiber crossing following axonal degeneration
<p>Interactive plots showing the correlation between histological parameters of optic nerves and chiasm, and metrics derived from diffusion MRI in a rat model of unilateral retinal ischemia.</p> <p> </p> <p>There are two .html files, each containing an interactive figure, one for data pertaining to the optic nerve, the other for the chiasm. The left panel shows the correlation matrix. Click on any cell to see the corresponding scatter plot on the right panel. </p>
Histological validation of per-bundle water diffusion metrics within a region of fiber crossing following axonal degeneration - Synthetic data
<p>Analysis of dMRI of the optic chiasm using CSD revealed unexpectedly high AFD of the intact bundle in the experimental animals. To evaluate whether this finding is an artifact produced by CSD, we used analytic synthetic data. Using the multi-tensor model, two sets of synthetic dMRI data were created consisting of 100 voxels, each with two tensors crossing at right angles. For each voxel, one tensor was modelled as an “intact” fiber bundle, following the DTI metrics observed in our experimental data (λ∥=0.64 and λ⟂=0.12 ×10-3 mm²/s), while the other tensor was modelled as an “injured” fiber bundle (λ∥=0.42 and λ⟂=0.22 ×10-3 mm²/s). Volume fractions were set as f=0.5 for both tensors. The multi-shell scheme to generate the synthetic signals consisted of 20 b=0 s/mm², and 160 DWI volumes, consisting of 80 diffusion gradient orientations, each with two distinct b values, namely b=1000 and 3000 s/mm². Signal-to-noise ratio was set at 20. </p> <p>Diffusion-weighted parameters are shown in the corresponding *protocol.txt files, organized as in the MRtrix gradient scheme (https://mrtrix.readthedocs.io/en/latest/concepts/dw_scheme.html), namely one row per volume, each containing the vector [x y z b], where x, y, and z, correspond to the components of the diffusion gradient direction, and b is the b value in s/mm^2.</p> <p>Refers to:</p> <p>Rojas-Vite, Gilberto, Coronado-Leija, Ricardo, Narvaez-Delgado, Omar, Ramirez-Manzanares, Alonso, Marroquin, Jose-Luis, Noguez-Imm, Ramses, Aranda, Marcos L, Scherrer, Benoit, Larriva-Sahd, Jorge, Concha, Luis: Histological validation of per-bundle water diffusion metrics within a region of fiber crossing following axonal degeneration , Available at bioRxiv, doi.org/10.1101/571539, 2019.</p>
Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration
ClinicalTrials.gov study NCT03912220. IPD Sharing: NO. Countries: 1. Publications: 0.
Restoring Mitofusin balance in the nervous system prevents axonal degeneration in a CMT2A mouse model
GEO Series GSE116863. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
GEO Series GSE222063. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo and modulates differential splicing
GEO Series GSE123687. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Cytotoxic CNS-associated T cells drive axon degeneration in aging and myelin disease
GEO Series GSE138891. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of Schwann cell gene expression in LKB1-SCKO mutant mice prior to occurrence of axon degeneration
GEO Series GSE60325. Mus musculus. 4 samples. Type: Expression profiling by array.
Genetically perturbed myelin as a risk factor for neuroinflammation-driven axon degeneration
GEO Series GSE224032. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Macrophages protect against sensory axon degeneration in diabetic neuropathy
GEO Series GSE255553. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Regeneration After Ischemic Stroke
GEO Series GSE280862. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Rac1 impairs retinal axon degeneration via Kif2a in a mouse model of chronic ocular hypertension
GEO Series GSE247696. Mus musculus. 2 samples. Type: Other.
Multi-kinase inhibition of STE20 kinases is neuroprotective against chemotherapy-induced axon degeneration
GEO Series GSE298389. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.