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31 results for “Acanthamoeba”
Fig. 3 in Tannic acid-modified silver nanoparticles enhance the anti-ACanthamoeba activity of three multipurpose contact lens solutions without increasing their cytotoxicity
Fig. 3 Anti-Acanthamoeba activity of AgTANPs conjugated with ReNu MultiPlus contact lens solution after 6 h of incubation in relation to cytotoxicity
Fig. 5 a–d Acanthamoeba trophozoites after 6 h in Tannic acid-modified silver nanoparticles enhance the anti-ACanthamoeba activity of three multipurpose contact lens solutions without increasing their cytotoxicity
Fig. 5 a–d Acanthamoeba trophozoites after 6 h of incubation. a Control culture in PYG medium. b Incubation with AgTANPs. c Incubation with SCA. d Incubation with AgTANPs conjugated with SCA.The arrow shows a rounded form. All images (× 40) represent the population of treated amoebae and were taken under a live cell imaging microscope (EVOS FLoid Cell Imaging Station). For abbreviations, see Figs. 1 and 2
Fig. 2 in Tannic acid-modified silver nanoparticles enhance the anti-ACanthamoeba activity of three multipurpose contact lens solutions without increasing their cytotoxicity
Fig. 2 Anti-Acanthamoeba activity of AgTANPs conjugated with Solo Care Aqua (SCA) contact lens solution after 6 h of incubation in relation to cytotoxicity
Fig. 4 in Tannic acid-modified silver nanoparticles enhance the anti-ACanthamoeba activity of three multipurpose contact lens solutions without increasing their cytotoxicity
Fig. 4 Anti-Acanthamoeba activity of AgTANPs conjugated with Opti-Free contact lens solution after 6 h of incubation in relation to cytotoxicity
Fig. 1 in Tannic acid-modified silver nanoparticles enhance the anti-ACanthamoeba activity of three multipurpose contact lens solutions without increasing their cytotoxicity
Fig. 1 High-resolution scanning transmission electron microscopy image of the distribution and diameters of the tannic acid-modified silver nanoparticles (AgTANPs)
Fig. 4 in First Report of a Case of Prostatitis Due to Acanthamoeba in a Dog
Fig. 4. Phylogenetical analysis of the DF3 sequence of the Acanthamoeba strain isolated from the prostate revealed that the strain belonged to genotype T4.
Pseudomonas aeruginosa secretes compounds that kill Acanthamoeba castellanii trophozoites
<p>Microscopy of A. castellanii trophozoites incubated with cell-free supernatant from P. aeruginosa strain PA14 overnight cultures in LB. Time elapsed 2 hours. Video acquired using a Canon Vixia HFS200 camera and Nikon Eclipse TS100 microscope (20x objective).</p>
Acanthamoeba castellanii genome assembly and infection by Legionella pneumophila
<p>Data associated with the publication "<em>Regulation of the Acanthamoeba castellanii genome upon infection by Legionella pneumophila</em>". The record contains 4 archives, each associated with a github repository, and a "shared assets" archive, which contains processed files used by some repositories. The code from github repositories is embedded in each tarball, along with input and output data. Analyses are organized as independent snakemake pipelines for each part.</p> <p> </p> <p>For convenient reanalysis, genomes, annotations and merged contact maps used in the publication can be found in the `shared_assets.tar.gz` archive. The infection analysis results are located in the `data/output` folder of Acastellanii_legionella_infection.tar.gz.</p> <p>All archives can be downloaded at the bottom of the page.</p> <p> </p> <p><strong>Hybrid genome assembly:</strong></p> <p>Genome assembly pipeline code and output data used for the assembly of 2 <em>A. castellanii</em> strains (Neff and C3) through a hybrid pipeline combining Illumina shotgun, Hi-C and Oxford Nanopore long reads.</p> <p>Github: <a href="https://github.com/cmdoret/Acastellanii_hybrid_assembly">https://github.com/cmdoret/Acastellanii_hybrid_assembly</a></p> <p>Archive: Acastellanii_hybrid_assembly.tar.gz</p> <p> </p> <p><strong>Genome annotation:</strong></p> <p>Genome annotation pipeline used for functional annotation of <em>A. castellanii</em> strains C3 and Neff, and associated output files.</p> <p>Github: <a href="https://github.com/cmdoret/Acastellanii_genome_annotation">https://github.com/cmdoret/Acastellanii_genome_annotation</a></p> <p>Archive: Acastellanii_genome_annotation.tar.gz</p> <p> </p> <p><strong>Genome analyses:</strong></p> <p>Code and data related to general analyses of genomic properties of <em>A. castellanii</em> strains C3 and Neff.</p> <p>Github: <a href="https://github.com/cmdoret/Acastellanii_genome_analysis">https://github.com/cmdoret/Acastellanii_genome_analysis</a></p> <p>Archive: Acastellanii_genome_analysis.tar.gz</p> <p> </p> <p><strong>Infection analyses:</strong></p> <p>Code and data related to the analysis of structural changes in the <em>A. castellanii</em> C3 genome during infection by <em>L. pneumophila</em>.</p> <p>Github: <a href="https://github.com/cmdoret/Acastellanii_legionella_infection">https://github.com/cmdoret/Acastellanii_legionella_infection</a></p> <p>Archive: Acastellanii_legionella_infection.tar.gz<br> </p> <p><strong>Shared assets:</strong></p> <p>This archive contains processed files (genomes, annotations, Hi-C matrices, differential expression results) which can be useful for reanalysis, and are automatically pulled when executing the pipeline of some repositories.</p> <p>Archive: shared_assets.tar.gz</p> <p> </p> <p><strong>Supp. analyses:</strong></p> <p>Code and data related to short ad-hoc analyses on the genomic location of specific sequences in the genomes of C3 and Neff. The archive contains two subfolders: `telomere_repeats` where we analyse the distribution of TTAGGG subtelomeric repeats throughout the A. castellanii assemblies, and `C3_exclusive_regions` where we visualize the genomic distribution of C3-specific sequences (i.e. absent from Neff) along the C3 assembly.</p> <p> </p> <p>Archive: supp_analyses.tar.gz<br> </p>
Fig. 1 in Genotype diversity, phylogenetic analysis and seasonality of isolates of Acanthamoeba spp. in swimming pools in Kafrelsheikh, Egypt
Fig. 1. Fresh unstained trophozoites (A) and cysts (B–D) of Acanthamoeba spp.
Data from: Human conjunctival transcriptome in Acanthamoeba keratitis: An exploratory study
<p>The host conjunctival transcriptome of 9 patients with <em>Acanthamoeba</em> keratitis (AK) is compared to the conjunctival transcriptome of 13 patients with keratitis and no identified pathogen. Pathway enrichment analysis identified thirty-six transcripts as most differentially expressed between patients with AK compared to patients with presumed sterile keratitis.</p>
Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis
ClinicalTrials.gov study NCT03274895. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Data from: Human conjunctival transcriptome in Acanthamoeba keratitis: An exploratory study
Open the record for dataset details and reuse information.
Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/ml Polihexanide
ClinicalTrials.gov study NCT06641882. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Fig. 1 in First Report of a Case of Prostatitis Due to Acanthamoeba in a Dog
Fig. 1. Echography of the prostate showing alteration of the pros- tatic parenchyma, with various irregular anechoic foci and multiple hyperechoic dotted pattern with non-defined margins.
Fig. 3. Acanthamoeba specific PCR using JDP1 in First Report of a Case of Prostatitis Due to Acanthamoeba in a Dog
Fig. 3. Acanthamoeba specific PCR using JDP1/JDP2 primers. Lane 1: Molecular Weight Marker 100bp ladder; Lane 2: Prostate Fluid; Lane 3: Non-Nutrient Agar Amoebic Culture; Lane 4: Axenic culture; Lane 5: Positive control Acanthamoeba castellani Neff ATCC 30010 DNA; Lane 6: Negative control, bidistilled water.
Data from: Adhesion forces and mechanics in mannose-mediated acanthamoeba interactions
The human pathogenic amoeba Acanthamoeba castellanii (A. castellanii) causes severe diseases, including acanthamoeba keratitis and encephalitis. Pathogenicity arises from the killing of target-cells by an extracellular killing mechanism, where the crucial first step is the formation of a close contact between A. castellanii and the target-cell. This process is mediated by the glycocalix of the target-cell and mannose has been identified as key mediator. The aim of the present study was to carry out a detailed biophysical investigation of mannose-mediated adhesion of A. castellanii using force spectroscopy on single trophozoites. In detail, we studied the interaction of a mannose-coated cantilever with an A. castellanii trophozoite, as mannose is the decisive part of the cellular glycocalix in mediating pathogenicity. We observed a clear increase of the force to initiate cantilever detachment from the trophozoite with increasing contact time. This increase is also associated with an increase in the work of detachment. Furthermore, we also analyzed single rupture events during the detachment process and found that single rupture processes are associated with membrane tether formation, suggesting that the cytoskeleton is not involved in mannose binding events during the first few seconds of contact. Our study provides an experimental and conceptual basis for measuring interactions between pathogens and target-cells at different levels of complexity and as a function of interaction time, thus leading to new insights into the biophysical mechanisms of parasite pathogenicity.
Fig. 2 in Genotype diversity, phylogenetic analysis and seasonality of isolates of Acanthamoeba spp. in swimming pools in Kafrelsheikh, Egypt
Fig. 2. The maximum-likelihood constructed phylogenetic tree of Acanthamoeba isolates inferred from the small subunit ribosomal RNA gene sequences from GenBank showing the phylogenetic position of three strains detected in the present study; T4 (blue), T9 (green) and T11 (red). The tree with the highest log likelihood (-1201.92) is shown.
Acanthamoeba and Artificial Intelligence
ClinicalTrials.gov study NCT06332703. IPD Sharing: Not stated. Countries: 0. Publications: 6.
Data from: Adhesion forces and mechanics in mannose-mediated acanthamoeba interactions
Open the record for dataset details and reuse information.
Campylobacter jejuni interactions with Acanthamoeba castellanii
GEO Series GSE206909. Campylobacter jejuni; Acanthamoeba castellanii. 6 samples. Type: Expression profiling by high throughput sequencing.
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