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836 results for “Acute kidney injury”
Unveiling Pathophysiological Insights: Serum Metabolic Dysregulation in Acute Respiratory Distress Syndrome Patients with Acute Kidney Injury
<p>The uploaded data is an Excel sheet obtained after performing the binning of 1H CPMG NMR spectra acquired using 800 MHz NMR on the serum samples of ARDS patients and ARDS with AKI patients. </p>
Immune checkpoint molecule TIGIT regulates kidney T cell functions and mediates acute kidney injury
<p>This dataset includes the single cell RNA-seq data associated with the publication listed in the title (abstract below).<br> <br> CellRanger.zip contains the raw transcript counts as produced by CellRanger. There is one folder per sample. The samples are indicated by the folder name (e.g. KO_Ctrl). <br> <br> We have also included .h5ad files that contain of cells that passed quality control, as described in the manuscript.<br> <br> adTIGIT_raw_031422.h5ad contains all passing cells and the raw counts, as well as cell annotations ('celltype')<br> <br> adTIGIT_Tonly_091421.h5ad contains only T cells, .X contains the normalized data and T-cell sub-type ('cluster').<br> <br> Abstract: T cells mediate pathologic and reparative processes during acute kidney injury (AKI) but exact mechanisms regulating kidney T cell functions are unclear. This study identified upregulation of the novel immune checkpoint molecule, TIGIT, on mouse and human kidney T cells following AKI. TIGIT-expressing kidney T cells produced proinflammatory cytokines and had effector and central memory phenotype. Kidney Tregs were predominantly TIGIT+ and reduced after ischemia reperfusion (IR) injury. TIGIT deficient mice had protection from both ischemic and nephrotoxic AKI. Single cell RNA sequencing led to discovery of possible downstream targets of TIGIT. TIGIT mediates AKI pathophysiology, is a promising target for developing AKI therapy, and is being increasingly studied in human cancer therapy trials.</p>
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
ClinicalTrials.gov study NCT00791648. IPD Sharing: YES. Countries: 1. Publications: 3.
Automated, medication-targeted alerts for Acute Kidney Injury – A randomized trial
<p>Acute kidney injury is common among hospitalized individuals, particularly those exposed to certain medications, and is associated with substantial morbidity and mortality. In a pragmatic, open-label, parallel group randomized controlled trial (clinicaltrials.gov NCT02771977), we investigate whether an automated clinical decision support system affects discontinuation rates of potentially nephrotoxic medications and improves outcomes in patients with AKI. Participants included 5,060 hospitalized adults with AKI and an active order for any of three classes of medications of interest: non-steroidal anti-inflammatory drugs, renin-angiotensin-aldosterone system inhibitors, or proton pump inhibitors. Within 24 hours of randomization, a medication of interest was discontinued in 61.1% of the alert group versus 55.9% of the usual care group (relative risk 1.08, 1.04–1.14, p=0.0003). The primary outcome – a composite of progression of acute kidney injury, dialysis, or death – occurred in 585 (23.1%) individuals in the alert group and 639 (25.3%) patients in the usual care group (RR 0.92, 0.83–1.01, p=0.09). The pre-specified subgroup analysis found a significant benefit of alerting among those exposed to proton pump inhibitors but not non-steroidal anti-inflammatory drug or renin-angiotensin system inhibitor.</p>
PASS - A SCORING SYSTEM TO EVALUATE PERSISTENT ACUTE KIDNEY INJURY IN CRITICALLY ILL ADULT ICU PATIENTS
<p>Acute Kidney Injury (AKI) and sepsis is highly prevalent in Intensive Care Units (ICU) and has direct effect on mortality and morbidity. We aimed to evaluate if course and recovery of sepsis-AKI can be predicted using variables collected at the time of admission, and to develop a formula - Persistent AKI Scoring System (PASS) to predict recovery.</p> <p>63 consecutive patients admitted for sepsis-AKI in our ICUs were evaluated over a period of 8 months. Baseline demographic and clinical/laboratory parameters ,including serum creatinine (SCr), Base Excess (BE), Plethysmographic Variability Index (PVI), Caval Index, R wave Variability (RVI), Mean Arterial Pressure (MAP) and Renal Resistivity Index (RI) using renal doppler and need for inotropes were assessed on admission. Patients were managed with standard protocols with fluid resuscitation and other specific therapy. After 6 of hours of fluid resuscitation, hemodynamic status and volume status of the patient was assessed. Patients were classified as Volume Responders or Non-responders depending on hemodynamic stabilization using parameters like MAP. Re- assessment of all the variables was done at 24 hours and 72 hours after admission. The primary outcome was persistent AKI after 72hrs. The secondary outcome was initiation of dialysis and death within 15 days of admission.</p> <p>34 subjects recovered from AKI. 32 patients showed volume response with respect to hemodynamic parameters and 31 patients were non-responders. Response to fluid, MAP at admission, MAP after 6 hours, BE at admission, inotrope requirement, and PVI at admission did not correlate with recovery of AKI. RI, RVI and S Cr at admission significantly correlated with recovery from AKI These 3 parameters were evaluated further to develop the model for predicting recovery from AKI.• Score> 7.8 predicted recovery from AKI with sensitivity of 79.4%, specificity of 72.4%. PPV 81.8% and NPV 76.7%. PASS Score>7.8 had AUROC of 0.85.</p> <p>Multiple logistic regression showed that SCr< 2.36 mg%, RVI > 14.45 and RI < 0.8 on admission correlated with recovery.</p> <p>PASS SCORE Formula was created using the same.</p> <p>CONCLUSION: PASS score can be a simple bed side method to reliably identify salvageable cases of sepsis-AKI, guiding fluid resuscitation and also aiding early referrals from rural to higher centers for better management.</p>
Imaging dataset from: Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron
<div> <span><span>Acute kidney injury (AKI) is a risk factor for chronic kidney disease (CKD), but the cellular mechanisms leading to i</span><span>m</span><span>paired tubular recovery and </span><span>subsequent</span> <span>AKI-CKD-transition are not yet fully understood. In this study, we combined </span><span>transgenic mice to </span><span>monitor</span><span> proliferation in vivo, </span><span>a novel </span><span>injury </span><span>model of AKI, in which </span><span>ischemia</span></span><span><span>-</span></span><span><span>reperfusion injury </span><span>(IRI) was induced in half of the kidney (partial</span></span><span><span>-</span></span><span><span>IRI), and serial intravital 2-photon imaging via an </span><span>Abdominal I</span><span>maging </span><span>W</span><span>indow (AIW) to track tissue remodeling in post- and non-ischemic kidney regions longitudinally over 3 weeks. Our results and novel findings are presented in the associated pre-print "Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron".</span></span><span> </span> </div> <div> <span><span>In this dataset, we </span><span>provide</span><span> the imaging data which we </span><span>acquired</span><span> during the study.</span><span> Overall, the dataset consists of: #1: serial intravital imaging via 2-photon microscopy and genetic identification of proliferating cells in kidneys undergoing partial IRI; #2: serial intravital imaging via 2-photon microscopy and genetic identification of proliferating cells of control, uninjured kidneys; #3: intravital imaging of kidney epithelial cells during intravenous injection of a fluorescent bolus to determine the identity of tubular segments across the nephron; #4: intravital imaging of </span><span>and genetic identification of proliferating cells </span><span>after selective laser injury of </span><span>S1 </span><span>proximal tubule cells; #5 in vivo and ex-vivo imaging of kidney and kidney slices after VCAM1 staining. The data descriptors </span><span>provide</span><span> detailed guidelines on how to place individual imaging files in the context of the pathophysiological states used in the study.</span></span><span> </span> </div> <div> <span><span>Our goal is to </span><span>provide</span><span> an organize</span><span>d</span> <span>and accessible </span><span>unique and unprocessed </span><span>in vivo imaging dataset </span><span>that </span><span>documents </span></span><span><span>in vivo</span></span><span><span> tubule cell remodeling in </span><span>the mouse kidney </span></span><span><span>longitudinally and</span></span> <span><span>during </span><span>physiological and pathological conditions. Sharing </span><span>of </span><span>th</span><span>is</span><span> dataset </span><span>ensures</span><span> </span><span>reproducing</span><span> and expanding </span><span>of </span><span>our preclinical findings of </span><span>tubule injury and (failed)</span><span> recovery during AKI</span><span>. Furthermore, this dataset may also be </span><span>utilized</span> <span>for teaching purposes, as the combination of fluorescent imaging techniques allow</span><span>s</span><span> the </span><span>detail</span><span>ed</span><span> visualization of</span><span> kidney anatomy and physiology over multiple conditions.</span></span> </div>
Personalized Recommendations for Acute Kidney Injury (AKI) Care
ClinicalTrials.gov study NCT04040296. IPD Sharing: YES. Countries: 1. Publications: 3.
Remote Ischemic Preconditioning and Contrast Induced - Acute Kidney Injury in Patients Undergoing Elective PCI
ClinicalTrials.gov study NCT03761368. IPD Sharing: YES. Countries: 1. Publications: 1.
Effects of Intraoperative Fluid Therapy on Acute Kidney Injury After Thoracoscopic Lobectomy
ClinicalTrials.gov study NCT04302467. IPD Sharing: NO. Countries: 1. Publications: 2.
Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass
ClinicalTrials.gov study NCT01709227. IPD Sharing: YES. Countries: 1. Publications: 1.
Optimizing Electronic Alerts for Acute Kidney Injury
ClinicalTrials.gov study NCT02753751. IPD Sharing: YES. Countries: 1. Publications: 5.
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
ClinicalTrials.gov study NCT03534141. IPD Sharing: NO. Countries: 1. Publications: 6.
Protocol to Assess the Severity of Acute Kidney Injury
ClinicalTrials.gov study NCT00673244. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization
ClinicalTrials.gov study NCT04530448. IPD Sharing: NO. Countries: 1. Publications: 23.
Lowering Serum Uric Acid to Prevent Acute Kidney Injury
ClinicalTrials.gov study NCT00756964. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury
ClinicalTrials.gov study NCT01400893. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery
ClinicalTrials.gov study NCT00556491. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
ClinicalTrials.gov study NCT02568722. IPD Sharing: Not stated. Countries: 15. Publications: 8.
Is Levosimendan Superior to Milrinone Regarding Acute Kidney Injury After Cardiac Surgery for Congenital Heart Disease?
ClinicalTrials.gov study NCT02232399. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU
ClinicalTrials.gov study NCT04010630. IPD Sharing: YES. Countries: 1. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.