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13 results for “Admixture Mapping”
Рис. 1. Географическое поΛожение Норского заповеΑника (А) и картосхема распоΛожения на его территории (Б) учетных пΛощаΑок с фитоценозами (L_1–L_7) на Αвух мониторинговых станциях (I–II). I — МаΛьцевская: L_1 — березняк с участием осины и Λиственницы рябинниковый вейниково-разнотравный; L_2 — осиново-беΛоберезовый рябинниковый вейниково-разнотравный Λес; L_3 — Λиственничник с участием березы пΛоскоΛистной осоково-вейниковый с разнотравьем; L_4 — беΛоберезово-Λиственничный с примесью осины роΑоΑенΑроновый бруснично-осоковый Λес; L_5 — закустаренный, преимущественно тавоΛгой ивоΛистной, разнотравно-вейниковый Λуг. II — Антоновская: L_6 — Λиственничник роΑоΑенΑроново-брусничный; L_7 — Λиственнично-беΛоберезовый с примесью пихты и еΛи закустаренный разнотравно-вейниковый Λес (коΑ типа местообитания соответствуют таковому в табΛ. 1 и 3 и на рис. 2) Fig. 1. Geographical location of the Norsky Nature Reserve (A) and the map (B) of registration sites with phytocenoses (L_1–L_7) at two monitoring stations (I–II). I — Maltsevskaya: L_1 — birch forest with aspen and larch, fieldfare reed-forb; L_2 — aspen-white-birch, fieldfare reed-forb forest; L_3 — larch forest with flat-leaved sedge-reed birch with forbs; L_4 — white-birch-larch with an admixture of aspen rhododendron lingonberry-sedge forest; L_5 — bushy, mostly meadowsweet, forb-reed grass meadow. II — Antonovskaya: L_6 — rhododendron-cowberry larch forest; L_7 — larch-white-birch with fir and spruce, shrubby forb-reed grass forest (the code of the habitat type corresponds to that in Tables 1 and 3 and in Fig. 2) in Structure and dynamics of the taxocenes of shrews in different habitats of the Norsky nature reserve
Рис. 1. Географическое поΛожение Норского заповеΑника (А) и картосхема распоΛожения на его территории (Б) учетных пΛощаΑок с фитоценозами (L_1–L_7) на Αвух мониторинговых станциях (I–II). I — МаΛьцевская: L_1 — березняк с участием осины и Λиственницы рябинниковый вейниково-разнотравный; L_2 — осиново-беΛоберезовый рябинниковый вейниково-разнотравный Λес; L_3 — Λиственничник с участием березы пΛоскоΛистной осоково-вейниковый с разнотравьем; L_4 — беΛоберезово-Λиственничный с примесью осины роΑоΑенΑроновый бруснично-осоковый Λес; L_5 — закустаренный, преимущественно тавоΛгой ивоΛистной, разнотравно-вейниковый Λуг. II — Антоновская: L_6 — Λиственничник роΑоΑенΑроново-брусничный; L_7 — Λиственнично-беΛоберезовый с примесью пихты и еΛи закустаренный разнотравно-вейниковый Λес (коΑ типа местообитания соответствуют таковому в табΛ. 1 и 3 и на рис. 2) Fig. 1. Geographical location of the Norsky Nature Reserve (A) and the map (B) of registration sites with phytocenoses (L_1–L_7) at two monitoring stations (I–II). I — Maltsevskaya: L_1 — birch forest with aspen and larch, fieldfare reed-forb; L_2 — aspen-white-birch, fieldfare reed-forb forest; L_3 — larch forest with flat-leaved sedge-reed birch with forbs; L_4 — white-birch-larch with an admixture of aspen rhododendron lingonberry-sedge forest; L_5 — bushy, mostly meadowsweet, forb-reed grass meadow. II — Antonovskaya: L_6 — rhododendron-cowberry larch forest; L_7 — larch-white-birch with fir and spruce, shrubby forb-reed grass forest (the code of the habitat type corresponds to that in Tables 1 and 3 and in Fig. 2)
Data from: Admixture mapping reveals evidence for multiple mitonuclear incompatibilities in swordtail fish hybrids
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Data from: Admixture mapping of male nuptial color and body shape in a recently formed hybrid population of threespine stickleback
Despite recent progress, we still know relatively little about the genetic architecture that underlies adaptation to divergent environments. Determining whether the genetic architecture of phenotypic adaptation follows any predictable patterns requires data from a wide variety of species. However, in many organisms, genetic studies are hindered by the inability to perform genetic crosses in the laboratory or by long generation times. Admixture mapping is an approach that circumvents these issues by taking advantage of hybridization that occurs between populations or species in the wild. Here, we demonstrate the utility of admixture mapping in a naturally occurring hybrid population of threespine sticklebacks (Gasterosteus aculeatus) from Enos Lake, British Columbia. Until recently, this lake contained two species of sticklebacks adapted to divergent habitats within the lake. This benthic-limnetic species pair diverged in a number of phenotypes, including male nuptial coloration and body shape, which were previously shown to contribute to reproductive isolation between them. However, recent ecological disturbance has contributed to extensive hybridization between the species, and there is now a single, admixed population within Enos Lake. We collected over 500 males from Enos Lake and found that most had intermediate nuptial color and body shape. By genotyping males with nuptial color at the two extremes of the phenotypic distribution, we identified seven genomic regions on three chromosomes associated with divergence in male nuptial color. These genomic regions are also associated with variation in body shape, suggesting that tight linkage and/or pleiotropy facilitated adaptation to divergent environments in this benthic-limnetic species pairs.
Data from: Admixture mapping identifies introgressed genomic regions in North American canids
Hybrid zones typically contain novel gene combinations that can be tested by natural selection in a unique genetic context. Parental haplotypes that increase fitness can introgress beyond the hybrid zone, into the range of parental species. We used the Affymetrix canine SNP genotyping array to identify genomic regions tagged by multiple ancestry informative markers that are more frequent in an admixed population than expected. We surveyed a hybrid zone formed in the last 100 years as coyotes expanded their range into eastern North America. Concomitant with expansion, coyotes hybridized with wolves and some populations became more wolflike, such that coyotes in the northeast have the largest body size of any coyote population. Using a set of 3102 ancestry informative markers, we identified 60 differentially introgressed regions in 44 canines across this admixture zone. These regions are characterized by an excess of exogenous ancestry and, in northeastern coyotes, are enriched for genes affecting body size and skeletal proportions. Further, introgressed wolf-derived alleles have penetrated into Southern US coyote populations. Because no wolves currently exist in this area, these alleles are unlikely to have originated from recent hybridization. Instead, they probably originated from intraspecific gene flow or ancient admixture. We show that grey wolf and coyote admixture has far-reaching effects and, in addition to phenotypically transforming admixed populations, allows for the differential movement of alleles from different parental species to be tested in new genomic backgrounds.
Data from: Admixture mapping in a hybrid zone reveals loci associated with avian feather coloration
Identifying the genetic bases for color patterns has provided important insights into the control and expression of pigmentation and how these characteristics influence fitness. However, much more is known about the genetic bases for traits based on melanin pigments than for traits based on another major class of pigments, carotenoids. Here we use natural admixture in a hybrid zone between Audubon's and myrtle warblers (Setophaga coronata auduboni / S. c. coronata) to identify genomic regions associated with both types of pigmentation. Warblers are known for rapid speciation and dramatic differences in plumage. For each of five plumage coloration traits, we found highly significant associations with multiple SNPs across the genome and these were clustered in discrete regions. Regions near significantly associated SNPs were enriched for genes associated with keratin filaments, fibrils that makeup feathers. A carotenoid-based trait that differs between the taxa—throat color—had more than a dozen genomic regions of association. One cluster of SNPs for this trait overlaps the Scavenger Receptor Class F Member 2 (SCARF2) gene. Other scavenger receptors are presumed to be expressed at target tissues and involved in the selective movement of carotenoids into the target cells, making SCARF2 a plausible new candidate for carotenoid processing. In addition, two melanin-based plumage traits—colors of the eye line and eye spot—show very strong associations with a single genomic region mapping to chromosome 20 in the zebra finch. These findings indicate that only a subset of the genomic regions differentiated between these two warblers are associated with the plumage differences between them and demonstrate the utility of reduced-representation genomic scans in hybrid zones.
Data from: Admixture mapping of quantitative traits in Populus hybrid zones: power and limitations
Uncovering the genetic architecture of species differences is of central importance for understanding the origin and maintenance of biological diversity. Admixture mapping can be used to identify the number and effect sizes of genes that contribute to the divergence of ecologically important traits, even in taxa that are not amenable to laboratory crosses due to their long generation time or other limitations. Here, we apply admixture mapping to naturally occurring hybrids between two ecologically divergent Populus species. We map quantitative trait loci (QTL) for eight leaf morphological traits using 77 mapped microsatellite markers from all 19 chromosomes of Populus. We apply multivariate linear regression analysis allowing the modeling of additive and non-additive gene action and identify several candidate genomic regions associated with leaf morphology using an information-theoretic approach. We perform simulation studies to assess the power and limitations of admixture mapping of quantitative traits in natural hybrid populations for a variety of genetic architectures and modes of gene action. Our results indicate that (1) admixture mapping has considerable power to identify the genetic architecture of species differences if sample sizes and marker densities are sufficiently high, (2) modeling of non-additive gene action can help to elucidate the discrepancy between genotype and phenotype sometimes seen in interspecific hybrids, and (3) the genetic architecture of leaf morphological traits in the studied Populus species involves complementary and overdominant gene action, providing the basis for rapid adaptation of these ecologically important forest trees.
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
ClinicalTrials.gov study NCT00559767. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes
ClinicalTrials.gov study NCT00726778. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Admixture mapping identifies introgressed genomic regions in North American canids
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Data from: Admixture mapping of quantitative traits in Populus hybrid zones: power and limitations
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Data from: Admixture mapping in a hybrid zone reveals loci associated with avian feather coloration
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Data from: Admixture mapping of male nuptial color and body shape in a recently formed hybrid population of threespine stickleback
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Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal
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