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256 results for “Aedes aegypti”
Asaia spp. accelerate development of the yellow fever mosquito, Aedes aegypti, via interactions with the vertically transmitted larval microbiome
<p><strong><span>Background:</span></strong><em> Aedes aegypti</em> mosquitoes are the primary vectors of yellow fever, dengue, chikungunya and Zika virus. Control programs primarily rely on insecticide application, which encounter challenges related to efficacy and resistance evolution. Alternative strategies, such as the sterile insect technique, highly depend on efficient mass-rearing of healthy insects prior to mass release. Based on effects seen in other mosquito species, we tested the hypothesis that acetic acid bacteria <span>of the </span><em>Asaia</em> <span>genus are</span> mutualist<span>s</span> for developing <em>Ae. aegypti</em> larvae. We tested for beneficial interactions across three <em>Asaia </em>species and whether <em>Asaia</em> inoculation benefited both axenic and conventionally reared larvae. To better understand the underlying mechanisms, we characterized the larval microbiome<span> </span>using culture-based methods and 16S rRNA gene amplicon sequencing.</p> <p><strong>Results:</strong><span> <span>Even</span></span> though <em>Asaia </em>bacteria were transient members of the gut community in conventionally reared insects<span>, t</span>wo <em>Asaia </em>species accelerated larval development relative to controls.<span> Despite their transient nature, </span>the two mutualist <em>Asaia</em> species had lasting impacts on the larval microbiome, mostly by altering the relative abundance of the most dominant bacteria genera <em>Klebsiella</em> and <em>Pseudomonas</em> and other minor components<span>.</span> Axenic larvae that were inoculated with <em>Asaia </em>were dominated by this group, but always exhibited slower development than conventionally reared insects.</p> <p><strong>Conclusions:</strong> These results reveal <em>Asaia</em> as a poor mutualist for <em>Ae. aegypti</em>, with its<em> </em>positive effect on the host mediated by interactions with other bacteria. A practical application of <em>Asaia </em>for improving mass-rearing efficiency results from the acceleration of development time to pupation by a day.</p>
Venkataraman et al. Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought
<p>VERSION 1: These supplementary files accompany the manuscript by Venkataraman et al. entitled "Rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought." This includes all raw data in the paper, supplementary data, and instructions for the blood puck feeder.</p> <p>VERSION 2: Supplemental Data Files 16-20 were added on 12/19/2022 to accompany a revision of the original bioRxiv pre-print after peer-review at eLife.</p> <p>VERSION 3: New versions of all files were added on 3/21/2023 to accompany the version of record published in eLife:</p> <p>Krithika Venkataraman , Nadav Shai, Priyanka Lakhiani, Sarah Zylka, Jieqing Zhao, Margaret Herre, Joshua Zeng, Lauren A Neal, Henrik Molina, Li Zhao, Leslie B Vosshall. Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought. Elife. 2023 Feb 6;12:e80489. PMID: 36744865 DOI: 10.7554/eLife.80489</p>
Data from: Blockade of dengue virus transmission from viremic blood to Aedes aegypti mosquitoes using human monoclonal antibodies
Background <p class="CxSpFirst">Dengue is the most prevalent arboviral disease of humans. Virus neutralizing antibodies are likely to be critical for clinical immunity after vaccination or natural infection. A number of human monoclonal antibodies (mAbs) have previously been characterized as able to neutralize the infectivity of dengue virus (DENV) for mammalian cells in cell-culture systems.</p> <p class="CxSpLast"> </p> Methodology/Principle findings <p class="CxSpFirst">We tested the capacity of 12 human mAbs, each of which had previously been shown to neutralize DENV in cell-culture systems, to abrogate the infectiousness of dengue patient viremic blood for mosquitoes. Seven of the twelve mAbs (1F4, 14c10, 2D22, 1L12, 5J7, 747(4)B7, 753(3)C10), almost all of which target quaternary epitopes, inhibited DENV infection of <i>Ae. aegypti</i>. The mAbs 14c10, 747(4)B7 and 753(3)C10 could all inhibit transmission of DENV in low microgram per mL concentrations. An Fc-disabled variant of 14c10 was as potent as its parent mAb.</p> <p class="CxSpLast"> </p> Conclusions/Significance <p class="CxSpFirst">The results demonstrate that mAbs can neutralize infectious DENV derived from infected human cells, in the matrix of human blood. Coupled with previous evidence of their ability to prevent DENV infection of mammalian cells, such mAbs could be considered attractive antibody classes to elicit with dengue vaccines, or alternatively, for consideration as therapeutic candidates.</p>
Fig. 2. A in Genetic differentiation in populations of Aedes aegypti (Diptera, Culicidae) dengue vector from the Brazilian state of Maranhão
Fig. 2. A priori estimate of the probable groups of populations produced by the BAPS (Bayesian Analysis of Population Structure v 6.0) program, indicating a total of two groups.
Thermal adaptation in Aedes aegypti does not constrain temperature-sensitive growth of bacteria or dengue virus
<p>Data set and R script used for the following manuscript : </p> <p><strong>Thermal adaptation in <em>Aedes aegypti</em> does not constrain temperature-sensitive growth of bacteria or dengue virus</strong></p> <p><span lang="EN-US">Alida Kropf<sup>1*#</sup>, Stéphanie Dabo<sup>2</sup>, Marine Amann<sup>3</sup>, Louis Lambrechts<sup>2</sup>, Jacob C Koella<sup>1</sup></span></p> <p><span lang="EN-US">PROCEEDINGS OF THE ROYAL SOCIETY B THE ROYAL SOCIETY B BIOLOGICAL SCIENCES</span></p> <p><strong><em><span lang="IT-CH">DOI: 10.1098/rspb.2025-0832.R1 </span></em></strong></p>
Carbon dioxide and blood-feeding shift visual cue tracking during navigation in Aedes aegypti mosquitoes
<p>Hematophagous mosquitoes need a blood meal to complete their reproductive cycle. To accomplish this, female mosquitoes seek vertebrate hosts, land on them, and bite. As their eggs mature, they shift attention away from hosts and towards finding sites to lay eggs. We asked whether females were more tuned to visual cues when a host-related signal, carbon dioxide, was present, and further examined the effect of a blood meal, which shifts behavior to ovipositing. Using a custom, tethered-flight arena that records wing stroke changes while displaying visual cues, we found the presence of CO2 enhances visual attention towards discrete stimuli and improves contrast sensitivity for host-seeking <em>Aedes aegypti</em> mosquitoes. Conversely, intake of a blood meal reverses vertical bar tracking, a stimulus that non-fed females readily follow. This switch in behavior suggests that physiological status modulates visual attention in mosquitoes, a phenomenon that has been described before in olfaction but not in visually-driven behaviors.</p>
Fig. 1 in Long-term exposure of Aedes aegypti to Bacillus thuringiensis svar. israelensis did not involve altered susceptibility to this microbial larvicide or to other control agents
Fig. 1 Resistance ratios (RR) betseen the lethal concentrations of Bti and its toxins (Cru11Aa, Cru4Ba), temephos (Tem) and diflubenzuron (Dif) for third-instar Ae. aegypti larvae from the RecBti strain compared to that of the reference strain. a RR at LC50. b RR at LC90
Fig. 1 in Neem oil increases the efficiency of the entomopathogenic fungus Metarhizium anisopliae for the control of Aedes aegypti (Diptera: Culicidae) larvae
Fig. 1 Dacls survcval curves of Aedes aegypti larvae exposed to dcfferent concentratcons of neem ocl. Note: Results are the means (± SE) of three expercments for each treatment wcth 30 cnsects used per treatment for each expercment
Fig. 2 in Neem oil increases the efficiency of the entomopathogenic fungus Metarhizium anisopliae for the control of Aedes aegypti (Diptera: Culicidae) larvae
Fig. 2 Dacls survcval curves of Aedes aegypti larvae exposed to dcfferent concentratcons of Metarhizium anisopliae concdca. Note: Results are the means (± SE) of three expercments for each treatment wcth 30 cnsects used per treatment for each expercment
Figure 2 in Toxicity and larvicidal activity on Aedes aegypti of citronella essential oil submitted to enzymatic esterification
Figure 2. Mortality percentage of Artemia salina nauplii in relation to increased sample concentration.
Figure 1 in Toxicity and larvicidal activity on Aedes aegypti of citronella essential oil submitted to enzymatic esterification
Figure 1. Kinetics of citronellyl and geranyl cinnamates production (molar ratio alcohol/acid 3:1, enzyme 15 wt%, temperature 70°C, 150 rpm).
Fig. 1 in First report of kdr mutations in the voltage-gated sodium channel gene in the arbovirus vector, Aedes aegypti, from Nouakchott, Mauritania
Fig. 1 The combinations of kdr point mutations S989P, V1016G, and F1534C in adult female Aedes aegypti mosquitoes in Nouakchott, Mauritania
Figure 3 in Late effects of Beauveria bassiana on larval stages of Aedes aegypti Linneo, 1762 (Diptera: Culicidae)
Figure 3. Biological cycle of Ae. aegypti, phase to phase time contrast in the survivors of the tested strains and the daily cycle according to the literature under laboratory conditions [25 ± 2 ° C; 12:12 h (light: darkness)].
Figure 2 in Late effects of Beauveria bassiana on larval stages of Aedes aegypti Linneo, 1762 (Diptera: Culicidae)
Figure 2. Mortality of Aedes aegypti larvae by conidia of Beauveria bassiana (NB3 and GHA strain) in different development phase under laboratory conditions [25 ± 2 ° C; 12:12 h (light: darkness). Treatments with different letters are significantly different (p≤0.05).
Fig. 1 in Mosquito fauna associated with Aedes aegypti (Diptera: Culicidae) in Yucatán State of southeastern México, and checklist with new records
Fig. 1. Geographical distribution of mosquito species from Yucatán State surveyed during Jul 2014 to Dec 2015.
Figure 1 in Gene Flow Patterns of the Aedes aegypti (Diptera: Culicidae) Mosquito in Colombia: a Continental Comparison Suggests Multiple Invasion Routes and Gene Exchange
Figure 1 Geographic location of the A. aegypti populations included in this study and gene-flow models evaluated. In both graphics, circles indicate the populations and arrows represent the gene flow between populations. A) Scale at American continent level (N = 2,996 specimens from six locations: Mexico – North America (M-NA), Venezuela (VZ), Peru (PE), Brazilian Amazon (BrAm), southeastern Brazil (SEBr), and Colombia (CO). B) Scale at South America level (N = 1,083 specimens from six locations: Venezuela, Peru, Brazilian Amazon (5 locations; Brazilian Amazon (BrAM), Manaus (MAO), Belém (BL). Boa Vista (BV), Rio Branco (RB), Porto Velho (PV)), Southeastern Brazil (SEBr) and Colombia (2 locations; Sucre (S), Quindio (Q)).
Figure 4. Phylogeny constructed through Bayesian inference estimated from the 35H in Gene Flow Patterns of the Aedes aegypti (Diptera: Culicidae) Mosquito in Colombia: a Continental Comparison Suggests Multiple Invasion Routes and Gene Exchange
Figure 4. Phylogeny constructed through Bayesian inference estimated from the 35H found of the ND4 gene for the A. aegypti populations in the American continent. The blue horizontal bars above the branches reflect the 95% CI for the branch supports. The color bars (blue, green, and red) on the tree terminals indicate which haplotypes are exclusive for a specific population. The dotted lines on the right side of the tree and numbers I or II indicate to what clade each of the terminals belong. H1-Col (Colombia (Sucre and Quindio), Venezuela, Peru, M-NA, Brasil (MA-O, RBPV, SEBr, BE-L)), H4 (Venezuela, M-NA, Brasil (MA-O, RBPV, BEL)), H3 (Venezuela, M-NA, Brazil (RBPV, SEBr, BE-L)), H2-Col (Colombia (Sucre), Venezuela, Peru, M-NA, Brazil (RBPV, SEBr, BE-L)), H13 (M-NA, Brazil (SEBr)), H8 (Venezuela, Brazil (SEBr)).
Figure 3 in Gene Flow Patterns of the Aedes aegypti (Diptera: Culicidae) Mosquito in Colombia: a Continental Comparison Suggests Multiple Invasion Routes and Gene Exchange
Figure 3. Representation of the gene-flow model with greater subsequent probability in the scenarios of the Americas and South America.A. Scale at American continent level (N = 2,996 specimens from six locations: Mexico–North America, Venezuela, Peru, Brazilian Amazon, southeastern Brazil, and Colombia. Within the continent context, the Stepping Stone 1 model shows through the green vectors the way the gene flow occurs among the different populations evaluated. B. Scale at South America level; the Full-migration model indicates migration among all the populations, hence, plotting of the potential migration routes through passive land transport (Pan-American highway) and riverine paths (principal rivers).
Figure 2 in Molecular tool for monitoring the safety of Aedes (Stegomyia) aegypti Rockefeller rearing in arthropod containment facilities
Figure 2 Single Nucleotide Polymorphisms sites distribution in Aedes aegypti haplotypes according to the ND5 molecular marker. A) Phylogenetic estimation using the UPGMA method. Aa Rock 1 to 22, A. aegypti Rockefeller sequences obtained from 22 laboratory-bred Rock strain individuals. Aa, A. aegypti sequences obtained from towns located in the southeast of Buenos Aires Province (Lezama (LEZ), Castelli (CAS), Dolores (DOL), San Clemente del Tuyú (SC), Chascomús (CHA), La Plata City (LP) and from Buenos Aires City (BA). H1 to H14, 14 haplotypes reported by Albrieu Llinás and Gardenal (2012) and Díaz-Nieto et al. (2016) Rock contig 1 to 14, Illumina-contigs (A. aegypti Rock_Contig 1 to 14). Aa LVP, sequence from mitochondrial genome of A. aegypti Liverpool strain (LVP_AGWG). LVPib, A. aegypti inbred sub-strain LVPib12 according to Table 1. B) Its distribution along South America. The map was drawn from free maps of the website of the National Geographic Institute http://www.ign.gob.ar/AreaServicios/Descargas/MapasEscolares. The areas on the map were colored using Adobe Illustrator CS6 program.
Figure 4 in Geometric morphometrics of Aedes aegypti populations and study of transmission of arboviral diseases in Barreiras, Brazil
Figure 4 Graphical representation of wing shape comparison of different areas.(A) Diagrams of first canonical variable from the comparison (discriminant analysis) between A and B areas (considering the highway as a barrier). (B) Diagrams of first canonical variable from the comparison between A and C areas (considering the river as a barrier). (C) Diagrams of first canonical variable of the comparison between B and C areas (considering both, the highway and the river as barriers).
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