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Dataset results
58 results for “Agonist antibody”
A novel TNFR2 agonist antibody expands highly potent regulatory T cells
<p>Regulatory T cells (T<sub>reg</sub> cells) restrict immune system activity, such as in response to self-antigens, and are switched on by tumor necrosis factor receptor 2 (TNFR2). Therapeutic activation of TNFR2, thereby expanding T<sub>reg</sub> cells and suppressing immune activity, may be beneficial to patients with various inflammatory diseases. Here, we characterized a new human TNFR2-directed antibody agonist isolated from mice. We found that the antibody agonist expanded the number of T<sub>reg</sub> cells within cultures of primary human CD4<sup>+</sup> T cells from healthy donors and patients with type 1 diabetes or Sézary syndrome. These T<sub>reg</sub> cells had increased metabolic gene expression and intracellular itaconate concentrations, characteristics associated with maximally suppressive, anti-inflammatory T<sub>reg</sub> cells. Furthermore, antibody-expanded T<sub>reg</sub> cells repressed the activity of primary human CD8<sup>+</sup> effector T cells (T<sub>eff</sub> cells). Epitope mapping suggested that the antibody bound to TNFR2 through a natural cross-linking surface and that T<sub>reg</sub> cell expansion was independent of the antibody Fc region. In addition, T<sub>reg</sub> cell expansion was not increased by adding either supplemental TNF ligand or a cross-linking reagent, suggesting that the antibody agonist by itself can elicit maximal activity, a notion that was confirmed by increased secretion of soluble TNFR2. Pending in vivo tests, these features indicate that this TNFR2 antibody agonist has the potential to safely and effectively treat various inflammatory disorders.</p>
TLR9 Agonist SD-101, Anti-OX40 Antibody BMS 986178, and Radiation Therapy in Treating Patients With Low-Grade B-Cell Non-Hodgkin Lymphomas
ClinicalTrials.gov study NCT03410901. IPD Sharing: NO. Countries: 1. Publications: 2.
A novel TNFR2 agonist antibody expands highly potent regulatory T cells
Open the record for dataset details and reuse information.
Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy
ClinicalTrials.gov study NCT04159415. IPD Sharing: YES. Countries: 4. Publications: 0.
FLT3 Ligand, CD40 Agonist Antibody, and Stereotactic Radiotherapy
ClinicalTrials.gov study NCT04491084. IPD Sharing: Not stated. Countries: 1. Publications: 0.
4-1BB Agonist Monoclonal Antibody PF-05082566 With Trastuzumab Emtansine or Trastuzumab in Treating Patients With Advanced HER2-Positive Breast Cancer
ClinicalTrials.gov study NCT03364348. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
ClinicalTrials.gov study NCT05088460. IPD Sharing: YES. Countries: 4. Publications: 0.
CD40 Agonistic Antibody APX005M (Sotigalimab) in Combination With Nivolumab
ClinicalTrials.gov study NCT03123783. IPD Sharing: NO. Countries: 2. Publications: 0.
SIRPa agonist antibody treatment ameliorates experimental arthritis and colitis
GEO Series GSE236928. Homo sapiens; Mus musculus. 144 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
Rational derivation of midbrain dopamine neuron progenitors from hPSCs using a selective FZD5 antibody agonist [scRNA-Seq]
GEO Series GSE241042. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Rational derivation of midbrain dopamine neuron progenitors from hPSCs using a selective FZD5 antibody agonist [RNA-Seq]
GEO Series GSE241041. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
An agonistic anti-CD137 antibody promotes inflammatory signatures in immune cells that disrupt germinal center formation and T cell-dependent antibody responses
GEO Series GSE141111. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Responses to TREM2 Agonist Antibody Treatment in Cynomologus Monkey Brain [single nuclei RNA sequencing]
GEO Series GSE241190. Macaca fascicularis. 16 samples. Type: Expression profiling by high throughput sequencing.
Expression data of human Tregs treated with TNFR2 agonist antibody
GEO Series GSE185145. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
An agonistic anti-CD137 antibody promotes inflammatory signatures in immune cells that disrupt germinal center formation and T cell-dependent antibody responses II
GEO Series GSE141117. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
ABBV-319: A First-In-Class CD19-targeting Glucocorticoid Receptor Modulator (GRM) Agonist Antibody-Drug Conjugate (ADC) for the Treatment of B-cell Malignancies [RNA-seq]
GEO Series GSE249023. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Rational derivation of midbrain dopamine neuron progenitors from hPSCs using a selective FZD5 antibody agonist
GEO Series GSE241043. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Fc-optimized CD40 Agonistic Antibody Induces Tertiary Lymphoid Structures and Systemic Antitumor Immunity in Metastatic Cancer Patients [Human]
GEO Series GSE298047. Homo sapiens. 48 samples. Type: Other; Expression profiling by high throughput sequencing.
Single-cell RNA-seq data of human Tregs treated with TNFR2 agonist antibody
GEO Series GSE185144. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Expression data of iPS microglia treated with TREM2 agonist antibody
GEO Series GSE159333. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.