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ShareScore release 0.9.0
Dataset results
269 results for “Aldosterone”
Aldosterone and Glucose Homeostasis
ClinicalTrials.gov study NCT00732160. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy
ClinicalTrials.gov study NCT02354352. IPD Sharing: NO. Countries: 1. Publications: 1.
The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
ClinicalTrials.gov study NCT01996449. IPD Sharing: Not stated. Countries: 1. Publications: 7.
The Renin-Angiotensin-Aldosterone System and Parathyroid Hormone Control: The RAAS-PARC Study
ClinicalTrials.gov study NCT01691781. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)
ClinicalTrials.gov study NCT00141778. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3
ClinicalTrials.gov study NCT00685945. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
ClinicalTrials.gov study NCT06569589. IPD Sharing: YES. Countries: 1. Publications: 3.
Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function
ClinicalTrials.gov study NCT00094302. IPD Sharing: Not stated. Countries: 6. Publications: 75.
Effect of Aldosterone on Energy Starvation in Heart Failure
ClinicalTrials.gov study NCT00574119. IPD Sharing: NO. Countries: 1. Publications: 5.
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
ClinicalTrials.gov study NCT01173029. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Aldosterone and the Metabolic Syndrome
ClinicalTrials.gov study NCT01103245. IPD Sharing: NO. Countries: 1. Publications: 1.
Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease
ClinicalTrials.gov study NCT01129557. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Overnight Dexamethasone in Primary Aldosteronism Screening
ClinicalTrials.gov study NCT06740838. IPD Sharing: NO. Countries: 1. Publications: 19.
A Study of CIN-107 in Adults With Primary Aldosteronism
ClinicalTrials.gov study NCT04605549. IPD Sharing: YES. Countries: 1. Publications: 1.
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
ClinicalTrials.gov study NCT00962949. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Steroids-Based Screening for Primary Aldosteronism
ClinicalTrials.gov study NCT06941116. IPD Sharing: NO. Countries: 1. Publications: 15.
Diagnostic Accuracy of Adrenal Imaging for Subtype Diagnosis in Primary Aldosteronism: Systematic Review and Meta-Analysis
<p>Objectives: Accurate subtype classification in primary aldosteronism (PA) is critical in assessing the optimal treatment options. This study aimed to evaluate the diagnostic accuracy of adrenal imaging for unilateral PA classification.</p> <p>Methods: Systematic searches of PubMed, EMBASE, and the Cochrane databases were performed from January 1, 2000, to February 1, 2020, for all studies that used computed tomography (CT) or magnetic resonance imaging (MRI) in determining unilateral PA and validated the results against invasive adrenal vein sampling (AVS). Summary diagnostic accuracies were assessed using a bivariate random-effects model. Subgroup analyses, meta-regression and sensitivity analysis were performed to explore the possible sources of heterogeneity.</p> <p>Result: A total of 25 studies, involving a total of 4669 subjects, were identified. The overall analysis revealed a pooled sensitivity of 68% (95% confidence interval [CI]: 61 to 74) and specificity of 57% (95% CI: 50 to 65) for CT/MRI in identifying unilateral PA. Sensitivity was higher in the contrast-enhanced (CT) group versus the traditional CT group [77% (95% CI: 66 to 85) vs. 58% (95% CI: 50 to 66)]. Subgroup analysis stratified by screening test for PA showed that the sensitivity of the aldosterone-to-renin ratio (ARR) group was higher than that of the non-ARR group [78% (95% CI: 69 to 84) vs. 66% (95% CI: 58 to 72)]. The diagnostic accuracy of PA patients aged ≤40 years was reported in 4 studies, and the overall sensitivity was 71%, with 79% specificity. Meta-regression revealed a significant impact of sample size on sensitivity and of age and study quality on specificity.</p> <p>Conclusion: CT/MRI is not a reliable alternative to invasive AVS without excellent sensitivity or specificity for correctly identifying unilateral PA. Even in young patients (≤40 years), 21% of patients would have undergone unnecessary adrenalectomy based on imaging results alone.</p>
Data from: Aldosterone reduction rate after saline infusion may be a novel clinical prediction of determining subtypes of primary aldosteronism
<p><span><span><span><span><span><span><span><span><span><span><span><b>Objective</b>Accurate assessment of the localization of aldosterone-producing adenomas (APAs) is essential for the treatment of primary aldosteronism (PA). Although adrenal venous sampling (AVS) is the standard method of reference for subtype diagnosis in PA, controversy exists concerning the criteria for interpretation. This study aimed to determine better indicators that can reliably predict subtypes of PA. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Method</b>Retrospective analysis in single-cohort including 209 patients with PA who were subjected to AVS. 82 patients whose plasma aldosterone concentrations (PAC) were normalized after surgery were histopathologically or genetically diagnosed with APA. The accuracy of image findings was compared to AVS results. Receiver operating characteristic (ROC) curve analysis between the operated and no apparent laterality groups was performed using AVS parameters and loading test for diagnosis of PA. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Result </b>The agreement between image findings and AVS results was 56.3%. ROC curve analysis revealed that lateralization index (LI) after ACTH stimulation cutoff value was 2.40, with 98.8% sensitivity and 97.1% specificity. The contralateral suppression index (CSI) cutoff value was 1.19, with 98.0% sensitivity and 93.9% specificity. All patients over the LI and CSI cutoff values exhibited unilateral subtypes. Among the loading test, <span><span>the best classification accuracy was achieved using the </span></span>PAC reduction rate after saline infusion<span><span>test (SIT) >33.8%, which yielded 87.2% sensitivity or PAC after SIT <87.9 pg/mL 86.2% specificity for predicting bilateral PA. </span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Conclusion</b>The combined criterion of the PAC reduction rate and PAC after SIT may determine a subset of patients with APA who should be performed AVS for validation. </span></span></span></span></span></span></span></span></span></span></span></p> <p><br> </p>
Data for "The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor"
<p>This deposit contains all the single-molecule trajectories reported in "The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor".</p> <p>To access the tracks, open the mat file in MATLAB. This contains a MATLAB table with the following fields:</p> <p><strong>summary_table.cell_protein{i}</strong> identifies the i<sup>th</sup> dataset i.e. cell line + protein + treatment.</p> <p><strong>summary_table.X{i}{j}</strong> is an Nx2 array of x and y coordinates (in microns) for track j in condition i. N is the number of localizations in that track.</p> <p>Time interval between localizations is 200 ms.</p> <p>Details on data acquisition and tracking parameters can be found in the associated manuscript.</p>
Aldosterone and dexamethasone activate African lungfish mineralocorticoid receptor: Increased activation after removal of the amino-terminal domain
<p><span><span><span><span><span><span><span><span><span><span><span>Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by vertebrates. We studied transcriptional activation of the slender African lungfish MR by aldosterone, other corticosteroids and progesterone and find that aldosterone, 11-deoxycorticosterone, 11-deoxycortisol and progesterone have half-maximal responses (EC50s) below 1 nM and are potential physiological mineralocorticoids. In contrast, EC50s for corticosterone and cortisol were 23 nM and 66 nM, respectively. Unexpectedly, truncated lungfish MR, consisting of the DNA-binding, hinge and steroid-binding domains, had a stronger response to corticosteroids and progesterone than full-length lungfish MR, indicating that the N-terminal domain represses steroid activation of lungfish MR, unlike human MR in which the N-terminal domain contains an activation function. BLAST searches of GenBank did not retrieve a GR ortholog, leading us to test dexamethasone and triamcinolone for activation of lungfish MR. At 10 nM, both synthetic glucocorticoids are about 4-fold stronger than 10 nM aldosterone in activating full-length lungfish MR, leading us to propose that lungfish MR also functions as a GR.</span></span></span></span></span></span></span></span></span></span></span></p>
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Allen Brain Atlas
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OpenNeuro
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