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2,211 results for “Analgesia”
Functional Connectivity of Music-Induced Analgesia in Fibromyalgia
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Distinct brain networks involved in placebo analgesia between individuals with or without prior experience with opioids
<p><strong>ABSTACT</strong></p> <p>Placebo analgesia is defined as a psychobiological phenomenon triggered by the information surrounding an antalgic drug instead of its inherent pharmacological properties. Placebo analgesia is hypothesized to be formed through either verbal suggestions or conditioning. The present study aims at disentangling the neural correlates of expectations effects with or without conditioning through prior experience using the model of placebo analgesia.</p> <p>We will address this question by recruiting two groups of individuals holding comparable verbally-induced expectations regarding morphine analgesia but either (i) with or (ii) without prior experience with opioids. We will then contrast the two groups’ neurocognitive response to acute heat-pain induction following the injection of sham morphine using electroencephalography (EEG). Topographic ERP analyses of the N2 and P2 pain evoked potential components will allow to test the hypothesis that placebo analgesia involves distinct neural networks when induced by expectations with or without prior experience.</p>
Corticothalamic communication under analgesia, sedation and gradual ischemia: a multimodal model of controlled gradual cerebral ischemia in pig
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Dataset of The Relationship Between Postoperative Opioid Analgesia and Sleep Apnea Severity in Patients Undergoing Hip Arthroplasty: A Randomized, Controlled, Triple-Blinded Trial
<p>This the dataset related to the article entitled "he Relationship Between Postoperative Opioid Analgesia and Sleep Apnea Severity in Patients Undergoing Hip Arthroplasty: A Randomized, Controlled, Triple-Blinded Trial".</p> <p>Purpose: Residual postoperative pain after hip arthroplasty is usually treated with oral opioids. While classic opioids are associated with respiratory depression and worsening of sleep apnea, tramadol has been reported to preserve respiratory function. However, this has not been investigated in a prospective trial using respiratory polygraphy. This randomized controlled triple-blinded trial tested the hypothesis that postoperative treatment with oral opioids such as oxycodone would increase sleep apnea severity, measured with a respiratory polygraphy, compared with oral tramadol.<br> Patients and Methods: Sixty patients undergoing hip arthroplasty under spinal anesthesia with 15 mg isobaric bupivacaine 0.5% were randomized to receive postoperative pain treatment with either oral oxycodone (controlled-release 10 mg every 12 hours and immediate-release 5 mg every 4 hours as needed) or oral tramadol (controlled-release 100 mg every 8 hours and immediate-release 50 mg every 4 hours as needed). Respiratory polygraphy was performed on the first postoperative night. The primary outcome was the apnea-hypopnea index in the supine position. Secondary outcomes included the oxygen desaturation index, postoperative pain scores and intravenous morphine consumption.<br> Results: Mean supine apnea-hypopnea index on postoperative night 1 was 11.3 events.h−1 (95% confidence interval, 4.8–17.7) in the oxycodone group and 10.7 (4.6–16.8) events.h−1 in the tramadol group (p=0.89). There were no significant differences between the oxycodone and tramadol groups with respect to any secondary sleep-related or pain-related outcomes.<br> Conclusion: Oral oxycodone did not increase sleep apnea severity measured using respiratory polygraphy compared with oral tramadol on the first postoperative night after hip arthroplasty.</p>
Mapping the neuroethological signatures of pain, analgesia and recovery in mice
<p><strong>Mapping the neuroethological signatures of pain, analgesia and recovery in mice.</strong><br> Repository containing datasets obtained for M. Bohic, L Pattison, et al. 2023. Neuron. </p> <p><strong>Abstract</strong><br> Ongoing pain is driven by direct activation of pain-sensing neurons and neuroimmune mediated sensitization. These heightened pain states alter physiology, reduce motor function, and affect motivation to engage in normal behaviors. The complexity of the pain state has evaded a comprehensive definition, especially in nonverbal animals. Here in mice, we capture the physiological state of sensitized neurons and use computational tools to automatically map behavioral signatures of evoked and spontaneous displays of pain at different time points for both an acute model of paw inflammatory pain and a chronic model of knee joint pain. First, retrograde labeling coupled with electrophysiology of neurons innervating injury sites revealed key time points corresponding to peripheral sensitivity in multiple pain models. Next, we used high-speed videography combined with supervised and unsupervised machine learning tools to uncover sensory-evoked defensive coping postures, unique to each pain condition. Using 3D pose analytics inspired by natural language processing, we identify movement sequences that correspond to robust representations of ongoing pain states. With this new analytical framework, we find that commonly used analgesics do not return an animal’s behavior to a pre-injury state. Instead, animals adopt a novel set of spontaneous behaviors that are maintained even after most evoked behavioral features of pain have resolved. Together, these findings reveal previously unidentified neuroethological signatures of pain and analgesia at timescales when inflammation induces heightened pain states and during recovery.</p>
Non-opioids for Analgesia After Adenotonsillectomy in Children
ClinicalTrials.gov study NCT03618823. IPD Sharing: YES. Countries: 1. Publications: 11.
Figure S1 Surgical extraction of supernumerary teeth under sedation and analgesia, and a periapical radiograph 2 weeks later.
<p>Figure S1 Surgical extraction of supernumerary teeth under sedation and analgesia, and a periapical radiograph 2 weeks later.</p>
DataSet: Framing side effects positively: a way to enhance analgesia?
<p>Side effects are frequent in pharmacological pain management, potentially preceding analgesia and limiting drug tolerability. Discussing side effects is part of informed consent, yet can favor nocebo effects. This study aimed to test whether a positive suggestion regarding side effects, which could act as reminders of the medication having been absorbed, might favor analgesia in a clinical interaction model.</p> <p> </p> <p>Sixty-six healthy males participated in a study “to validate pupillometry as an objective measure of analgesia”. Participants were unknowingly randomized double-blind to positive vs control information about side effects embedded in a video regarding the study drugs. Sequences of moderately painful heat stimuli applied before and after treatment with diclofenac and atropine served to evaluate analgesia. Atropine was deceptively presented as a co-analgesic, but used to induce side effects. Adverse events (AE) were collected with the General Assessment of Side Effects (GASE) questionnaire prior to the second induced pain sequence. Debriefing fully informed participants regarding the purpose of the study and showed them the two videos.</p> <p> </p> <p>The combination of medication led to significant analgesia, without a between-group difference. Positive information about side effects increased the attribution of AE to the treatment compared to the control information. The total GASE score was correlated with analgesia, i.e., the more AEs reported, the stronger the analgesia. Interestingly, there was a significant between-groups difference on this correlation: the GASE score and analgesia correlated only in the positive information group. This provides evidence for a selective link between AEs and pain relief in the group who received the suggestion that AEs could be taken as a sign “that help was on the way”. During debriefing, 65% of participants said they would prefer to receive the positive message in a clinical context. These results suggest feasibility and validity to investigate such a framing of side effects in a clinical context, for example in patients with chronic pain.</p>
3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects
<p>The dataset contains the underlying data for the figures in the paper "3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects" by M. Forni et al., Science Advances, 2021. In the reported study, we present a newly developed biocompatible gelatin-embedded cluster of microelectrodes that enable higly customizable stimulation in the periaqueductal gray/dorsal raphe nucleus in awake rats. We were able to select a subset of electrodes for each individual, that upon stimulation provided significant pain inhibition during both normal and hyperalgesia conditions, without noticable side effects.</p> <p>Pain responses were quantified in terms of evoked field potentials (FP) and neuronal activity (z score), as well as withdrawal rate (WR) resulting from stimulating the skin with either a CO2-laser or a tactile stimulator, and analyzed with respect to multiple variables, such as time from stimulation onset, effect in comparison to morphine administration etc. Also, the effects of stimulation were quantified in terms of gait parameters (speed and paw-usage symmetry).</p> <p>The location of implanted electrodes was verified using computed tomography (CT) imaging and superimposition to the Waxholm brain atlas. The dataset contains the CT images for each anaimal, as obtained after alignment to the atlas.</p>
Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)
ClinicalTrials.gov study NCT03237481. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Patient Controlled Analgesia Pharmacogenetic Study
ClinicalTrials.gov study NCT01731873. IPD Sharing: YES. Countries: 1. Publications: 86.
Two Dose Epidural Morphine for Post-cesarean Analgesia
ClinicalTrials.gov study NCT01844206. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vibration Analgesia in Propofol Infusion During Anesthesia Induction
ClinicalTrials.gov study NCT03509857. IPD Sharing: NO. Countries: 1. Publications: 9.
Comparison of PIEB vs CEI for Labor Analgesia
ClinicalTrials.gov study NCT02949271. IPD Sharing: UNDECIDED. Countries: 1. Publications: 10.
Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery
ClinicalTrials.gov study NCT02356198. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lidocaine Analgesia For Removal Of Wound Vac Dressings
ClinicalTrials.gov study NCT01126359. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department
ClinicalTrials.gov study NCT02916927. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty
ClinicalTrials.gov study NCT07350252. IPD Sharing: NO. Countries: 1. Publications: 10.
A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery
ClinicalTrials.gov study NCT04015908. IPD Sharing: NO. Countries: 1. Publications: 1.
Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular Tachycardia
ClinicalTrials.gov study NCT01901575. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.