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10 results for “Antagonistic pleiotropy”
Data from: Precise colocalization of sorghum’s major chilling tolerance locus with Tannin1 due to tight linkage drag rather than antagonistic pleiotropy
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Data from: A benign juvenile environment reduces the strength of antagonistic pleiotropy and genetic variation in the rate of senescence
1. The environment can play an important role in the evolution of senescence because the optimal allocation between somatic maintenance and reproduction depends on external factors influencing life expectancy. 2. The aims of this study were to experimentally test whether environmental conditions during early life can shape senescence schedules, and if so, to examine whether variation among individuals or genotypes with respect to the degree of ageing differs across environments. 3. We tested life-history plasticity and quantified genetic effects on the pattern of senescence across different environments within a reaction norm framework by using an experiment on the three-spined stickleback (Gasterosteus aculeatus, Linnaeus) in which F1 families originating from a wild annual population experienced different temperature regimes. 4. Male sticklebacks that had experienced a more benign environment earlier in life subsequently reduced their investment in carotenoid-based sexual signals early in the breeding season, and consequently senesced at a slower rate later in the season, compared to those that had developed under harsher conditions. This plasticity of ageing was genetically determined. Both antagonistic pleiotropy and genetic variation in the rate of senescence were evident only in the individuals raised in the harsher environment. 5. The experimental demonstration of genotype-by-environment interactions influencing the rate of reproductive senescence provides interesting insights into the role of the environment in the evolution of life-histories. The results suggest that benign conditions weaken the scope for senescence to evolve, and that the dependence on the environment may maintain genetic variation under selection.
Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?
The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l−1) than women with genotypes without ApoE4 (120.49 pmol l−1), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.
Data from: Antagonistic selection and pleiotropy constrain the evolution of plant chemical defenses
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Data from: A benign juvenile environment reduces the strength of antagonistic pleiotropy and genetic variation in the rate of senescence
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Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?
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Data from: Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response
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Data from: Antagonistic pleiotropy in species with separate sexes, and the maintenance of genetic variation in life-history traits and fitness
Antagonistic pleiotropy (AP) – where alleles of a gene increase some components of fitness at a cost to others – can generate balancing selection, and contribute to the maintenance of genetic variation in fitness traits, such as survival, fecundity, fertility, and mate competition. Previous theory suggests that AP is unlikely to maintain variation unless antagonistic selection is strong, or AP alleles exhibit pronounced differences in genetic dominance between the affected traits. We show that conditions for balancing selection under AP expand under the likely scenario that the strength of selection on each fitness component differs between the sexes. Our model also predicts that the vast majority of balanced polymorphisms have sexually antagonistic effects on total fitness, despite the absence of sexual antagonism for individual fitness components. We conclude that AP polymorphisms are less difficult to maintain than predicted by prior theory, even under our conservative assumption that selection on components of fitness is universally sexually concordant. We discuss implications for the maintenance of genetic variation, and for inferences of sexual antagonism that are based on sex-specific phenotypic selection estimates – many of which are based on single fitness components.
Data from: The basis of antagonistic pleiotropy in hfq mutations that have opposite effects on fitness at slow and fast growth rates
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Data from: Antagonistic pleiotropy in species with separate sexes, and the maintenance of genetic variation in life-history traits and fitness
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.