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269 results for “Antibody responses”
Pre-vaccination and early B cell signatures of the antibody response to SARS-CoV-2 mRNA vaccine
<p>The data presented in Code repository for Kardava, L., Rachmaninoff, N., Lau, W. W., Buckner, C. M., Trihemasava, K., Blazkova, J., ... & Moir, S. (2022). Early human B cell signatures of the primary antibody response to mRNA vaccination. Proceedings of the National Academy of Sciences, 119(28), e2204607119.<a href="https://www.pnas.org/doi/epdf/10.1073/pnas.2204607119">https://www.pnas.org/doi/epdf/10.1073/pnas.2204607119</a> are made available here.</p> <p>All code to reproduce the figures can be found here: https://github.com/niaid/COVID_Vaccine_Bcells</p> <p><a href="https://zenodo.org/api/files/f93859d0-b062-4def-8b17-c0f21ee36f09/all_subjects_cd19_positive_and_keys.zip">all_subjects_cd19_positive_and_keys.zip</a> contains a CSV file of all CD19+ cells with flowSOM clusters shown. Accompanying files allow for matching of timepoint and subject information.</p> <p><a href="https://zenodo.org/api/files/f93859d0-b062-4def-8b17-c0f21ee36f09/All_subjects_FCS_files_deidentified.zip">All_subjects_FCS_files_deidentified.zip</a> contains the raw fcs files and is organized by timepoint and subject.</p>
Fig. 4 T cell and antibodies responses acter three immunisations with T in SjTat-TPI facilitates adaptive T-cell responses and reduces hepatic pathology during Schistosoma japonicum infection in BALB/c mice
Fig. 4 T cell and antibodies responses acter three immunisations with T-TPI + IFA, TPI + IFA, IFA and PBS. a and b: Percentages oc CD3+CD4+IFN-γ+ (Th1) and CD3+CD8+IFN-γ+ (Tc1) gated crom CD3+ cells analvsed bv FACS. c. IgG, IgG1 and IgG2a lesels in mice sera were detected. Data are presented as the means ± SEM crom eight mice in each group. (*P <0.05; **P <0.01)
Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses
<p>Bulk RNA-seq analysis of sorted subpopulations isolated from PBMC of yellow fever vaccinees from before and 3, 7, 14 and 28 days after vaccination and single cell RNA-seq analysis of sorted DC and monocytes fractions isolated from PBMC of of yellow fever vaccinees from before and 3 and 7 days after vaccination.</p>
Data from: A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies
<p><em>Streptococcus pneumoniae</em> (Spn) remains a major cause of global mortality, with extensive antigenic diversity between capsular serotypes that poses an ongoing challenge for vaccine development. Widespread use of pneumococcal conjugate vaccines (PCVs) targeting Spn capsules has greatly reduced infections by vaccine-included serotypes, but has led to increased infections by non-included serotypes. To date, high cost of PCVs has also limited their usefulness in low-income regions where disease burdens are highest. To overcome these limitations, serotype-independent vaccines are being actively researched. We have developed a whole-cell gamma-irradiated Spn vaccine (termed Gamma-PN) providing serotype-independent protection. We demonstrate that Gamma-PN immunization via the clinically relevant intramuscular route induces protein-specific antibodies able to bind numerous non-vaccine encapsulated serotypes, which mediate opsonophagocytic killing and protection against lethal challenges. Gamma-PN induced comparable or superior OPKA responses to serotypes found in the licensed Prevnar13 (PCV13), and a superior response to non-included serotypes, including emergent 22F and 35B. Additionally, despite a lower observed reactogenicity, administration of Gamma-PN without adjuvant resulted in higher OPKA responses and improved protection compared to adjuvanted Gamma-PN. To our knowledge, this has never been demonstrated for a whole-inactivated Spn vaccine. Eliminating the requirement for adjuvant comes with numerous benefits for clinical applications of this vaccine, and poses interesting questions for the inclusion of adjuvant in similar vaccines in development.</p>
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.
<p>Here you will find the raw data (RawData.RData) and code (CHIVAS_SEROLOGY_Code.Rmd, an R Markdown file) for generating the analysis and figures for the following publication:</p> <p><strong><em>Streptococcus pyogenes</em> pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.</strong></p> <p>Joshua Osowicki1,2,3 #, Hannah R Frost1 #, Kristy I Azzopardi1, Alana L Whitcombe4, Reuben McGregor4, Lauren H. Carlton4, Ciara Baker1, Loraine Fabri1,5,6, Manisha Pandey7, Michael F Good7, Jonathan R. Carapetis8,9,10, Mark J Walker11,12,13, Pierre R Smeesters1,2,5,6, Paul V Licciardi2,14, Nicole J Moreland4 *, Danika L Hill15 *, Andrew C Steer1,2,3 *</p> <p>Provided in the RData file are the following items: </p> <p><strong>Dataframes: </strong></p> <p>"outcome" : clinical variables associated with human challenge for each participant</p> <p>"data" : ELISA and functional antibody responses for human challenge participants. Each timepoint and isotype for each antigen as seperate column)</p> <p>"data_long": Data equivalent to "data" file but in long format, i.e. One column for each antigen, timepoint and isotype as factors. </p> <p>"data.melt" : Data equivalent to "data" file but in longer format , i.e. timepoint, isotype and antigen as factors, 'value' as ELISA AU. </p> <p>"luminex" : IgG responses to 6 antigens analysed by luminex bead-based assay in human challenge participants.</p> <p>"luminex.children" : IgG responses to 6 antigen analysed by luminex bead-based assay in children</p> <p><strong>Vectors:</strong></p> <p>"pharyngitis" : participant "id" for the 19 individuals that developed pharyngitis. </p> <p>"Antigen.Order" : relates to "Main" antigen classification used in Figure 2</p> <p>'additional" : relates to "Additional </p> <p><strong>Function: </strong></p> <p>"custom_theme" : used as a theme when using ggplot to graph. </p> <p>Adobe Illustrator or Inkscape were used to generate the final image files for publication, with some graph editing to axes labels, font size, adding p-values etc. </p> <p> </p> <p><em><strong>Additional files: </strong></em></p> <p> 3 .csv files have been included for download</p> <p>"ELISA_data_wide_format.csv", a wide format data table of 25 human challenge individuals and 219 variables. Equivalent to the 'data' dataframe in the RData file</p> <p>"CHIVAS_luminex.csv", a long format data table of 25 human challenge participants at 1 week, 1 month, and 3 months. Equivalent to the 'luminex' dataframe in the RData file. </p> <p>"Luminex.children.csv", a datatable of 6 luminex variables for 39 children (healthy and post pharyngitis). Equivalent to the 'luminex.children' dataframe in the RData file. </p> <p> </p>
Dataset and R code: Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
<p>The R code and dataset for the figures created in the Nature communications manuscript titled "<strong>Prior exposure to <em>B. pertussis </em>shapes the mucosal antibody response to acellular pertussis booster vaccination"</strong>.</p> <p>contains:</p> <p>- excel dataset including the parameters needed for the figures</p> <p>- R code document with the code used to produce the figures and statistical analyses</p>
Modeling the Sequence Dependence of Differential Antibody Binding in the Immune Response to Infectious Disease
<p>Raw peptide microarray data of fluorescence intensities representing relative binding of antibodies in sera samples collected from different cohorts of patients diagnosed with a number of viral infections. Healthy controls are also included.</p> <p>Columns:</p> <p>Sequence - peptide sequence</p> <p>HCV - Hepatitis Virus C</p> <p>Dengue - Dengue virus</p> <p>WNV - West Nile Virus</p> <p>HBV - Hepatitis Virus B</p> <p>Chagas - Chagas disease</p> <p>ND - negative/healthy donor</p> <p>LowCV - low coefficient of variation</p> <p>HighCV - high coefficient of variation</p>
Data from: Genome-wide epitope mapping reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection
<p><em>Coxiella burnetii</em> is an important zoonotic bacterial pathogen of global importance, causing the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep and goats, are considered the main reservoir of infection. Vaccination is a key control measure and two commercial vaccines based on formalin-inactivated<em> C. burnetii </em>bacterins are currently available. However, their deployment is limited due to significant reactogenicity in individuals previously sensitized to <em>C. burnetii </em>antigens. Furthermore, these vaccines interfere with available serodiagnostic tests which are also based on <em>C. burnetii</em> bacterin preparations. Subunit vaccines based on recombinant proteins offer significant advantages, as they can be designed to reduce reactogenicity and can be co-designed with defined antigen serodiagnostic tests to allow discrimination between vaccinated and infected individuals. This study aimed to investigate the diversity of antibody responses to <em>C. burnetii </em>vaccination and/or infection in cattle, goats, humans, and sheep through genome-wide linear epitope mapping to identify candidate vaccine and diagnostic antigens within the predicted bacterial proteome. Using high-density peptide microarrays, we analyzed the seroreactivity in 156 serum samples from vaccinated and infected individuals to peptides derived from 2,092 ORFs in the <em>C. burnetii</em> genome. We found significant diversity in the antibody responses within and between species and across different <em>C. burnetii</em> exposure statuses. However, <em>C. burnetii</em> exposure did result in more uniform seroreactivity across species. Through the implementation of three different vaccine candidate methods, we identified 493 candidate protein antigens for protein subunit vaccine design or serodiagnostic, out of which 65 have been previously described. This is the first study to investigate seroreactivity against the entire <em>C. burnetii </em>genome presented as overlapping linear peptides and provides the basis for selection of antigen targets for next generation Q fever vaccines and diagnostic tests.</p>
A Study to Assess the Antibody Response of Healthy Chinese Children Who Have Been Vaccinated Previously With 4-doses of Prevenar (a Pneumococcal Vaccine) as Babies and Toddlers
ClinicalTrials.gov study NCT01298544. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessing the Use of Certolizumab Pegol in Adult Subjects With Rheumatoid Arthritis on the Antibody Response When Receiving Influenza Virus and Pneumococcal Vaccines
ClinicalTrials.gov study NCT00993668. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate 4-year Antibody Persistence and Booster Response Following MenABCWY Vaccination in Healthy Adolescents and Young Adults Who Previously Participated in Studies V102_02 (NCT01210885)
ClinicalTrials.gov study NCT02451514. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Plasmablast Trafficking and Antibody Response in Influenza Vaccination (SLVP021 2011-2014)
ClinicalTrials.gov study NCT02141581. IPD Sharing: YES. Countries: 1. Publications: 3.
Magnitude of the Antibody Response to and Safety of a GBS Trivalent Vaccine in HIV Positive and HIV Negative Pregnant Women and Their Offsprings
ClinicalTrials.gov study NCT01412801. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children
ClinicalTrials.gov study NCT00771849. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Persistence Of Antibody Responses Among Children Who Previously Received Novartis MenACWY Conjugate Vaccine or Meningococcal C Conjugate Vaccine
ClinicalTrials.gov study NCT01345721. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Persistence of Antibody Levels and Response to Fifth or Third Meningococcal B Recombinant Vaccine in 4-year Old Healthy Children Who Previously Participated in Study V72P12E1
ClinicalTrials.gov study NCT01717638. IPD Sharing: Not stated. Countries: 4. Publications: 1.
The Aim of This Study is to Investigate the Persistence of Antibody Response in Adults up to 15 Years After One Booster Dose of GlaxoSmithKline (GSK) Biologicals' Encepur Adults Vaccine
ClinicalTrials.gov study NCT03294135. IPD Sharing: NO. Countries: 1. Publications: 1.
An Observational Study Evaluating Anti-Idursulfase Serum Antibody Response in Hunter Syndrome Patients
ClinicalTrials.gov study NCT00882921. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Study to Evaluate the Long-term Antibody Persistence of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine (GSK134612) Versus Mencevax ACWY in Healthy Adolescents and Adults and Booster Response to
ClinicalTrials.gov study NCT01934140. IPD Sharing: YES. Countries: 1. Publications: 1.
Study Evaluating Persistence Of Antibody Response Elicited By 13vPnC In Healthy Adults Previously Vaccinated
ClinicalTrials.gov study NCT01025336. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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