Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
237
datasets available to search
ShareScore release 0.9.0
Dataset results
237 results for “Antifungals”
Antifungal activity of propolis extract against Candida albicans in patients with vulvovaginal candidiasis
<p>Abstract</p> <p><strong>Objective:</strong> To evaluate the antifungal activity of propolis extract against <em>Candida Albicans</em> (or <em>C. Albicans</em>) in patients with vulvovaginal candidiasis.</p> <p><strong>Method:</strong> The research presents a quantitative approach with an experimental design, with a population of <em>C. Albicans</em> strains isolated from patients diagnosed with vulvovaginal candidiasis who were admitted to the Gynecology Service of the Maria del Socorro Clinic, district of Ate - Lima, from which a sample of 34 strains was chosen in total, considering three repetitions per strain, obtaining 102 experimental units.</p> <p>The antifungal susceptibility test was carried out by the disc diffusion plate method using a single concentration of propolis extract, with fluconazole as a positive control.</p> <p><strong>Resultados:</strong> Propolis extract was shown to inhibit all strains of <em>C. albicans</em>, as was fluconazole, with the effect of the latter being significantly greater than that of the product under investigation.</p> <p><strong>Conclusion:</strong> The conclusion is that propolis extract does show antifungal activity against <em>C. albicans</em> in patients with vulvovaginal candidiasis.</p> <p><strong>Keywords:</strong> Propolis extract, <em>Candida Albicans</em>, Antifungal activity, Vulvovaginal candidiasis.</p> <p> </p>
Figure 5 in In vitro antifungal and antibacterial potentials of organic extracts of Avicennia marina collected from Rabigh Lagoon, Red Sea Coasts in Saudi Arabia
Figure 5. Comparison of MIC with MBC values (mg/mL) of A. marina in different solvents: a: Petroleum ether; b: Ethyl acetate. All tests were performed in triplicates (n = 3) and the error bars represent the SD. * p <0.05, ** p <0.01, *** p <0.001 with respect to the control. NS: not significant.
Figure 3 in In vitro antifungal and antibacterial potentials of organic extracts of Avicennia marina collected from Rabigh Lagoon, Red Sea Coasts in Saudi Arabia
Figure 3. Comparison of MIC values (mg/mL) of A. marina different extracts. All tests were performed in triplicates (n = 3) and the error bars represent the SD. * p <0.05, ** p <0.01, *** p <0.001 with respect to the control.
Figure 2 in In vitro antifungal and antibacterial potentials of organic extracts of Avicennia marina collected from Rabigh Lagoon, Red Sea Coasts in Saudi Arabia
Figure 2. Antagonistic effect expressed by the inhibition zone of Ethyl acetate extract on the growth of: (A):A. fumigatus; (B):C. albicanis.
Figure 1 in In vitro antifungal and antibacterial potentials of organic extracts of Avicennia marina collected from Rabigh Lagoon, Red Sea Coasts in Saudi Arabia
Figure 1. The antifungal effect of plant extracts from Avicennia marina against some pathogenic fungi expressed by zones of inhibition (ZI in mm). All tests were performed in triplicates (n = 3) and the error bars represent the SD. * p <0.05, ** p <0.01, *** p <0.001 with respect to the control. NS: not significant.
Raw and analyzed data for manuscript "In vitro eradication of Candida albicans biofilm through cold atmospheric plasma: Unravelling the interdependence of exposure and voltage in the antifungal mode of action."
<p><strong><span>Raw and analysed data for the manuscript, to be submitted to Journal of Infection and Public Health.</span></strong></p> <p> </p> <p><strong><span>Abstract:</span></strong></p> <p><strong><span>Introduction:</span></strong><span> Since <em>Candida spp</em>.</span> <span>is the fourth leading cause of healthcare-associated infections globally, the need for novel antifungal agents is increasing among scientists. This study investigates the potential of cold atmospheric plasma for <em>C. albicans</em> biofilm treatment. <strong>Methods:</strong> Our research focused on <em>in vitro</em> <em>C. albicans</em> biofilm response to varying parameters of plasma application, specifically the impact of treatment duration and input voltage. Evaluation of plasma influence on <em>C. albicans</em> was assessed with viability, membrane integrity, and oxidative stress measurements, along with observations of biofilm chemical composition and hyphae growth after plasma treatment. <strong>Results and Discussion:</strong> The higher plasma input voltage and increased exposure tme resulted in lower <em>C. albicans</em> cell viability, with complete reductions observed after 5 min plasma treatment duration across all input voltages tested. The effect of plasma treatment was further confirmed with a microscopic examination after BacLight<sup>® </sup>staining.</span> <span>Low (8 V) CAP exposure could potentially lead to a phenomenon known as hormesis, which was observed in <em>C. albicans</em> 24 h growth measurements. Additionally, intracellular oxidative stress assessment further proved that with prolonged treatment times, the intensity of oxidative stress, increased. Plasma treatment also affected the hyphae, which exhibited signs of contraction and compression. The chemical characteristics revealed that increasing plasma voltage and exposure time also have a distinguished impact on lipids, proteins, and carbohydrates, typical constituents of fungi biofilms. <strong>Conclusion:</strong> This study underscores the potential of plasma as a promising approach in combating <em>Candida spp</em>. biofilms, shedding light on the intricate dynamics of its impact on biofilm viability, morphology and composition.</span></p>
Data of Fig 4 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 4 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Figure 5 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 5 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Dataset of Fig 3 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 3 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Associated coordinate and mtz files for "Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio- selective oxidation of antifungal macrolides"
<p>Coordinate and mtz files for the associated protein structures reported in "Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio- selective oxidation of antifungal macrolides".</p>
Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens
<p>In the healthcare sector, the production of bioactive silver nanoparticles (AgNPs) with antimicrobial properties is of great importance. In this study, a novel bacterial strain, <em>Paenibacillus</em> sp. MAHUQ-63, was identified as a potential candidate for facile and rapid biosynthesis of AgNPs. The synthesized AgNPs were used to control the growth of human pathogens, <em>Salmonella</em> Enteritidis and <em>Candida</em> <em>albicans</em>. The bacterial culture supernatant was utilized to synthesize the nanoparticles. FE-TEM examination showed spherical-shaped nanoparticles with 15 to 55 nm in size. FTIR analysis identified various functional groups. The synthesized AgNPs demonstrated remarkable activity against <em>S</em>. Enteritidis and <em>C. albicans</em>. The zone of inhibition (ZOI) for 100 µL (0.5 mg/mL) of AgNPs against <em>S</em>. Enteritidis and <em>Candida</em> <em>albicans</em> were 18.0 ± 1.0 and 19.5 ± 1.3 mm, respectively. The minimum inhibitory concentrations (MICs) were 25.0 and 12.5 μg/mL against <em>S</em>. Enteritidis and <em>Candida albicans</em>, respectively. Additionally, the minimum bactericidal concentrations (MBC) were 25.0 μg/mL against both pathogenic microbes. The FE-SEM analysis showed that the treatment of AgNPs caused morphological and structural damage to both <em>S</em>. Enteritidis and <em>Candida albicans</em>. Therefore, these AgNPs can be used as a new and effective antimicrobial agent.</p>
Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis
ClinicalTrials.gov study NCT00862654. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Caspofungin or Micafungin as Empiric Antifungal Therapy for Persistent Fever and Neutropenia
ClinicalTrials.gov study NCT00723073. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Efficacy of Antifungal Treatment
ClinicalTrials.gov study NCT00934934. IPD Sharing: Not stated. Countries: 1. Publications: 28.
Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment
ClinicalTrials.gov study NCT03059992. IPD Sharing: NO. Countries: 8. Publications: 1.
Antifungal Locks to Treat Fungal-related Central Line Infections
ClinicalTrials.gov study NCT00936910. IPD Sharing: YES. Countries: 1. Publications: 14.
Cold atmospheric plasma improves antifungal responsiveness of Aspergillus flavus and Fusarium keratoplasticum conidia and mycelia
Open the record for dataset details and reuse information.
Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens
Open the record for dataset details and reuse information.
Data from: Young but not defenseless: antifungal activity during embryonic development of a social insect
Termites live in environments heavily colonized by diverse microbial communities, including pathogens. Eggs laid within the nest likely experience similar pathogenic pressures as their older nestmates. Consequently, they may have also been under selective pressures to be immune-competent. Through in vitro experiments, we tested the ontogeny, location and strength of embryos' antifungal activity against the fungus Metarhizium brunneum. Extraembryonic washes and intraembryonic components were incubated with fungal conidia, which was then scored for viability. Fungistatic activity was location- and stage-dependent. Extraembryonic washes had relatively weak antifungal activity. Conversely, intraembryonic contents were highly antifungal, exhibiting increased potency through development. Boiling both embryonic washes and intraembryonic contents rescued conidia viability, indicating the antifungal agent(s) is (are) likely proteinaceous. Embryonic protein profiles shifted from putative vitellogenins in young embryos to multiple proteins in subsequent stages, suggesting that the increase in fungistatic activity may be due to the expression of endogenous proteins during embryogenesis. This study is the first to address embryonic antifungal activity in a hemimetabolous eusocial taxon. Our results support the hypothesis that microbes have been significant agents of selection, fostering the evolution of antifungal properties even in the most immature and supposed, most vulnerable stage of development.
Fig. 5 in Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves
Fig. 5. The effects of temperature (a) and pH (b) on the stability of Skh-AMP1 as measured by its biological activity toward Aspergillus fumigatus growth. (c) Assay of Skh-AMP1cytotoxicity against HEK293 cells after 6, 24 and 48 h time periods. Results represent mean ± SD of three independent experiments.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.