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62 results for “Antimicrobial Use”
Data set for publication: Determination of Virulence-Associated Genes and Antimicrobial Resistance Profiles in Brucella Isolates Recovered from Humans and Animals in Iran Using NGS Technology
<p>This dataset includes information on resistance profiling, as well as antimicrobial resistance (AMR) genes and virulence-related factors that were identified in <em>Brucella</em> isolates recovered from humans and animals in different regions of Iran using classical phenotyping and next-generation sequencing (NGS) technology.</p>
Land use influences the composition and antimicrobial effects of propolis
<p>Honey bee propolis is a complex, resinous mixture created by bees using plant sources such as leaves, flowers, and bud exudates. This study characterized how cropland surrounding apiaries affects the chemical composition and antimicrobial effects of propolis. The chemical composition and compound abundance of the propolis samples were analyzed using Gas Chromatography-Mass Spectrometry (GC-MS) and the antimicrobial effects were analyzed using the 50% minimum inhibitory concentration (MIC<sub>50</sub>) assay against four relevant bee pathogens, <span class="html-italic">Serratia marcescens, Paenibacillus larvae, Lysinibacillus sphaericus,</span> and <span class="html-italic">Klebsiella pneumoniae</span>. Propolis composition varied significantly with apiary, and cropland coverage predicted mean sum abundance of compounds. The apiary with the highest cropland coverage exhibited significantly higher MIC<sub>50</sub> values for <span class="html-italic">S. marcescens</span> and <span class="html-italic">K. pneumoniae</span> compared to other apiaries. These results demonstrate that agricultural land use surrounding honey bee apiaries decreases the chemical quality and antimicrobial effects of propolis, which may have implications for the impacts of land use on hive immunity to potential pathogens.</p>
Green synthesis of ZnO nanoparticles using Cocos nucifera leaf extract: Characterization, antimicrobial, antioxidant, and photocatalytic activity
<p>Zinc oxide nanoparticles (ZnO NPs) have been successfully prepared using <em>Cocos nucifera</em> leaf extract and investigated with their antimicrobial, antioxidant, and photocatalytic activity. The structural, compositional, and morphological properties of the NPs were recorded and studied systematically to confirm the synthesis. The aqueous suspension of NPs showed a UV-Vis. absorption maxima of 370 nm indicating primarily its formation. The XRD analysis identified the NPs with hexagonal wurtzite structure with an average particle size of 16.6 nm. The FTIR analysis identified some biomolecules and functional groups in the leaf extract as responsible for the encapsulation and stabilization of ZnO NPs. The EDX analysis showed the desired elemental compositions in the material. A flower-shaped morphology of ZnO NPs was observed by SEM with a grain size of around 15 nm. The optical properties of the NPs were studied by UV-Vis spectroscopy and the bandgap was calculated as 3.37 eV. The Prepared ZnO NPs have demonstrated antimicrobial activity against <em>T. harzianum</em>, and <em>S. aureus</em> with a ZOI (zone of inhibition) of 14 and 10 mm, respectively. The photocatalytic behavior of ZnO NPs showed absorbance degradation at around 640 nm and discolored methylene blue dye after one hour with a degradation maximum of 84.29 %. Thus, the prepared ZnO NPs could be used potentially in antibiotic development, pharmaceutical industries, and as photocatalysts. </p>
Dataset for: Social dilemma in the excess use of antimicrobials incurring antimicrobial resistance
<p><span>This is the dataset for the study of "Social dilemma in the excess use of antimicrobials incurring antimicrobial resistance". </span></p> <p><span>The emergence of antimicrobial resistance (AMR) caused by the excess use of antimicrobials has come to be recognized as a global threat to public health. There is a 'tragedy of the commons' type social dilemma behind this excessive use of antimicrobials, which should be recognized by all stakeholders. To address this global threat, we thus surveyed eight countries/areas to determine whether people recognize this dilemma and showed that although more than half of the population pays little, if any, attention to it, almost 20% recognize this social dilemma, and 15–30% of those have a positive attitude toward solving that dilemma. We suspect that increasing individual awareness of this social dilemma contributes to decreasing the frequency of AMR emergencies.</span></p>
Assessment of antimicrobial activity of melittin encapsulated in bicontinuous microemulsions prepared using renewable oils
<p>The objective of this study is to demonstrate that melittin, a well-studied antimicrobial peptide (AMP), can be solubilized in an active form in bicontinuous microemulsions (BMEs) that employ biocompatible oils. The systems investigated consisted of Winsor-III and -IV BME phases composed of Water/Aerosol-OT (AOT)/Polysorbate 85/isopropyl myristate and a Winsor-IV BME employing Polysorbate 80 and limonene. We found that melittin resided in an a-helix-rich configuration and was in an apolar environment for the AOT/Polysorbate 85 Winsor-III system, suggesting that melittin interacted with the surfactant monolayer and was in an active conformation. An apolar environment was also detected for melittin in the two Winsor-IV systems, but to a lesser extent than the Winsor-III system. Small-angle X-ray scattering analysis indicated that melittin at a concentration of 1.0 g/L<sub>aq</sub> in the aqueous subphase of the Winsor-IV systems led to the greatest impact on the BME structure (e.g., decrease of quasi-periodic repeat distance and correlation length and induction of interfacial fluidity). The antimicrobial activity of the Polysorbate 80 Winsor-IV system was evaluated against several bacteria prominent in chronic wounds and surgical site infections (SSIs). Melittin-free BMEs inhibited the growth of all tested bacteria due to its oil, limonene, while the inclusion of 1.0 g/L<sub>aq</sub> of melittin in the BMEs enhanced the activity against several bacteria. A further increase of melittin concentration in the BMEs had no effect. These results demonstrate the potential utility of BMEs as a delivery platform for AMPs and other hydrophilic and lipophilic drugs to inhibit antibiotic-resistant microorganisms in chronic wounds and SSIs.</p>
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias
ClinicalTrials.gov study NCT03244917. IPD Sharing: NO. Countries: 1. Publications: 3.
The Use of Probiotics to Evaluate Colonization With Antimicrobial Resistant Bacteria
ClinicalTrials.gov study NCT01551186. IPD Sharing: Not stated. Countries: 1. Publications: 5.
De-Implementation of Inappropriate Antimicrobial Use After Cardiac Device Procedures
ClinicalTrials.gov study NCT05020418. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessment of antimicrobial activity of melittin encapsulated in bicontinuous microemulsions prepared using renewable oils
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Dataset for: Social dilemma in the excess use of antimicrobials incurring antimicrobial resistance
Open the record for dataset details and reuse information.
Land use influences the composition and antimicrobial effects of propolis
Open the record for dataset details and reuse information.
Green synthesis of ZnO nanoparticles using Cocos nucifera leaf extract: Characterization, antimicrobial, antioxidant, and photocatalytic activity
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Data from: A controlled quasi-experimental study of an educational intervention to reduce the unnecessary use of antimicrobials for asymptomatic bacteriuria
Background: Asymptomatic bacteriuria (ABU) should only be treated in cases of pregnancy or in-patients undergoing urologic procedures; however, unnecessary treatment of ABU is common in clinical practice. Objective: To identify risk factors for unnecessary treatment and to assess the impact of an educational intervention focused on these risk factors on treatment of ABU. Design: Quasi-experimental study with a control group. Setting: Two tertiary teaching adult care hospitals. Participants: Consecutive patients with positive urine cultures between January 30th and April 17th, 2012 (baseline) and January 30th and April 30th, 2013 (intervention). Intervention: In January 2013, a multifaceted educational intervention based on risk factors identified during the baseline period was provided to medical residents (monthly) on one clinical teaching unit (CTU) at one hospital site, with the CTU of the other hospital serving as the control. Results: During the baseline period, 160/341 (46.9%) positive urine cultures were obtained from asymptomatic patients at the two hospitals, and 94/160 (58.8%) were inappropriately treated with antibiotics. Risk factors for inappropriate use included: female gender (OR 2.1, 95% CI 1.1-4.3), absence of a catheter (OR 2.5, 1.2-5), bacteriuria versus candiduria (OR 10.6, 3.8-29.4), pyuria (OR 2.0, 1.1-3.8), and positive nitrites (OR 2.2, 1.1-4.5). In 2013, only 2/24 (8%) of ABU patients were inappropriately treated on the intervention CTU as compared to 14/29 (52%) on the control CTU (OR 0.10; 95% CI 0.02-0.49). A reduction was also observed as compared to baseline on the intervention CTU (OR 0.1, 0.02-0.7) with no significant change noted on the control CTU (OR 0.47, 0.13-1.7). Conclusions: A multifaceted educational intervention geared towards medical residents with a focus on identified risk factors for inappropriate management of ABU was effective in reducing unnecessary antibiotic use.
Fig. 2 in Antimicrobial and antioxidant efficacy of Citrus limon L. peel extracts used for skin diseases by Xhosa tribe of Amathole District, Eastern Cape, South Africa
Fig. 2. Nitric oxide scavenging activity of Citrus limon extracts. Results are means of 3 replicates.
Assessing the antimicrobial Capacity of metal oxide nanomaterials using ZOI and MIC measurements by employing Machine learning tools.
<p>Assessing the antimicrobial Capacity of metal and metal oxide nanomaterials (IONPs, AgNPs, ZnONPs) using ZOI and MIC measurements by employing Machine learning tools.</p>
Database for publication Costs and benefits of innovations able to reduce the use of Antimicrobials on Pig and Broiler Farms
<p>Database for publication Costs and Benefits of Innovations able to Reduce the Use of Antimicrobials on Pig and Broiler Farms HSOA Journal of Animal Research and Veterinary Science 2023 7:052</p>
Use of Ozone Gel as an Antimicrobial in Treatment of Periodontitis
ClinicalTrials.gov study NCT05905445. IPD Sharing: NO. Countries: 1. Publications: 1.
Use of a Biofilm Antimicrobial Susceptibility Assay to Guide Antibiotic Therapy
ClinicalTrials.gov study NCT00786513. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antimicrobial Drug Use and Resistant Staphylococcus Aureus
ClinicalTrials.gov study NCT01075451. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Using Antibiotics Wisely - An Antimicrobial Stewardship Program
ClinicalTrials.gov study NCT04388293. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.