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26 results for “Antimicrobial agents”
Direct synthesis, characterization, in vitro and in silico studies of simple chalcones as potential antimicrobial and antileishmanial agents
<p>Chalcone represents a vital biosynthetic scaffold owing to its numerous therapeutic effects. The present study was intended to synthesize seventeen chalcone derivatives <strong>(3a-q)</strong> by direct coupling of substituted acetophenones and benzaldehyde. The target chalcones were characterized by spectroscopic analyses followed by their <em>in vitro</em> antimicrobial, and antileishmanial investigations with reference to standard drugs. The majority of the chalcones displayed good to excellent biological activities. Chalcone <strong>3q</strong> (1000 μg/mL) exhibited the most potent antibacterial effect with its zone of inhibition values of 30, 33, and 34 mm versus <em>Staphylococcus aureus,</em> <em>Escherichia coli, and Pseudomonas aeruginosa </em>respectively. The results also confirmed chalcone <strong>3q</strong> to be the most potent versus <em>Leishmania major </em>with the lowest IC<sub>50</sub> value of 0.59±0.12 μg/mL.<em> </em>Chalcone <strong>3i</strong> (500 μg/mL) was noticed to be the most potent antifungal agent with its zone of inhibition being 29 mm against <em>Candida albicans</em>. Computational studies of chalcones <strong>3i </strong>and<strong> 3q</strong> supported the preliminary <em>in vivo</em> results. The existence of the amino moiety and bromine atom on ring-A and methoxy moieties on ring-B caused better biological effects of the chalcones. In brief, the investigations reveal that chalcones (<strong>3i </strong>and<strong> 3q) </strong>can be employed as building blocks<strong> </strong>to discover novel antimicrobial agents.</p>
Direct synthesis, characterization, in vitro and in silico studies of simple chalcones as potential antimicrobial and antileishmanial agents
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Clinical Evaluation and Antimicrobial Effect of Papain Based Chemo-mechanical Caries Removal Agents
ClinicalTrials.gov study NCT05983900. IPD Sharing: YES. Countries: 1. Publications: 1.
Comparison of the Effectiveness of Hypochlorous Acid and Chlorhexidine as a Post-surgical Antimicrobial Agent
ClinicalTrials.gov study NCT05952921. IPD Sharing: NO. Countries: 1. Publications: 2.
Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter
ClinicalTrials.gov study NCT00286104. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Figure 8 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 8 Structures of compounds 7 (octanoyl derivative), 9 (myristoyl derivative), and 14 (dichloroacetyl derivative).
Scheme 1 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Scheme 1 Reagents and conditions: (a) dry Py, (C6H5)3COCl, –5 °C, 6 h, (70%; Rf = 0.52); (b) dry Py, various acyl halides (3–14), 0 °C to rt, DMAP, 6 h.
Figure 5 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 5 Percentage zone of mycelial growth inhibition for compounds 3 and 11 against A. niger (A and B, respectively). DMSO represents the negative control, whereas nystatin is the positive control.
Figure 2 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 2 Percentage of inhibition observed for A) B. subtilis by compounds 7, 9, and 8; B) E. coli by compounds 2, 4, and 9; C) S. abony by compounds 7, 9, and 14; and D) S. aureus by compounds 7, 9, and 14. DMSO was the negative control, whereas azithromycin represented the positive control.
Figure 7 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 7 Percentage growth inhibition observed for various concentrations of compound 9. Right figure 96-well flat-bottom experiment.
Data from: Wood ants produce a potent antimicrobial agent by applying formic acid on tree-collected resin
Wood ants fight pathogens by incorporating tree resin with antimicrobial properties into their nests. They also produce large quantities of formic acid in their venom gland, which they readily spray to defend or disinfect their nest. Mixing chemicals to produce powerful antibiotics is common practice in human medicine, yet evidence for the use of such "defensive cocktails" by animals remains scant. Here, we test the hypothesis that wood ants enhance the antifungal activity of tree resin by treating it with formic acid. In a series of experiments, we document that (i) tree resin had much higher inhibitory activity against the common entomopathogenic fungus Metarhizium brunneum after having been in contact with ants, while no such effect was detected for other nest materials; (ii) wood ants applied significant amounts of endogenous formic and succinic acid on resin and other nest materials; and (iii) the application of synthetic formic acid greatly increased the antifungal activity of resin, but had no such effect when applied to inert glass material. Together, these results demonstrate that wood ants obtain an effective protection against a detrimental microorganism by mixing endogenous and plant-acquired chemical defenses. In conclusion, the ability to synergistically combine antimicrobial substances of diverse origins is not restricted to humans and may play an important role in insect societies.
Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity
ClinicalTrials.gov study NCT02319668. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effectiveness of an Antimicrobial Agent for Preoperative Skin Preparation
ClinicalTrials.gov study NCT03224299. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Wood ants produce a potent antimicrobial agent by applying formic acid on tree-collected resin
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Phenotypically-anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish
GEO Series GSE80955. Danio rerio. 8 samples. Type: Expression profiling by array.
Figure 3 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 3 MIC values for compounds 7, 9, and 14.
Figure 6 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 6 MIC and MFC values for the compounds 7 and 14.
Figure 4 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 4 MBC data for compounds 7, 9, and 14.
Figure 1 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 1 Structure of the uridine (1).
The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries
ClinicalTrials.gov study NCT00612469. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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OpenNeuro
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