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77 results for “ApoE4”
Literature Review 13/02/2018: Genetic risk of Parkinson's disease dementia due to APOE4 or MAPT
<p>Literature review assessing genetic risk of dementia due to <em>APOE4</em> or <em>MAPT </em>in Parkinson's disease, performed on the 13<sup>th</sup> February 2018. All studies had to fulfil three<em> a priori </em>inclusion criteria:</p> <p>1) Case control studies using clinically diagnosed or pathologically confirmed PD and PDD.</p> <p>2) Time between motor diagnosis and experimental assessment could be defined or estimated.</p> <p>3) Genotype information supplied, allowing the odds ratio (OR) and confidence intervals (CI) to be calculated that aligned with the genotype categories used in this work.</p> <p>For <em>MAPT</em>, a PubMed search for the term “<em>MAPT Parkinson’s dementia</em>” identified 105 potential matches, of which 9 met the inclusion criteria. For <em>APOE4</em>, a PubMed search for the term “<em>APOE Parkinson’s dementia</em>” identified 188 potential matches, of which 19 met the inclusion criteria. Note, the review includes several publications arising from the CamPaIGN cohort; As we were interested in genetic risk as a function of time from diagnosis, we included each unique study time-point. </p>
Presence of the APOE4 allele is associated with an increased risk of sepsis progression
<p><strong>Supplementary Table 1. The Hardy-Weinberg equilibrium assay for APOE genotypes in healthy controls, sepsis, septic shock and all sepsis patients</strong>.</p>
APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
<p>In post-industrial settings, <i>APOE4</i> is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the <i>APOE4</i> allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N=1266), <i>APOE4</i> is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized-LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized-LDL and inflammation which were limited to high BMI adults. Further, <i>APOE4</i> carriers maintain higher levels of total and LDL cholesterol at low BMIs. These results suggest the relationship between <i>APOE4</i> and lipids may be beneficial for pathogen-driven immune responses, and unlikely to increase cardiovascular risk in an active subsistence population.</p>
APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
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Biomarker Effects of ALZ-801 in APOE4 Carriers With Early Alzheimer's Disease
ClinicalTrials.gov study NCT04693520. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers.
ClinicalTrials.gov study NCT03816228. IPD Sharing: NO. Countries: 1. Publications: 3.
Gene Therapy for APOE4 Homozygote of Alzheimer's Disease
ClinicalTrials.gov study NCT03634007. IPD Sharing: NO. Countries: 1. Publications: 1.
Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier)
ClinicalTrials.gov study NCT00575055. IPD Sharing: Not stated. Countries: 1. Publications: 6.
The Occurrence of the ApoE4 Allele in Agitated In-Patients With Late-Onset Alzheimer's Disease
ClinicalTrials.gov study NCT01329536. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier)
ClinicalTrials.gov study NCT00574132. IPD Sharing: Not stated. Countries: 4. Publications: 6.
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
ClinicalTrials.gov study NCT03978052. IPD Sharing: Not stated. Countries: 1. Publications: 22.
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
ClinicalTrials.gov study NCT07392723. IPD Sharing: YES. Countries: 1. Publications: 0.
Neuronal APOE4 removal strongly protects against Tau-mediated gliosis, neurodegeneration, and myelin deficits
GEO Series GSE221215. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic changes upon doxorubicin treatment in the brain of ApoE3 and ApoE4 rats
GEO Series GSE305230. Rattus norvegicus. 64 samples. Type: Expression profiling by high throughput sequencing.
APOE4 genotype confers transcriptomic and functional alterations to primary mouse microglia
GEO Series GSE171280. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing.
Synj 1 modulates functional recovery after motor-incomplete spinal cord injury in male mice carriers of human ApoE4.
GEO Series GSE227291. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
10x single-cell RNAseq profiling of CD45+ melanoma-infiltrating leukocytes from APOE2 and APOE4 knock-in mice
GEO Series GSE146613. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease
GEO Series GSE241553. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4
GEO Series GSE274869. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids
GEO Series GSE289912. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
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