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46 results for “Astaxanthin”
Metadata - Astaxanthin has a beneficial influence on pain-related symptoms and opioid-induced hyperalgesia in mice with diabetic neuropathy-evidence from behavioral studies
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Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
<p><strong><span>Scope:</span></strong><span> Evidence is mounting that astaxanthin (ATX), a xanthophyll carotenoid, used as a nutritional supplement to prevent chronic metabolic diseases. The present study aims to identify the potential function of ATX supplementation in preventing steatohepatitis and hepatic oxidative stress in diet-induced obese mice.</span></p> <p><strong><span>Methods and Results:</span></strong><span> In this study, ATX as dose of 0.25%, 0.5% and 0.75% have orally administered to mice along with a high-fat diet (HFD) to investigate the role of ATX in regulating liver lipid metabolism and gut microbiota. The study showed that ATX dose-dependently reduces body weight, lipid droplet formation, hepatic triglycerides and ameliorated hepatic steatosis and oxidative stress. 0.75% ATX altered the levels of 34 lipid metabolites related to hepatic cholesterol and fatty acid metabolism which might be associated with downregulation of lipogenesis-related genes and upregulation of bile acid biosynthesis-related genes. The result also revealed that ATX alleviates HFD-induced gut microbiota dysbiosis by significantly inhibiting the growth of obesity-related <em>Parabacteroides</em> and <em>Desulfovibrio</em> while promoting the growth of <em>Allobaculum</em> and <em>Akkermansia</em>. </span></p> <p><span><strong>Conclusion:</strong> The study results suggested that dietary ATX may prevent the development of hepatic steatosis and oxidative stress with the risk of metabolic disease by gut-liver axis modulating properties.</span></p>
Data from: Optimization and characterization of PLGA nanoparticles loaded with Astaxanthin and evaluation of anti-photodamage effect in vitro
<p><span><span>Astaxanthin is a xanthophyll carotenoid with </span><span>high</span><span> beneficial biological activities, such as antioxidant function and scavenging oxygen free radicals, but its application is limited because of poor water solubility and low bioavailability. Here, we prepared and optimized poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with astaxanthin using the emulsion solvent evaporation technique and investigated the anti-photodamage effect in Ha</span><span>C</span><span>a</span><span>T</span><span> cells. The four-factor three-stage Box-Behnken design was used to optimize the nanoparticle formulation. The experimental determination of the optimal nanoparticle size was 154.4 ± 0.35 nm, the zeta potential was 22.07 ± 0.93 mV, encapsulation efficiency was 96.42 ± 0.73%, and drug loading capacity was 7.19 ± 0.12%. The physicochemical properties of the optimized nanoparticles were characterized by dynamic light scattering, SEM, TEM, FTIR, XRD, DSC, and TGA. <i>In vitro</i> study exhibited the excellent cell viability and cellular uptake of optimized nanoparticle on Ha</span><span>C</span><span>a</span><span>T</span><span> cells. The anti-photodamage studies (cytotoxicity assay, ROS content, and JC-1 assessment) demonstrated that the optimized nanoparticles were more effective and safer than pure astaxanthin in Ha</span><span>C</span><span>a</span><span>T</span><span> cells. These results suggest that our PLGA-coated astaxanthin nanoparticles synthesis method was highly feasible, and can be used in cosmetics or the treatment of skin diseases.</span></span></p>
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
ClinicalTrials.gov study NCT05138549. IPD Sharing: NO. Countries: 1. Publications: 8.
Data from: Optimization and characterization of PLGA nanoparticles loaded with Astaxanthin and evaluation of anti-photodamage effect in vitro
Open the record for dataset details and reuse information.
Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
Open the record for dataset details and reuse information.
Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators
ClinicalTrials.gov study NCT03664466. IPD Sharing: NO. Countries: 1. Publications: 49.
Effects of Astaxanthin Supplementation
ClinicalTrials.gov study NCT06511960. IPD Sharing: NO. Countries: 1. Publications: 14.
Study of the Efficacy and Safety of Antioxidants Astaxanthin as an Adjuvant Therapy for Community Acquired Pneumonia Patients.
ClinicalTrials.gov study NCT06334874. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assisted Reproduction Techniques Procedures
ClinicalTrials.gov study NCT02310087. IPD Sharing: NO. Countries: 1. Publications: 9.
Effect of Astaxanthin Supplementation on Plasma Malondialdehyde Levels and NIHSS of Stroke Patients
ClinicalTrials.gov study NCT03945526. IPD Sharing: NO. Countries: 1. Publications: 6.
Evaluation of Astaxanthin Properties on Anti-fatigue
ClinicalTrials.gov study NCT06593535. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effectiveness of Astaxanthin Supplementation on the Clinical Symptoms and Cardio-metabolic Profile in Women with Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT06642363. IPD Sharing: NO. Countries: 1. Publications: 20.
The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
ClinicalTrials.gov study NCT04689984. IPD Sharing: NO. Countries: 1. Publications: 9.
Curcumin & Astaxanthin for Lowering Triglyceride Readings and Inflammation
ClinicalTrials.gov study NCT07063056. IPD Sharing: NO. Countries: 1. Publications: 4.
The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT03991286. IPD Sharing: NO. Countries: 1. Publications: 1.
Astaxanthin Supplementation in Cyclists
ClinicalTrials.gov study NCT01241877. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Astaxanthin Formulation Bioavailability
ClinicalTrials.gov study NCT02397811. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Impact of Astaxanthin on Cognition in Recreationally Active Females
ClinicalTrials.gov study NCT06460181. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluating Astaxanthin Bioavailability, and a New Technology for Improving it, Using Natural Food Materials Only
ClinicalTrials.gov study NCT04583722. IPD Sharing: NO. Countries: 1. Publications: 0.
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