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50 results for “BBB”
BBB permeability, sleep and qRT-PCR data for: The Drosophila blood-brain barrier regulates sleep via moody GPCR signaling
<p class="MsoNormal"><span>Sleep is vital for most animals, yet its mechanism and function remain unclear. We found that permeability of the BBB–the organ required for maintenance of homeostatic levels of nutrients, ions, and other molecules in the brain–is modulated by sleep deprivation and can cell-autonomously effect sleep changes. We observed increased BBB permeability in </span>known<span> sleep mutants as well as in acutely sleep deprived animals. In addition to molecular tracers, sleep deprivation-induced BBB changes also increased penetration of drugs used in the treatment of brain pathologies. After chronic</span>/<span> genetic or acute sleep deprivation, rebound sleep or administration of the sleeping aid gaboxadol normalized BBB permeability, showing that sleep deprivation effects on the BBB are reversible. Along with BBB permeability, RNA levels of the BBB master regulator <em>moody</em> are modulated by sleep. Conversely, altering BBB permeability alone through glia-specific modulation of <em>moody, gαo, loco, lachesin</em>, or <em>neuroglian</em> – each a well-studied regulator of BBB function – was sufficient to induce robust sleep phenotypes. These studies demonstrate a tight link between BBB permeability and sleep and indicate a novel role for the BBB in the regulation of sleep. </span></p>
BBB permeability, sleep and qRT-PCR data for: The Drosophila blood-brain barrier regulates sleep via moody GPCR signaling
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Innovative Strategies for Blood-Brain Barrier (BBB) Permeability Modeling: Harnessing the Power of Machine Learning-based q-RASAR Approach
<p>In the current research, we have unveiled an advanced technique termed the quantitative Read-Across Structure-Activity Relationship (q-RASAR) framework to harnesses the power of machine learning (ML) for significantly enhancing the precision of predictions related to blood-brain barrier (BBB) permeability. It is important to emphasize that the central objective of this study is not to introduce another model for predicting BBB permeability. Instead, our focus is on highlighting the improvement in predicting the BBB permeability of organic compounds by introducing the q-RASAR approach. This innovative methodology strives to enhance the precision of evaluating neuropharmacological implications and streamline the drug development process. In this investigation, we developed an ML-based q-RASAR PLS model using a dataset comprising 1012 compounds of diverse classes of heterocyclic and aromatic hydrocarbons, obtained from the freely accessible B3DB database (accessible at <a href="https://github.com/theochem/B3DB">https://github.com/theochem/B3DB</a>) to predict BBB permeability during the lead discovery phase for central nervous system (CNS) drugs. The model's predictive capability underwent validation using two external sets, encompassing a total of 1,130,315 compounds, including synthetic compounds and natural products (NPs) for data gap filling and other two external sets comprising 116 drug-like/drug compounds from FDA and ChEMBL databases to assess the model's reliability. This study aimed to bridge the data gap by employing a predictive model to estimate the impact of brain-plasma concentration ratios on BBB permeability for both synthetic compounds and natural products (NPs). To further enhance predictability, we have developed various other ML-based q-RASAR models. The insights from the developed model highlight the pivotal roles played by hydrophobicity, electronic effects, degree of ionization and steric factors as essential features facilitating the traversal of the blood-brain barrier. This research not only advances our understanding of the molecular determinants influencing the permeability of central nervous system drugs but also establishes a versatile computational platform for the rapid assessment of diverse compounds, facilitating informed decision-making in the realms of drug development and design.</p>
Safety and Efficacy of Transient Opening of the Blood-brain Barrier (BBB) With the SonoCloud-9
ClinicalTrials.gov study NCT03744026. IPD Sharing: NO. Countries: 2. Publications: 2.
Safety of BBB Opening With the SonoCloud
ClinicalTrials.gov study NCT02253212. IPD Sharing: Not stated. Countries: 1. Publications: 2.
RCHOP Chemoimmunotherapy Preceded BY BBB Permeabilization by t-NGR Necrosis Factor
ClinicalTrials.gov study NCT03536039. IPD Sharing: NO. Countries: 1. Publications: 8.
Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-ar
ClinicalTrials.gov study NCT06818331. IPD Sharing: NO. Countries: 1. Publications: 20.
ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
ClinicalTrials.gov study NCT03671889. IPD Sharing: NO. Countries: 1. Publications: 4.
Safety of BBB Disruption Using NaviFUS System in Recurrent Glioblastoma Multiforme (GBM) Patients
ClinicalTrials.gov study NCT03626896. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption
ClinicalTrials.gov study NCT03551249. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption for Treatment of Glioma
ClinicalTrials.gov study NCT03616860. IPD Sharing: NO. Countries: 1. Publications: 2.
Liquid Biopsy Following BBB Disruption Using Barrier Disrupting Fields in Patients Undergoing Spine Surgery
ClinicalTrials.gov study NCT07224451. IPD Sharing: YES. Countries: 1. Publications: 2.
Effect of Deep TMS on the Permeability of the BBB in Patients With Glioblastoma Multiforme: a Pilot Study
ClinicalTrials.gov study NCT02474966. IPD Sharing: Not stated. Countries: 0. Publications: 15.
[18F]MC225 PET to Evaluate Gender Differences in BBB P-gp Function
ClinicalTrials.gov study NCT05618119. IPD Sharing: NO. Countries: 0. Publications: 1.
Meropenem Penetration Across BBB in Patients With CNS Infection and Optimization of Meropenem Treatment
ClinicalTrials.gov study NCT02506686. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Reduced Notch signaling in BBB vascular endothelial cells mediates high fat diet-induced alterations in brain glucose uptake and insulin signaling
GEO Series GSE210620. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA expression profile of adult male and female blood brain barrier (BBB) cells of Drosophila melangaster
GEO Series GSE157122. Drosophila melanogaster. 6 samples. Type: Expression profiling by array.
Drug intervention of radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation
GEO Series GSE280304. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing of blood-brain barrier (BBB) microvessels from mice with orthotopic GBM showing the benefit of triple therapy combining anti-immune checkpoint therapy with dual-anti angiogenic therapy.
GEO Series GSE130324. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing of blood-brain barrier (BBB) microvessels from mice with hematogenous pneumococcal meningtis
GEO Series GSE122952. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.