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Dataset results
144 results for “BCL6”
BCL6 deletion in CD4 T cells reveals Th2 eff mediated immunity in the skin
<p>RNA-Seq datasets related to the study of Mouse Tfh cells.</p> <p>Recent studies propose that Group 2 T follicular helper (Tfh) cells have a higher degree of functional plasticity in addition to their well-defined roles in mediating IL-4-dependent switching of germinal centre B cells to the production of IgG1 and IgE antibodies. In particular Tfh cells have been proposed to be an essential stage in Th2 effector cell development that are able to contribute to innate Type 2 responses. We used CD4-cre targeted deletion of BCL6 to identify the contribution Tfh cells make to tissue Th2 effector responses in models of skin atopic disease and lung immunity to parasites. Ablation of Tfh cells did not impair the development or recruitment of Th2 effector subsets to the skin and did not alter the transcriptional expression profile or functional activities of the resulting tissue resident Th2 effector cells. However, the accumulation of Th2 effector cells in lung Th2 responses was partially affected by BCL6 deficiency. These data indicate that the development of Th2 effector cells does not require a BCL6 dependent step implying Tfh and Th2 effector populations follow separate developmental trajectories and Tfh cells do not contribute to Type 2 responses in the skin . This study reveals important findings that add to the growing literature around the plasticity and functional interconversion of T helper subsets. </p>
High confidence calls (BCL6-R FL and DLBCL)
<p>High confidence calls (BCL6-R FL and DLBCL)</p>
Transcriptional Changes during T cell development following conditional loss of Bcl6
GEO Series GSE152944. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 5]
GEO Series GSE138395. Mus musculus. 23 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
EZH2 and BCL6 cooperate to assemble CBX8-BCOR Polycomb complex to repress bivalent promoters, mediate germinal center formation and promote lymphomagenesis
GEO Series GSE81705. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses
GEO Series GSE128166. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Comparison of copy number variations between wildtype and BCL6 knockout BCR-ABL1-driven acute lymphoblastic leukemia
GEO Series GSE24400. Mus musculus. 6 samples. Type: Genome variation profiling by genome tiling array.
BCL6 enforces human glioblastoma growth and serves as a novel therapeutic target (expression)
GEO Series GSE77053. Homo sapiens. 4 samples. Type: Expression profiling by array.
BCL6 is regulated by the RAS/MAPK/ELK axis and promotes KRAS-driven lung cancers
GEO Series GSE189545. Mus musculus; Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver
GEO Series GSE31578. Mus musculus. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
BCL6 is required for the initiation and maintenance of chronic myeloid leukemia
GEO Series GSE26085. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
EZH2 and BCL6 cooperate to assemble CBX8-BCOR Polycomb complex to repress bivalent promoters, mediate germinal center formation and promote lymphomagenesis [ChIP-seq]
GEO Series GSE81623. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza infection
GEO Series GSE126622. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors
GEO Series GSE121766. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
RNA-seq analysis of the effects of BCL6-inhibiting and BCL6-degrading compounds in lymphoma cell lines
GEO Series GSE94099. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen [TCR-seq]
GEO Series GSE181442. Mus musculus. 19 samples. Type: Other.
Bcl6 and NFkB cistromes mediate opposing reulation of the innate immune response
GEO Series GSE16723. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters
GEO Series GSE29282. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
GEO Series GSE181474. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Ablation of adipocyte BCL6 enhances subcutaneous adiposity and insulin sensitivity
GEO Series GSE113408. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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