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12 results for “Bacterial competition”
Resource competition predicts assembly of in vitro gut bacterial communities
<p>Microbiota dynamics arise from a plethora of interspecies interactions, including resource competition, cross-feeding, and pH modulation. The individual contributions of these mechanisms are challenging to untangle, especially in natural or complex laboratory environments where the landscape of resource competition is unclear. Here, we developed a framework to estimate the extent of multi-species niche overlaps by combining metabolomics data of individual species, growth measurements in pairwise spent media, and mathematical models. When applied to an in vitro model system of human gut commensals in complex media, our framework revealed that a simple model of resource competition described most pairwise interactions. By grouping metabolomic features depleted by the same set of species, we constructed a coarse-grained consumer-resource model that predicted assembly compositions to reasonable accuracy. Moreover, deviations from model predictions enabled us to identify and incorporate into the model additional interactions, including pH-mediated effects and cross-feeding, which improved model performance. In sum, our work provides an experimental and theoretical framework to dissect microbial interactions in complex in vitro environments.</p>
Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system
<div> <div> <div> <div> <div> <p>This dataset accompanies the publication "Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system" (Otto <em>et al., </em>2024). It encompasses the raw data for all graphs, <em>p</em> values, and growth rates associated with the study.</p> </div> </div> </div> </div> </div>
Data from: Seasonal variation in the biocontrol efficiency of bacterial wilt is driven by temperature-mediated changes in bacterial competitive interactions
1. Microbe-based biocontrol applications hold the potential to become an efficient way to control plant pathogen disease outbreaks in the future. However, their efficiency is still very variable, which could be due to their sensitivity to the abiotic environmental conditions. 2. Here we assessed how environmental temperature variation correlates with the Ralstonia pickettii, an endophytic bacterial biocontrol agent, ability to suppress Ralstonia solanacearum pathogen during different tomato crop seasons in China. 3. We found that the pathogen suppression was highest when the seasonal mean temperatures were around 20 °C and rapidly decreased with increasing mean crop season temperatures. Interestingly, low levels of disease incidence did not correlate with low pathogen or high biocontrol agent absolute densities. Instead, the biocontrol to pathogen density ratio was more important predictor of disease incidence levels between different crop season. To understand this mechanistically, we measured the growth and strength of competition between the biocontrol agent and the pathogen over a naturally occurring temperature gradient in vitro. We found that the biocontrol strain grew relatively faster at low, and the pathogen at high temperature ranges, and that similar to field experiments, pathogen suppression peaked at 20° C. 4. Together our results suggest that temperature-mediated changes in the strength of bacterial competition could potentially explain the variable R. solanacearum biocontrol outcomes between different crop seasons in China. 5. Synthesis and applications. Bacterial strains that can retain their functionality regardless of the environmental conditions (i.e. have flat reaction norms), could be good candidate species for developing more consistent biocontrol applications.
Data from: Population-level dynamics in experimental mixed infections: evidence for competitive exclusion among bacterial parasites of Paramecium caudatum
Parasites frequently share their host populations with other parasites. However, little is known about how different parasites respond to competition with diverse competitor species in the within-host and between-host environments. We explored the repeatability of competition by simultaneously exposing microcosm populations of the ciliate Paramecium caudatum to pairs of parasites from the Holospora species complex (H. undulata, H. caryophila and H. obtusa) affected the persistence and prevalence of each compared to single infections, across three host genotypes. Three weeks post-inoculation we identified the presence of each parasite using fluorescence in situ hybridisation (FISH). Competitive exclusion (62/72) was more common than co-existence (10/72) in populations inoculated with 2 parasites. There was a clear pattern of competitive superiority, with H. caryophila persisting in all doubly inoculated populations (with either H. undulata or H. obtusa), and H. undulata tending to exclude H. obtusa. This mirrored infection success in single infections, with H. caryophila having a higher infection prevalence in single inoculations, followed by H. undulata then H. obtusa. The probability of persistence in co-inoculations did not change across the different host genotypes, and prevalence was the same as in single infections. Our results are consistent with superinfection models, which assume the competitive exclusion of parasites upon contact within the same host. Furthermore, such non-random competitive epidemiological dynamics, where one parasites always wins, may be of interest for public health management, especially if the winning parasite is avirulent, as is seemingly the case here.
Data accompanying "Oxidative stress changes interactions between two bacterial species from competitive to facilitative"
<p>Raw data used to generate all figures in the associated manuscript.</p>
Data from: Seasonal variation in the biocontrol efficiency of bacterial wilt is driven by temperature-mediated changes in bacterial competitive interactions
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Data from: Polylysogeny magnifies competitiveness of a bacterial pathogen in vivo
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Data from: Bacterial competition and quorum-sensing signalling shapes the eco-evolutionary outcomes of model in vitro phage therapy
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Data from: Population-level dynamics in experimental mixed infections: evidence for competitive exclusion among bacterial parasites of Paramecium caudatum
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Data from: Carbon resource richness shapes bacterial competitive interactions by alleviating growth-antibiosis trade-off
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Multifactorial competition and resistance in a two-species bacterial system
GEO Series GSE72283. Escherichia coli. 4 samples. Type: Expression profiling by array.
Microbiome remodeling through bacterial competition and host behavior enables rapid adaptation to environmental toxins
GEO Series GSE246966. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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