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1,389 results for “Bladder cancer”
CD45+ cells from human bladder cancer specimens
<h3><span>Background</span></h3> <p><span>NK cells are important innate defenders against tumours and have unique abilities to recognize and eliminate cancer cells. Responses to targeted antibody therapeutics are typically limited in bladder tumours, and the functional and immunosuppressive phenotypes of NK cells in this disease are largely unknown. </span></p> <h3><span>Methods</span></h3> <p><span>Single cell RNA sequencing (scRNAseq) and high-dimensional flow cytometry were used to investigate the phenotype of intratumoural NK cells compared to circulating in patients with bladder cancer.</span></p> <h3><span>Findings</span></h3> <p><span>NK cells residing within bladder tumours had reduced expression of Fc</span><span>γ</span><span>RIIIa/CD16, the critical receptor for NK-cell-mediated ADCC, on both a transcriptional and protein level. Transcriptional signatures of </span><span>TGF-β-signalling, a pleiotropic cytokine with known immunosuppressive effects on NK cells, were upregulated in tumour NK cells compared to the blood. In concert, a high TGF-β signature expression also correlated with worse survival and CD16 downregulation. We directly validated this TGF-β mediated CD16 downregulation on NK cells in vitro and it was accompanied by a transition to ILC1-like NK cells. We also uncovered a high proportion of tumour infiltrating-Treg cells, and in vivo studies show that NK cells delivered in the presence of accompanying immune cells have a greater reduction of CD16 compared to NK cells delivered alone. </span></p> <h3><span>Interpretation</span></h3> <p><span>Thus, this study highlights how TGF-β rich bladder cancers could inhibit NK cell ADCC by downregulating CD16, whereby Treg cells could be a major limiter of NK cell effector functions in these tumours.</span></p>
Lund Bladder Cancer Group - Lund Taxonomy 2023 Classifier - Training Data
<p>Raw and processed training data used for the Lund Taxonomy 2023 gene expression classifier for urothelial carcinoma.</p><p>The dataset contains the raw .CEL files for 3 Affymetrix Gene 1.0 ST cohorts: Lund2017 (n=307, GSE83586), Lund2020 (n=173, GSE128959), Lund2022 (n=310, 117 from GSE169455, 37 from GSE222073, and 156 previously unpublished samples). Code examples for RMA and SCAN.UPC normalization for Affymetrix Gene, Exon, and HTA2 arrays used in the study is included. Hybridization batch information is available for each array cohort.</p><p>The dataset contains Kallisto and Salmon transcript quantification files for 265 RNA-sequenced tumors and the tx2gene file+code for transcript to gene summarization using txImport</p><p> </p>
ATAC-seq analysis for intravesical BCG in bladder cancer
<p>BCG vaccination can boost innate immune responses via trained immunity (TI), resulting in an increased resistance to respiratory viral infections. Assay for transposase accessible chromatin (ATAC), including tagmentation, library preparation and sequencing were performed by Genewiz (Azenta Life Sciences, MA, USA) on PBMCs from two BCG-treated NMIBC patients at baseline and during BCG (mid) as well as from three healthy donors. This dataset include the pipeline for preprocessing of raw data including mapping to the hg38 reference genome using bowtie2 and peak calling by MACS2. Differentially accessible regions in proximity to annotated genes between the two time points (during BCG versus baseline) were identified using the R packages csaw and edgeR and resulting data files are provided.</p> <p> </p> <p> </p> <p> </p> <p> </p>
18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy
ClinicalTrials.gov study NCT04018053. IPD Sharing: YES. Countries: 1. Publications: 1.
CD45+ cells from human bladder cancer specimens
Open the record for dataset details and reuse information.
Acidic Microenvironment Enhances Cisplatin Resistance in Bladder Cancer via Bcl-2 and XIAP
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The role of TAp63g and p53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cell
<p>Raw data set for the manuscript submitted to e-Life (10-06-2021-RA-eLife-71184 ) for peer-review. </p>
Data deposition of the article 'Multi-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence'
<p>Data deposition of the article 'Multi-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence'</p>
Atezolizumab in Treating Patients With Recurrent BCG-Unresponsive Non-muscle Invasive Bladder Cancer
ClinicalTrials.gov study NCT02844816. IPD Sharing: UNDECIDED. Countries: 2. Publications: 1.
Neoadjuvant Atezolizumab in Localized Bladder Cancer
ClinicalTrials.gov study NCT02451423. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study of Nivolumab in Participants With Metastatic or Unresectable Bladder Cancer
ClinicalTrials.gov study NCT02387996. IPD Sharing: Not stated. Countries: 11. Publications: 1.
An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer
ClinicalTrials.gov study NCT02632409. IPD Sharing: Not stated. Countries: 30. Publications: 6.
EffectiveNess of a Multimodal preHAbilitation Program in patieNts With Bladder canCEr Undergoing Cystectomy
ClinicalTrials.gov study NCT05480735. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Combination Therapy With NC-6004 and Gemcitabine in Advanced Solid Tumors or Non-Small Cell Lung, Biliary and Bladder Cancer
ClinicalTrials.gov study NCT02240238. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer
ClinicalTrials.gov study NCT00118040. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 3 Study of UGN-102 for Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer
ClinicalTrials.gov study NCT04688931. IPD Sharing: Not stated. Countries: 10. Publications: 1.
A Phase II Study of AZD4877 (a Novel Anti-mitotic Agent) in Advanced Bladder Cancer
ClinicalTrials.gov study NCT00661609. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Combination Chemotherapy and Radiation Therapy With/Without Surgery In Patients With Stage II/III Bladder Cancer
ClinicalTrials.gov study NCT00055601. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Randomized, Comparative Study of Hexvix Fluorescence Cystoscopy and Standard Cystoscopy in Patients With Non-invasive Bladder Cancer
ClinicalTrials.gov study NCT00412971. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)
ClinicalTrials.gov study NCT02603432. IPD Sharing: YES. Countries: 29. Publications: 10.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.