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315 results for “Brown Adipose Tissue”
Adipose tissue plasticity in pheochromocytoma patients reveals a key role of the splicing machinery in human adipose browning
<p>RNA-sequencing counts data from omental adipose tissue from control individuals (C1-3) and patients with pheochromocytoma (P1-4) for whole genes (genes-counts.tsv) and individual isoforms (isoform-counts.tsv). Additional details regarding recruited individuals are available in the associated manuscript.</p> <p>Tissue fragments (~150 mg) of adipose biopsies from controls and pheochromocytoma patients were homogenized using a metal bead-based mechanical procedure in a TissueLyser® (QIAGEN, Düsseldorf, Germany). Total RNA was isolated from tissue homogenates using a NucleoSpin® RNA kit (Macherey-Nagel, Dueren, Germany) following the manufacturer’s protocol. mRNA was purified from 2 μg of total RNA using oligo-dT beads; it was then fragmented, retrotranscribed with random primers, and subjected to second-strand synthesis to create double-stranded cDNA fragments. Adaptor ligation, purification of 200-base pair cDNA fragments, amplification of the purified fragments, and library preparation were performed as previously reported by our laboratory. Before sequencing, the RNA integrity number (RIN) of each sample was determined using an Agilent Bioanalyzer 2100; samples with RIN ≥ 7.5 were used for RNA-sequencing. The cDNA library quality and quantity were further analyzed as previously described. Libraries yielding satisfactory results were sequenced on an Illumina HiSeq 2000 sequencer (DNAvision, Charleroi, Belgium). The average reads per sample was 45 million; this level of coverage was previously shown to provide sufficient sequencing depth for gene expression quantification and transcript detection. Quality control of reads was performed using FastQC (version 0.11.8; bioinformatics.babraham.ac.uk/projects/fastqc). Gene expression was quantified using Salmon version 1.1.0 with the additional parameters “– seqBias – gcBias – validateMappings”. GENCODE version 31 (GRCh38.p12) was used as the reference genome and indexed using default parameters; this resulted in 175,775 transcripts corresponding to 35,183 genes.</p>
Brown adipose tissue PET-MR after fructose and glucose intervention
<p>Includes the data and MATLAB functions used to produce the manuscript: "High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake in young men independently of changes in thermogenesis and the gut microbiome"</p>
Effects of b3-Adrenergic Receptor Agonists on Brown Adipose Tissue
ClinicalTrials.gov study NCT01783470. IPD Sharing: NO. Countries: 1. Publications: 1.
Investigating Brown Adipose Tissue Activation in Humans
ClinicalTrials.gov study NCT01935791. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice
Open the record for dataset details and reuse information.
Magnetic resonance imaging reveals human brown adipose tissue is rapidly activated in response to cold
<p class="MsoNoSpacing"><b>Context.</b> In rodents, cold exposure induces the activation of brown adipose tissue (BAT) and the induction of intracellular triacylglycerol (TAG) lipolysis. However, in humans, the kinetics of supraclavicular (SCV) BAT activation and the potential importance of TAG stores remain poorly defined.</p> <p class="MsoNoSpacing"><b>Objective.</b> To determine the time course of BAT activation and changes in intracellular TAG using magnetic resonance imaging (MRI) assessment of the SCV (i.e. BAT depot) and fat in the posterior neck region (i.e. non BAT).</p> <p class="MsoNoSpacing"><b>Design.</b> Cross-sectional.</p> <p class="MsoNoSpacing"><b>Setting.</b> Clinical research centre.</p> <p class="MsoNoSpacing"><b>Patients or Other Participants.</b> Twelve healthy male volunteers ages 18-29 years [BMI=24.7±2.8kg/m<sup>2</sup> and body fat percentage = 25.0±7.4% (both mean±SD)].</p> <p class="MsoNoSpacing"><b>Intervention(s).</b> Standardized whole-body cold exposure (180 minutes at 18<span>°</span>C) and immediate re-warming (30 minutes at 32°C).</p> <p class="MsoNoSpacing"><b>Main Outcome Measure(s).</b> Proton density fat fraction (PDFF) and T2* of the SCV and posterior neck fat pads. Acquisitions occurred at 5-15 minute intervals during cooling and subsequent warming.</p> <p class="MsoNoSpacing"><b>Results.</b> SCV PDFF declined significantly after only 10 minutes of cold exposure [-1.6% (standard error (SE) 0.44%), <i>p</i>=0.007) and continued to decline until 35 minutes after which time it remained stable until 180 minutes. A similar time course was also observed for SCV T2*. In the posterior neck fat (non-BAT) there were no cold-induced changes in PDFF or T2*. Re-warming did not result in a change in SCV PDFF or T2*.</p> <p class="MsoNoSpacing"><b>Conclusions.</b> The rapid cold-induced decline in SCV PDFF suggests that in humans, BAT is activated quickly in response to cold and that TAG is a primary substrate.</p>
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice
<p>We FACS-sorted Osr1-expressing cells (Osr1 GCE/+) from 14 E9.5 and 6 E11.5 mouse embryos and analyzed their gene expression profiles using single-cell RNA sequencing. The data was processed and integrated using Seurat v3. The sample and annotation informations can be accessed via the "<strong>time</strong>" and "<strong>annotations</strong>" columns respectively.</p>
L-arginine and Brown Adipose Tissue
ClinicalTrials.gov study NCT02291458. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Incidence,Factors,and Importance of Brown Adipose Tissue in Chinese Adults
ClinicalTrials.gov study NCT01387438. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Brown Adipose Tissue in Triglyceride Clearance in People
ClinicalTrials.gov study NCT02786251. IPD Sharing: NO. Countries: 1. Publications: 1.
Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans
ClinicalTrials.gov study NCT03269747. IPD Sharing: Not stated. Countries: 1. Publications: 2.
CB1 Receptors in Human Brown Adipose Tissue
ClinicalTrials.gov study NCT02941172. IPD Sharing: NO. Countries: 1. Publications: 1.
The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)
ClinicalTrials.gov study NCT06440122. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Activation of Brown Adipose Tissue Metabolism Using Mirabegron
ClinicalTrials.gov study NCT04823442. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Exenatide and Brown Adipose Tissue
ClinicalTrials.gov study NCT03002675. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Brown Adipose Tissue Pilot
ClinicalTrials.gov study NCT03793127. IPD Sharing: NO. Countries: 1. Publications: 19.
Activating Brown Adipose Tissue Through Exercise
ClinicalTrials.gov study NCT02365129. IPD Sharing: Not stated. Countries: 1. Publications: 18.
The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
ClinicalTrials.gov study NCT02038595. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mirabegron and Brown Adipose Tissue
ClinicalTrials.gov study NCT03012113. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Brown Adipose Tissue Activity in Gilbert's Syndrome
ClinicalTrials.gov study NCT06336369. IPD Sharing: UNDECIDED. Countries: 1. Publications: 18.
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