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214
datasets available to search
ShareScore release 0.9.0
Dataset results
214 results for “CRISPRi”
CRISPRi-based circuits to control gene expression in plants
<p>The plasmid data supporting the publication: CRISPRi-based circuits to control gene expression in plants</p>
Intact protein barcoding enables one-shot identification of CRISPRi strains and their metabolic state
<p>Raw data of "Intact protein barcoding enables one-shot identification of CRISPRi strains and their metabolic state". Agilent .d files were converted to mzml files with MSconvert. The control strain is labelled H2, the CRISPRi strains are indicated by target gene names. The numbers indicate replicate 1,2 and 3.</p> <p> </p>
CRISPRi with barcoded expression reporters dissects regulatory networks in human cells
<p>Genome-wide CRISPR screens have emerged as powerful tools for uncovering the genetic underpinnings of diverse biological processes. Incisive screens often depend on directly measuring molecular phenotypes, such as regulated gene expression changes, provoked by CRISPR-mediated genetic perturbations. Here, we provide quantitative measurements of transcriptional responses in human cells across genome-scale perturbation libraries by coupling CRISPR interference (CRISPRi) with barcoded expression reporter sequencing (CiBER-seq). To enable CiBER-seq in mammalian cells, we optimize the integration of highly complex, barcoded sgRNA libraries into a defined genomic context. CiBER-seq profiling of a nuclear factor kappa B (NF-κB) reporter delineates the canonical signaling cascade linking the transmembrane TNF-alpha receptor to inflammatory gene activation and highlights cell-type-specific factors in this response. Importantly, CiBER-seq relies solely on bulk RNA sequencing to capture the regulatory circuit driving this rapid transcriptional response. Our work demonstrates the accuracy of CiBER-seq and its potential for dissecting genetic networks in mammalian cells with superior time resolution.</p>
Metabolomics dataset relating to the pubblication: "Combining CRISPRi and metabolomics for functional annotation of compound libraries"
<p>Metabolomics dataset relating to the pubblication: "Combining CRISPRi and metabolomics for functional annotation of compound libraries"</p>
Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase
<p>This dataset contains the raw read counts from the CRISPRi-Seq experiments.</p>
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence (CRISPRi screen)
GEO Series GSE232856. Homo sapiens. 4 samples. Type: Other.
CRISPRi RNA-seq from K562 (ENCSR263IOO)
GEO Series GSE127104. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions
GEO Series GSE145530. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation (CRISPRi screen) [786-O]
GEO Series GSE270847. Homo sapiens. 4 samples. Type: Other.
Bioinformatics and single-cell CRISPRi-based screen reveals effector genes and implicates multi-tissue etiology for BMD [bulk RNA-seq]
GEO Series GSE261282. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells
GEO Series GSE85011. Homo sapiens. 112 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer [CRISPRi RNA-seq]
GEO Series GSE195675. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR591QYK)
GEO Series GSE127130. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR713AEC)
GEO Series GSE127141. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR819PCU)
GEO Series GSE127159. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR620DOP)
GEO Series GSE127133. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR376CFR)
GEO Series GSE127115. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR171KMM)
GEO Series GSE127093. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR073QLQ)
GEO Series GSE127078. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi RNA-seq from K562 (ENCSR016WFQ)
GEO Series GSE127063. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.