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146 results for “Cardiogenic shock”
SHOCK Trial - Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock
<p>The leading cause of death in patients hospitalized for acute myocardial infarction is cardiogenic shock. We conducted a randomized trial to evaluate early revascularization in patients with cardiogenic shock. In patients with cardiogenic shock, emergency revascularization did not significantly reduce overall mortality at 30 days. However, after six months there was a significant survival benefit. Our conclusion was that early revascularization should be strongly considered for patients with acute myocardial infarction complicated by cardiogenic shock. We are making original data that was collected for this trial available here for further analysis.</p>
Raw Data for the article: Atrial Septostomy for Left Ventricular Unloading During Extracorporeal Membrane Oxygenation for Cardiogenic Shock: Animal Model
<p><strong>Objectives: </strong>The aim of this study was to quantify and understand the unloading effect of percutaneous balloon atrial septostomy (BAS) in acute cardiogenic shock (CS) treated with venoarterial (VA) extracorporeal membranous oxygenation (ECMO).</p> <p><strong>Background: </strong>In CS treated with VA ECMO, increased left ventricular (LV) afterload is observed that commonly interferes with myocardial recovery or even promotes further LV deterioration. Several techniques for LV unloading exist, but the optimal strategy and the actual extent of such procedures have not been fully disclosed.</p> <p><strong>Methods: </strong>In a porcine model (n = 11; weight 56 kg [53-58 kg]), CS was induced by coronary artery balloon occlusion (57 minutes [53-64 minutes]). Then, a step-up VA ECMO protocol (40-80 mL/kg/min) was run before and after percutaneous BAS was performed. LV pressure-volume loops and multiple hemoglobin saturation data were evaluated. The Wilcoxon rank sum test was used to assess individual variable differences.</p> <p><strong>Results: </strong>Immediately after BAS while on VA ECMO support, LV work decreased significantly: pressure-volume area, end-diastolic pressure, and stroke volume to ∼78% and end-systolic pressure to ∼86%, while superior vena cava and tissue oximetry did not change. During elevating VA ECMO support (40-80 mL/kg/min) with BAS vs without BAS, we observed 1) significantly less mechanical work increase (122% vs 172%); 2) no end-diastolic volume increase (100% vs 111%); and 3) a considerable increase in end-systolic pressure (134% vs 144%).</p> <p><strong>Conclusions: </strong>In acute CS supported by VA ECMO, atrial septostomy is an effective LV unloading tool. LV pressure is a key component of LV work load, so whenever LV work reduction is a priority, arterial pressure should carefully be titrated low while maintaining organ perfusion.</p>
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
ClinicalTrials.gov study NCT02633358. IPD Sharing: NO. Countries: 1. Publications: 8.
Cardiogenic Shock Intravascular Cooling Trial
ClinicalTrials.gov study NCT03141255. IPD Sharing: NO. Countries: 1. Publications: 0.
National Cardiogenic Shock Initiative
ClinicalTrials.gov study NCT03677180. IPD Sharing: NO. Countries: 1. Publications: 13.
Impella CP With VA ECMO for Cardiogenic Shock
ClinicalTrials.gov study NCT03431467. IPD Sharing: NO. Countries: 1. Publications: 0.
Extracorporeal Life Support in Cardiogenic Shock
ClinicalTrials.gov study NCT03637205. IPD Sharing: NO. Countries: 2. Publications: 3.
Clinical Outcomes and Efficacy of Left Ventricular Assist Device for Korean Patients With Cardiogenic Shock
ClinicalTrials.gov study NCT02985008. IPD Sharing: UNDECIDED. Countries: 1. Publications: 23.
Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
ClinicalTrials.gov study NCT00604331. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock
ClinicalTrials.gov study NCT03968926. IPD Sharing: NO. Countries: 1. Publications: 2.
The Safety and Efficacy of Istaroxime for Pre-Cardiogenic Shock
ClinicalTrials.gov study NCT04325035. IPD Sharing: NO. Countries: 4. Publications: 2.
Study Comparing the Efficacy and Tolerability of Epinephrine and Norepinephrine in Cardiogenic Shock
ClinicalTrials.gov study NCT01367743. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluation of Oxiris Membrane as a Treatment for Ischemia-reperfusion Syndrome in Cardiogenic Shock Treated With Extracorporeal Life Support (ECMO/ECLS): A Randomized Pilot Study ECMORIX
ClinicalTrials.gov study NCT04886180. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cardiogenic Shock Registry Mannheim
ClinicalTrials.gov study NCT05575856. IPD Sharing: NO. Countries: 1. Publications: 5.
The Role of Swan-Ganz Catheter in Hemodynamic Resuscitation for Patients With Cardiogenic Shock
ClinicalTrials.gov study NCT07062744. IPD Sharing: NO. Countries: 1. Publications: 18.
Efficacy Study of LV Assist Device to Treat Patients With Cardiogenic Shock (ISAR-SHOCK)
ClinicalTrials.gov study NCT00417378. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.
ClinicalTrials.gov study NCT03773822. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Left Ventricular Unloading to Improve Outcome in Cardiogenic Shock Patients on VA-ECMO
ClinicalTrials.gov study NCT05577195. IPD Sharing: NO. Countries: 1. Publications: 1.
Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock
ClinicalTrials.gov study NCT01927549. IPD Sharing: Not stated. Countries: 1. Publications: 15.
The Effects of IABP Prior to Revascularization on Mortality of ACS Patients Complicated With Cardiogenic Shock
ClinicalTrials.gov study NCT03635840. IPD Sharing: UNDECIDED. Countries: 1. Publications: 21.
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