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240 results for “Cardiotoxicity”
Figure 1 in Cardiotoxic effects of enrofloxacin on electrophysiological activity, cardiac markers, oxidative stress, and haematological findings in rabbits
Figure 1. Histological examination of rabbit heart in the negative control (A) shows normal morphology. Histological examination of rabbit heart in group 1 (B) and group 2 (C) shows normal morphology except for some minor abnormalities including hyperaemia in some areas (H&E, 400×).
Computationally-informed point of departure evaluation for proarrhythmic cardiotoxicity assessment using 3D engineered cardiac microtissues from human iPSC-derived cardiomyocytes
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PROactive Evaluation of Function to Avoid CardioToxicity
ClinicalTrials.gov study NCT03862131. IPD Sharing: NO. Countries: 1. Publications: 0.
STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
ClinicalTrials.gov study NCT02943590. IPD Sharing: NO. Countries: 2. Publications: 4.
Carvedilol for the Prevention of Anthracycline/Anti-HER2 Therapy Associated Cardiotoxicity Among Women With HER2-Positive Breast Cancer Using Myocardial Strain Imaging for Early Risk Stratification
ClinicalTrials.gov study NCT02177175. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Protective effects of <em>Melissa officinalis</em> ethanolic extract on doxorubicin-induced cardiotoxicity in a rat model
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Data from: Anthracycline induced cardiotoxicity: prospective cohort study from Pakistan.
Objectives: To identify anthracycline induced acute (within one month) and early onset chronic progressive (within year) cardiotoxicity in children younger than 16 years of age with childhood malignancies at tertiary care center of Pakistan. Design: Prospective Cohort study. Setting: Aga Khan University, Karachi, Pakistan. Participants: 110 children (aged 1 month to 16 years). Intervention: Anthracycline (Doxorubicin and/or Daunorubicin). Outcome measurements: All children who received anthracycline as chemotherapy and three echocardiographic evaluations (baseline, one month and 1 year) between July 2010 and June 2012 were prospectively analyzed for cardiac dysfunction. Statistical analysis including systolic and diastolic functions at baseline, 1 month and 1 year were made by repeated measures analysis of variance (r-ANOVA). Results: Mean age was 74±44 months and 75 (68.2%) were males. Acute lymphoblastic leukemia (ALL) was seen in 70 (64%) patients. Doxorubicin alone was used in 59 (54%) and combination therapy was used in 35(32%). A cumulative dose of anthracycline <300mg/m2 was in 95 (86%). Fifteen (14%) children developed cardiac dysfunction within a month and 28(25%) children within a year. Of these 10/15 (66.6%) and 12/28 (42%) had isolated diastolic dysfunction respectively, while 5/15 (33.3%) and 16/28 (57%) had combined systolic and diastolic dysfunction. Seven (6.4%) patients expired due to severe cardiac dysfunction. 8/59 (13.5%) children receiving doxorubicin showed dysfunction mostly related to higher cumulative dose (p=<0.001). Cardiotoxicity was high where combination of doxorubicin and daunorubicin was used (p=0.004). Conclusion: Anthracycline induced cardiac dysfunction is high. Long term follow-up is essential in children received any dosage of anthracyclines because of its late manifestation.
A targeted metabolomics-based assay using human induced pluripotent stem cell-derived cardiomyocytes identifies structural and functional cardiotoxicity potential
<p>Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to improve safety and the cost and time required to bring new drugs to market. In this study, a metabolic biomarker-based assay was developed that predicts the cardiotoxicity potential of a drug based on changes in the metabolism and viability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). Assay development and testing was conducted in two phases: (1) biomarker identification and (2) targeted assay development. In the first phase, metabolomic data from hiPSC-CM spent media following exposure to 66 drugs was used to identify biomarkers that identified both functional and structural cardiotoxicants. Four metabolites that represent different metabolic pathways (arachidonic acid, lactic acid, 2'-deoxycytidine, and thymidine) were identified as indicators of cardiotoxicity. In phase two, a targeted, exposure-based biomarker assay was developed that measured these metabolites and hiPSC-CM viability across an eight-point concentration curve. Metabolite-specific predictive thresholds for identifying the cardiotoxicity potential of a drug were established and optimized for balanced accuracy or sensitivity. When predictive thresholds were optimized for balanced accuracy, the assay predicted the cardiotoxicity potential of 81 drugs with 86% balanced accuracy, 83% sensitivity, and 90% specificity. Alternatively, optimizing the thresholds for sensitivity yields a balanced accuracy of 85%, 90% sensitivity, and 79% specificity. This new hiPSC-CM-based assay provides a paradigm that can identify structural and functional cardiotoxic drugs that could be used in conjunction with other endpoints to provide a more comprehensive evaluation of a drug's cardiotoxicity potential.</p>
cardiotoxic_chembl
<p>Cardiotoxic and not compounds based on Chembl-filtered dataset</p>
Library of Two Million Unique Small Molecules with Precalculated Fingerprints, Descriptors, and Cardiotoxicity Inhibition Data
<p>This repository comprises a dataset of ~2 million unique compounds saved in an hdf5 small molecule library store, which includes the following fields for each molecule:</p> <ul> <li>InChI key</li> <li>Standardized SMILES string</li> <li>Compound source</li> <li>ChEMBL identifier if the compound exists in this open access database</li> <li>1024-bit Morgan fingerprint</li> <li>2048-bit Morgan fingerprint</li> <li>881-bit PubChem fingerprints</li> <li>854 vector-length of preprocessed and standardized Mordred descriptors</li> <li>and cardiotoxicity inhibition predictions for each of the three cardiac ion channels (hERG, Nav1.5, and Cav1.2) using <a href="https://github.com/issararab/CToxPred2">CtoxPred2</a> along with the model confidence scores.</li> </ul> <p>The repository also includes a Jupyter notebook that serves as an initial guide for querying the small molecule library store. Export both files to the same folder, allocate approximately 40 GB of available memory disk space, unzip the library store, and then launch the notebook to begin querying.</p> <p><strong>Upon usage, please cite this publication:</strong></p> <ul> <li>Issar Arab, Kris Laukens, Wout Bittremieux, <strong>Semisupervised Learning to Boost hERG, Nav1.5, and Cav1.2 Cardiac Ion Channel Toxicity Prediction by Mining a Large Unlabeled Small Molecule Data Set</strong>, <em>Journal of Chemical Information and Modeling</em>, (2024). doi:<a title="DOI URL" href="https://doi.org/10.1021/acs.jcim.4c01102">10.1021/acs.jcim.4c01102</a></li> </ul>
Measurement of TNF‐α, CK-MB, LDH, IL‐1 and IL-6 levels for anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p>Measurement of TNF‐α, CK-MB, LDH, IL‐1 and IL-6 levels for anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</p>
The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p>The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</p>
The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p><a href="https://zenodo.org/deposit/7360384">The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</a></p>
Feasibility of Switching Fluoropyrimidine Due to Cardiotoxicity Study
ClinicalTrials.gov study NCT04260269. IPD Sharing: NO. Countries: 7. Publications: 8.
Early Detection of Cardiotoxicity From Systemic and Radiation Therapy in Breast Cancer Patients
ClinicalTrials.gov study NCT04790266. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TRUST-ACE - Anticancer-treatment Cardiotoxicity Identification by Echocardiography
ClinicalTrials.gov study NCT06310330. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Study to Evaluate The Cardioprotective Effect of Pentoxifylline Against Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients
ClinicalTrials.gov study NCT07137793. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer
ClinicalTrials.gov study NCT05078190. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy
ClinicalTrials.gov study NCT04939883. IPD Sharing: NO. Countries: 1. Publications: 1.
MyoStrain CMR for the Detection of Cardiotoxicity
ClinicalTrials.gov study NCT03543228. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.