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Dataset results
12 results for “Cav1”
Source data for "Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons"
<p><strong>Fig.1A_ChAT.tif</strong></p><p>Confocal image (green channel, anti-ChAT staining) for Fig.1A</p><p> </p><p><strong>Fig.1A_tdTomato.tif </strong></p><p>Confocal image (red channel, tdTomato) for Fig.1A</p><p> </p><p><strong>Fig.1B_ChAT.tif</strong></p><p>Confocal image (green channel, anti-ChAT staining) for Fig.1B</p><p> </p><p><strong>Fig.1B_tdTomato.tif</strong></p><p>Confocal image (red channel, tdTomato) for Fig.1B</p><p> </p><p><strong>Fig.1C_DIC.png</strong></p><p>Differential interference contrast micrograph for Fig.1C left</p><p> </p><p><strong>Fig.1C_Fluo.png</strong></p><p>Epifluorescent illumination micrograph for Fig. 1C right</p><p> </p><p><strong>Fig.1DEH.xlsx</strong></p><p>Numerical data for the charts in Fig. 1D, Fig.1E, Fig.1H</p><p> </p><p><strong>Fig.1F.tif</strong></p><p>MAX projection of z-stack of 2PLSM images (red channel, Alexa 594) used to generate Fig.1F </p><p> </p><p><strong>Fig.1F_inset.tif</strong></p><p>2PLSM image (green channel, Fura-2) for the right inset of Fig.1F</p><p> </p><p><strong>Fig.2A_inset.tif</strong></p><p>Confocal image (green channel, GFP) for the higher magnification inset of Fig.2A</p><p> </p><p><strong>Fig.2A.tif</strong></p><p>Confocal image (green channel, GFP) for Fig.2A</p><p> </p><p><strong>Fig.2B_bottom.tif</strong></p><p>Confocal image (green channel, GFP) for Fig.2B (bottom and overlay panels)</p><p> </p><p><strong>Fig.2B_top.tif</strong></p><p>Confocal image (red channel, td Tomato) for Fig.2B (top and overlay panels)</p><p> </p><p><strong>Fig.2CE.xlsx</strong></p><p>Numerical data for the charts in Fig. 2C, Fig. 2E</p><p> </p><p><strong>Fig.3B.tif</strong></p><p>Confocal image (green channel, MitoGCaMP6) for Fig.3B and overlay in Fig.3D</p><p> </p><p><strong>Fig.3C.tif</strong></p><p>Confocal image (red channel, tdTomato) for Fig.3C and overlay in Fig.3D</p><p> </p><p><strong>Fig.3E.tif</strong></p><p>2PLSM image (green channel, MitoGCaMP6) for Fig.3E</p><p> </p><p><strong>Fig.3GIJ.xlsx</strong></p><p>Numerical data for the charts in Fig. 3G, Fig. 3I, Fig.3J</p><p> </p><p><strong>Fig.4B.tif</strong></p><p>2PLSM image (green channel, MitoGCaMP6) for Fig.4B</p><p> </p><p><strong>Fig.4DFG.xlsx</strong></p><p>Numerical data for the charts in Fig.4D, Fig.4F, Fig.4G</p><p> </p><p><strong>Fig.5A.tif</strong></p><p>Confocal image (green channel, PercevalHR) for Fig.5A and overlay in Fig.5C</p><p> </p><p><strong>Fig.5B.tif</strong></p><p>Confocal image (red channel, tdTomato) for Fig.5B and overlay in Fig.5C</p><p> </p><p><strong>Fig.5D.tif</strong></p><p>2PLSM image (green channel, PercevalHR) for Fig.5D</p><p> </p><p><strong>Fig.5GHJ.xlsx</strong></p><p>Numerical data for the charts in Fig.5G, Fig.5H, Fig.5J</p><p> </p><p><strong>Fig.6BCD.xlsx</strong></p><p>Numerical data for the charts in Fig.6b, Fig.6C, Fig.6D</p><p> </p><p><strong>Fig.7A.tif</strong></p><p>Confocal image (green channel, mito-roGFP) for Fig.7A and overlay in Fig.7C</p><p> </p><p><strong>Fig.7B.tif</strong></p><p>Confocal image (red channel, tdTomato) for Fig.7B and overlay in Fig.7C</p><p> </p><p><strong>Fig.7D.tif</strong></p><p>2PLSM image (green channel, mito-roGFP) for Fig.7D</p><p> </p><p><strong>Fig.7F.xlsx</strong></p><p>Numerical data for the charts in Fig.7F</p>
Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling
<p><span>L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1) channels transduce channel activities into nuclear signals critical to neuritogenesis. Also, standalone peptides encoded by </span><span><span>Ca<sub>V</sub>1</span> DCT (distal carboxyl-terminus) act as nuclear transcription factors reportedly promoting neuritogenesis. Here, by focusing on exemplary </span><span><span>Ca<sub>V</sub>1</span>.3 and cortical neurons under basal conditions, we discover that cytosolic DCT peptides downregulate neurite outgrowth by the interactions with </span><span><span>Ca<sub>V</sub>1</span>'s apo-calmodulin binding motif. Distinct from nuclear DCT, various cytosolic peptides exert a gradient of inhibitory effects on </span><span>Ca<sup>2+</sup></span><span> influx via CaV1 channels and neurite extension and arborization, and also the intermediate events including CREB activation and c-Fos expression. The inhibition efficacies of DCT are quantitatively correlated with its binding affinities. Meanwhile, c</span><span>ytosolic inhibition tends to facilitate neuritogenesis indirectly by favoring </span><span>Ca<sup>2+</sup>-sensitive nuclear retention of DCT. In summary, DCT peptides as a class of </span><span><span>Ca<sub>V</sub>1</span> inhibitors specifically regulate the channel activity-neuritogenesis coupling in a variant-, affinity-, and localization-dependent manner.</span></p>
Dose, Safety, Tolerability and Immunogenicity of a Stabilized Prefusion RSV F Subunit Protein Vaccine, VRC-RSVRGP084-00-VP (DS-Cav1), Alone or With Alum Adjuvant, in Healthy Adults
ClinicalTrials.gov study NCT03049488. IPD Sharing: NO. Countries: 1. Publications: 6.
Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling
Open the record for dataset details and reuse information.
Expression data comparing Hep3B Caveolin-1 (Cav1) knockdown cells with Hep3B non-target control cells
GEO Series GSE75994. Homo sapiens. 2 samples. Type: Expression profiling by array.
SWAP70 Promotes Atherosclerosis via Endothelial CAV1 Nuclear Translocation
GEO Series GSE301062. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Impact of CAV1 target site blocker (CAV1 TSB) on bleomycin-induced lung fibrosis
GEO Series GSE97826. Mus musculus. 16 samples. Type: Expression profiling by array.
Impact of miR-199-5p overexpression and CAV1 silencing on human lung fibroblasts
GEO Series GSE34815. Homo sapiens. 14 samples. Type: Expression profiling by array.
Expression data from cav1-/+apcmin/+ mouse intestinal tissue
GEO Series GSE124838. Mus musculus. 2 samples. Type: Expression profiling by array.
SWAP70 Promotes Atherosclerosis via Endothelial CAV1 Nuclear Translocation [ATAC-seq]
GEO Series GSE301155. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Detection of Cav1 Calcium Channels in Inflammatory Cells of Asthmatic Children
ClinicalTrials.gov study NCT02809560. IPD Sharing: NO. Countries: 0. Publications: 0.
Gene expression profiling of Cav1 knock down in murine hepatic stellate cell
GEO Series GSE229291. Mus musculus. 9 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.