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Dataset results
31 results for “Centrosomes”
A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells
<p>Annotated WES VCF file and phenotype file used in Gene burden analysis of Naaldijk et al., "A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells", 2023. </p><p> </p>
Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells
<p>Kinetochore tracking data associated with "Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells" by Renda, Miles, et al., Current Biology, 2022.</p> <p>Contact Alexey Khodjakov at alexey.khodjakov@health.ny.gov for any questions or processing routines.</p> <p>Each file contains coordinates of centrioles and kinetochores in a single cell. </p> <p>Key to variables:</p> <p>ao -- time point corresponding to anaphase onset</p> <p>cell_id -- comprises three parts: cell type_treatment_number (NaN when only first 15 min of prometaphase were tracked).</p> <p>centrioles -- coordinates of centrioles. Two pages correspond to the two centrosomes, first three columns are X-Y-Z of the mother and the second three columns are X-Y-Z of the daughter centrioles</p> <p>kinetochores -- coordinates of kinetochores. Each page corresponds to a chromosome. X-Y-Z coordinates of sister kinetochores are in columns 1-3 and 4-6.</p> <p>neb -- time point corresponding to nuclear envelope breakdown.</p> <p>total_chrs -- number of chromosomes in the cell</p> <p>tracked -- number of tracks obtained in the cell</p>
Vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation
<p>Cell polarity is important for controlling cell shape, motility, and cell division processes. Vimentin intermediate filaments are important for cell migration and cell polarization in mesenchymal cells and assembly of vimentin and microtubule networks is dynamically coordinated, but the precise details of how vimentin mediates cell polarity remain unclear. Here, we characterize the effects of vimentin on the structure and function of the centrosome and the stability of microtubule filaments in wild-type and vimentin-null mouse embryonic fibroblasts (mEFs). We find that vimentin mediates the structure of the pericentrosomal material, promotes centrosome-mediated microtubule regrowth, and increases the level of stable acetylated microtubules in the cell. Loss of vimentin also impairs centrosome repositioning during cell polarization and migration processes that occur during wound closure. Our results suggest that vimentin modulates centrosome structure and function as well as microtubule network stability, which has important implications for how cells establish proper cell polarization and persistent migration.</p>
Vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation
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Data from: PPARγ promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level
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Evolutionary conservation of centriole rotational asymmetry in the human centrosome
<p><span>Centrioles are formed by microtubule triplets in a nine-fold symmetric arrangement. In flagellated protists and in animal multiciliated cells, accessory structures tethered to specific triplets render the centrioles rotationally asymmetric, a property that is key to cytoskeletal and cellular organization in these contexts. In contrast, centrioles within the centrosome of animal cells display no conspicuous rotational asymmetry. Here, we uncover rotationally asymmetric molecular features in human centrioles. Using ultrastructure expansion microscopy, we show that LRRCC1, the ortholog of a protein originally characterized in flagellate green algae, associates preferentially to two consecutive triplets in the distal lumen of human centrioles. LRRCC1 partially co-localizes and affects the recruitment of another distal component, C2CD3, which also has an asymmetric localization pattern in the centriole lumen. Together, LRRCC1 and C2CD3 delineate a structure reminiscent of a filamentous density observed by electron microscopy in flagellates, termed the 'acorn'. Functionally, the depletion of LRRCC1 in human cells induced defects in centriole structure, ciliary assembly and ciliary signaling, supporting that LRRCC1 cooperates with C2CD3 to organizing the distal region of centrioles. Since a mutation in the <em>LRRCC1</em> gene has been identified in Joubert syndrome patients, this finding is relevant in the context of human ciliopathies. Taken together, our results demonstrate that rotational asymmetry is an ancient property of centrioles that is broadly conserved in human cells. Our work also reveals that asymmetrically localized proteins are key for primary ciliogenesis and ciliary signaling in human cells.</span></p>
Evolutionary conservation of centriole rotational asymmetry in the human centrosome
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Enzyme-mediated proximity labeling reveals the co-translational targeting of DLGAP5 mRNA to the centrosome during mitosis
GEO Series GSE260463. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease [P15]
GEO Series GSE249689. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease [Embryonic]
GEO Series GSE249692. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Extra centrosomes induce PIDD1-mediated inflammation and Immunosurveillance
GEO Series GSE235120. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
CEP120 Promotes Centrosome Amplification And Progression Of Gastric Cancer Via USP54-Mediated Deubiquitination Of PLK4
GEO Series GSE217567. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [RNA-Seq]
GEO Series GSE195515. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [scRNA-Seq]
GEO Series GSE194312. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ZNF131 suppresses centrosome fragmentation in Glioblastoma stem-like cells through regulation of HAUS5
GEO Series GSE95027. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Centrosome clustering in osteoclasts regulated by CCR5-mediated signaling, involved in bone homeostasis
GEO Series GSE226793. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Centrosomal Localization of DNAJ-PKAc Fusion Heightens PLK1 Inhibitor Sensitivity in Fibrolamellar Cancer
GEO Series GSE250059. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
GEO Series GSE129871. Homo sapiens. 120 samples. Type: Expression profiling by high throughput sequencing.
A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease
GEO Series GSE195516. Mus musculus. 44 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Loss of centrosomal gene ALMS1 alters lipid metabolism and the regulation of processes linked to the extracellular matrix.
GEO Series GSE209844. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.