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Dataset results
19 results for “Cholecystokinin”
The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the lateral amygdala via cholecystokinin
<p>Although the neural circuitry underlying fear memory formation is important in fear-related mental disorders, it is incompletely understood. Here, we utilized trace fear conditioning to study the formation of trace fear memory. We identified the entorhinal cortex (EC) as a critical component of sensory signaling to the amygdala. Moreover, we used the loss of function and rescue experiments to demonstrate that release of the neuropeptide cholecystokinin (CCK) from the EC is required for trace fear memory formation. We discovered that CCK-positive neurons extend from the EC to the lateral nuclei of the amygdala (LA), and inhibition of CCK-dependent signaling in the EC prevented long-term potentiation of sensory signals to the LA and formation of trace fear memory. Altogether, we suggest a model where sensory stimuli trigger the release of CCK from EC neurons, which potentiates sensory signals to the LA, ultimately influencing neural plasticity and trace fear memory formation.</p>
The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the lateral amygdala via cholecystokinin
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Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex
<p>Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice. Mice with a knockout of <em>cck</em> gene (CCK<sup>-/-</sup>) or blockade of CCK-B receptor (CCKBR) showed defective motor learning ability; the success rate of retrieving reward remained at the baseline level compared to the wildtype mice with significantly increased success rate. We observed no long-term potentiation (LTP) upon high-frequency stimulation (HFS) in the motor cortex of CCK<sup>-/-</sup> mice, indicating a possible association between motor learning deficiency and neuronal plasticity in the motor cortex. In vivo calcium imaging demonstrated that the deficiency of CCK signalling disrupted the refinement of population neuronal activity in the motor cortex during motor skill training. Anatomical tracing revealed direct projections from CCK-expressing neurons in the rhinal cortex to the motor cortex. Inactivating the CCK neurons in the rhinal cortex using chemogenetic methods significantly suppressed motor learning, and intraperitoneal application of CCK4, a tetrapeptide CCK agonist, rescued the motor learning deficits of CCK<sup>-/-</sup> mice. In summary, our results suggest that CCK, which could be provided from the rhinal cortex, enables neuroplasticity in the motor cortex leading to motor skill learning.</p>
Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex
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Data and code from: Cholecystokinin modulates age-dependent thalamocortical neuroplasticity
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The Effect of Exogenous Glucagon-like Peptide 2 on Cholecystokinin-induced Gallbladder Emptying
ClinicalTrials.gov study NCT04651868. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effect of Metformin and Cholecystokinin-mediated Gallbladder Emptying on GLP-1 Secretion in Type 2 Diabetes
ClinicalTrials.gov study NCT02497313. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gallbladder Functions & Serum Cholecystokinin Levels in Women Diagnosed With Hyperemesis Gravidarum
ClinicalTrials.gov study NCT03950167. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development [CUT&RUN]
GEO Series GSE280947. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cholecystokinin 1 Receptor (Cck1R) Activation Restores Normal mTORC1 signaling and is Protective to Purkinje cells of SCA Mice
GEO Series GSE180969. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development
GEO Series GSE269034. Ctenopharyngodon idella. 1 samples. Type: Expression profiling by high throughput sequencing.
Hypoxia induced cholecystokinin gene expression in 3D engineered muscle.
GEO Series GSE135373. Mus musculus. 4 samples. Type: Expression profiling by array.
Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
GEO Series GSE279485. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
GEO Series GSE287290. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis
ClinicalTrials.gov study NCT00004414. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cholecystokinin for Reducing Binge Eating in People With Bulimia Nervosa
ClinicalTrials.gov study NCT00308776. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development
GEO Series GSE268914. Ctenopharyngodon idella. 1 samples. Type: Expression profiling by high throughput sequencing.
Immunoglobulin-like domain receptor 1 mediates fat-stimulated cholecystokinin secretion.
GEO Series GSE47196. Mus musculus. 6 samples. Type: Expression profiling by array.
Chronic constriction injury in cholecystokinin b receptor (Cckbr)-deficient mice
GEO Series GSE9594. Mus musculus. 32 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.